Venous allografts for critical limb ischemia

Damme, Hendrik Van; Creemers, Etienne; Limet, Raymond

doi:10.1007/978-3-642-72515-9_22

Cited by 4 publications

(6 citation statements)

References 20 publications

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“…Currently, only six studies have reported the use of venous allografts preserved at 4 C for infrainguinal bypasses [11][12][13][14][15][16] (Table IX). Our experience is the first evaluating cold-stored venous allograft only supplied by BioProtec and reporting outcomes according to the OPGs of the SVS for CLI.…”

Section: Discussionmentioning

confidence: 97%

“…Cold-stored venous allografts can be an alternative to cryopreservation. [11][12][13][14][15][16] In our institution, since 2002, we have used cold-stored venous allografts obtained from ablation of varicose GSVs. The aim of this study was to assess our long-term results of below-knee revascularizations using a cold-stored venous allograft in patients with CLI.…”

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confidence: 99%

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Outcomes of cold-stored venous allograft for below-knee bypasses in patients with critical limb ischemia

Ziza

Canaud

Gandet

et al. 2015

Journal of Vascular Surgery

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Cold-stored venous allografts may be used for performing infragenicular revascularization for CLI with acceptable safety and efficacy results despite poor long-term patency. Their level of performance remains inferior to autologous vein sources but seems comparable to alternative allografts or prosthetic conduit. Their availability is a major advantage compared with other biologic alternative sources.

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Outcomes of cold-stored venous allograft for below-knee bypasses in patients with critical limb ischemia

Ziza

Canaud

Gandet

et al. 2015

Journal of Vascular Surgery

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“…Allogeneic venous grafts for bypass surgery may provide the only alternative to limb amputation in patients with peripheral arterial occlusive vascular disease lacking available autologous veins (1)(2)(3)(4)(5).…”

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confidence: 99%

Donor‐specific sensitization by cadaveric venous allografts used for arterial reconstruction in peripheral arterial occlusive vascular disease

et al. 2004

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The use of allogeneic venous grafts from postmortal organ donors allows for the reconstruction of critically affected arteries in patients with peripheral occlusive vascular disease. We were interested to determine the prevalence and specificity of anti-HLA antibodies in patients after allogeneic vein transplantation. Anti-HLA class I and II alloantibodies were analyzed by flowcytometric analysis using color-coded microbeads coated with HLA antigens including recombinant single antigens. Nine out of 10 patients involving 12 venous allografts were positive for anti-HLA alloantibodies. All antibody-positive patients carried both anti-HLA class I and II alloantibodies. Anti-donor HLA specificity of the anti-HLA alloantibodies was seen in seven out of nine patients for anti-class I antibodies and in eight out of nine patients for anti-HLA class II antibodies. A high rate of donor-specific allosensitization was seen after allogeneic venous transplantation. In conclusion, allosensitization not only includes a humoral response against the constitutively expressed class I antigens but also extends to class II antigens.

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“…wird immer wieder in verzweifelten Fällen durchgeführt [13]. Probleme ergaben sich in der Vergangenheit aus der stenosierenden und aneurysmatischen Degeneration der Transplantate, so dass die Frustrationsschwelle immer niedrig blieb [18,22,23]. Neuartig sind in dieser Serie die Berück-sichtigung immunologischer Gesichtspunkte und die additive Einführung einer immunsuppressiven Therapie.…”

Section: Indikationunclassified

“…Demnach wäre eine 3-monatige Kumarintherapie ausreichend,um die Reendothelialisierung der Spendervene schützend zu überbrücken [8]. Van Damme hat 1993 bei autologen Rekonstruktionen sogar primär Thrombozytenaggregationshemmer eingesetzt und dennoch eine Offenheitsrate seiner poplitealen bzw.kruralen Bypässe von 91,7% nach 11 Monaten erreicht [23].…”

Section: Antikoagulationunclassified

Die homologe Venentransplantation zur kruropedalen arteriellen Rekonstruktion

et al. 2004

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Allogenic venous transplantation represents an alternative procedure for preventing leg amputation. This study reviewed the question of whether immunologic monitoring and immunosuppressive therapy provide results close to those of autologous reconstructions. Twenty-eight patients received 31 homologous venous transplants. The average age in this group of 15 women and 13 men was 64.5 years. Limbs in danger of amputation could be kept longer in two thirds of them. These promising results show the superiority of this method over the use of alloplastic material in regions with cruropedal vessels. Therefore, it can be recommended in acute leg ischemia with lack of autologous vascularity. Improving guidelines for indication will be an interesting research field, and more contributions are needed.

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Venous allografts for critical limb ischemia

Cited by 4 publications

References 20 publications

Outcomes of cold-stored venous allograft for below-knee bypasses in patients with critical limb ischemia

Outcomes of cold-stored venous allograft for below-knee bypasses in patients with critical limb ischemia

Donor‐specific sensitization by cadaveric venous allografts used for arterial reconstruction in peripheral arterial occlusive vascular disease

Die homologe Venentransplantation zur kruropedalen arteriellen Rekonstruktion

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