Venous leg ulcers: a prognostic index to predict time to healing.

Skene, A I; Smith, Jacqueline; Doré, Caroline J; Charlett, André; Lewis, Jayne Elizabeth

doi:10.1136/bmj.305.6862.1119

Cited by 172 publications

(123 citation statements)

References 11 publications

(2 reference statements)

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“…11 With the demographic changes that have occurred in the present day to population of the developed countries, 11 as well as in Brazil, geriatric diseases are expected to be more frequent in the medical routine, and among them leg ulcers.…”

Section: Discussionmentioning

confidence: 99%

Úlcera de perna: um estudo de casos em Juiz de Fora-MG (Brasil) e região

Frade

Cursi

Andrade

et al. 2005

An. Bras. Dermatol.

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BACKGROUND: Leg ulcers are characterized as tissue loss in the lower extremities, generally caused by vascular dysfunction. OBJECTIVES: Verify the clinical and epidemiological profiles of the population sample with leg ulcers treated at the health centers of Juiz de Fora (Brazil). MATERIAL AND METHODS: 124 leg-wound patients were evaluated between January 1999 and August 2001 and submitted to a clinical protocol. RESULTS: The mean age was 64 years, with females in the majority (65.3%). The mean family composition was 3.7 persons, and family income was around US$200.00 (86.8%). Venous insufficiency (90.3%), systemic arterial hypertension (54%), obesity (20.2%) and diabetes mellitus (16.1%) were the most frequent events associated with the ulcers. An association of venous insufficiency and arterial hypertension was frequent in 43.7% of the sample, and significant (p<0.01) to predisposition to the ulcers. These were classified as venous (79%), hypertensive (15.4%), mixed and other (5.6%). The ulcers were generally localized in the distal third of legs (90%) and considered large (>5 cm) in about 90% of the sample, with means of 8.7 cm and 9.6 cm to vertical and horizontal axes, respectively. The ulcers were accompanied mainly by hyperpigmentation (92.7%), lipodermatosclerosis (68.5%) and varicose veins (66.9%), with a mean duration of 94.2 months and 50% of them recurrent. CONCLUSIONS: The data suggested that leg ulcer is an important chronic disease in the elderly and poor population of Juiz de Fora and region. Keywords: Aged; Income; Family income; Leg ulcers/ epidemiology; Varicose veins. Resumo: FUNDAMENTOS: Úlcera de perna (UP) caracteriza-se por perda do tegumento nas extremidades dos membros inferiores causada geral

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Section: Discussionmentioning

confidence: 99%

Úlcera de perna: um estudo de casos em Juiz de Fora-MG (Brasil) e região

Frade

Cursi

Andrade

et al. 2005

An. Bras. Dermatol.

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“…Increased age was associated with slower healing rates in one study, 47 therefore age would be considered as a potential factor influencing healing. Only patients of 18 years and over were entered into the trial.…”

Section: Date Of Birthmentioning

confidence: 99%

“…9,10,47 The majority of patients in this trial (82%; 316/387) had a reference ulcer with an area of ≤ 10 cm 2 . A few ulcers were very large, ranging up to 255 cm 2 (almost 16 by 16 cm square) ( Table 6).…”

Section: Area Of Reference Ulcermentioning

confidence: 99%

“…If a larger number of really large ulcers, say >100 cm 2 , was recruited into one trial arm, then the unadjusted analysis would not take this into account and therefore may be biased against the treatment arm containing the very large ulcers. The following variables were considered as potential covariates (prognostic factors for ulcer healing) for the Cox proportional hazards model: [8][9][10]47,70 G number of episodes of ulceration G duration of current ulcers in months G total area of ulceration at baseline…”

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confidence: 99%

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VenUS I: a randomised controlled trial of two types of bandage for treating venous leg ulcers

Iglesias¹,

Nelson²,

Cullum

et al. 2004

Health Technol Assess

116

105

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“…As summarized in Table 1, several studies have shown no association between any specific bacterial species and healing outcomes. 16,[29][30][31][32][33] Among studies that show associations, there are conflicting conclusions on the relevance of many of the commonly isolated species, such as Staphylococcus aureus and Pseudomonas species, as well as anaerobes ( Table 2). Most studies of S. aureus show no association with healing delay or increased ulcer size.…”

Section: Presence Of Pathogenic Organismsmentioning

confidence: 99%