Venous cryopreservation: Endothelial fibrinolytic activity and histology

Malone, James M.; Moore, Wesley S.; Kischer, C. Ward; Keown, Ken; Conine, R.

doi:10.1016/0022-4804(80)90163-8

Cited by 22 publications

(3 citation statements)

References 7 publications

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“…36 Similar observation have been reported for porcine aortae 39 and iliac arteries 2,40 and for rabbit carotid arteries after exposure to DMSO 41 and EG. 38 As observed with arteries, exposure of human saphenous veins 6 and canine jugular veins tolerate exposure to a cryomedium containing DMSO 37,42,43 and glycerol 43 as demonstrated by preserved fibrinolytic activity, 42 contractile function 6,37 and morphology. 43…”

Section: Cryomediamentioning

confidence: 95%

“…75,76 Fibrinolytic activity has been suggested as a quantitative criterion of venous endothelial integrity. 42,77 However, because the basal production of 6-keto-prostaglandin F 1α , a stable breakdown product of PGI 2 , is significantly higher in cryopreserved than in unfrozen human 78,79 and canine saphenous veins 80,81 and because the action of enzymes is generally well preserved during cryopreservation, 15,22,78,79,82 maintained fibrinolytic activity is not indicative of endothelial integrity and cell viability. 78 Calcium metabolism.…”

Section: Reversibility Of Cryoinjurymentioning

confidence: 99%

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Cryopreservation of vascular tissues

Müller‐Schweinitzer¹

2009

Organogenesis

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Cryopreservation of human blood vessels may become an important tool in bypass surgery and peripheral vascular reconstruction. Ideally cryopreservation of a blood vessel should preserve functional characteristics comparable to those of fresh controls. The key advantage of cryopreservation is the fact that storage at deep subzero temperatures allows storage of structurally intact living vascular tissues for virtually infinite time. Originally developed for long-time storage of isolated cells, the techniques of cryopreservation of tissues are challenged by the fact that these are complex multicellular systems containing diverse types of cells with differing requirements for optimal preservation. Therefore, the post-thaw functional activity of vascular tissues is determined by the type of blood vessel and, in addition, by the cell packing effect. Moreover, evidence from pharmacological studies suggests that cryopreservation induces tissue specific changes in transmembrane signaling and the mechanisms coupling intracellular calcium release, sensitivity and calcium entry into the smooth muscle cells.

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Section: Cryomediamentioning

confidence: 95%

Section: Reversibility Of Cryoinjurymentioning

confidence: 99%

Cryopreservation of vascular tissues

Müller‐Schweinitzer¹

2009

Organogenesis

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show abstract

“…known, 6,9 particularly in distal revascularization when the autogenous vein is unsuitable. 10,11 Few good clinical results with cryopreserved arterial homografts implanted in infected sites 12,13 have been reported.…”

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confidence: 99%