Venous Compression for Prevention of Postthrombotic Syndrome: A Meta-analysis

Graduated compression stockings

“…33,34 A meta-analysis of five RCTs showed that severe postthrombotic syndrome occurred in 5% of patients given graduated compression stockings and 12% of patients with no compression (relative risk 0.38, 95% CI 0.22 to 0.68). 35 Postthrombotic syndrome of any severity occurred in 26% with stockings and 46% without stockings (relative risk 0.54, 95% CI 0.44 to 0.67). 35 In the UK, NICE recommends that patients with proximal deep vein thrombosis wear belowknee graduated compression stockings with an ankle pressure greater than 23 mm Hg for at least two years beginning a week after diagnosis or when swelling is reduced sufficiently, and if there is no contraindication.…”

“…35 Postthrombotic syndrome of any severity occurred in 26% with stockings and 46% without stockings (relative risk 0.54, 95% CI 0.44 to 0.67). 35 In the UK, NICE recommends that patients with proximal deep vein thrombosis wear belowknee graduated compression stockings with an ankle pressure greater than 23 mm Hg for at least two years beginning a week after diagnosis or when swelling is reduced sufficiently, and if there is no contraindication. 36 The recommendation was based on evidence from two RCTs.…”

Venous compression syndromes: clinical features, imaging findings and management

“…A wide range of signs and symptoms may be seen, including pain, swelling, venous thrombosis, varicosities and haematuria [1,2]. External venous compression incidentally demonstrated by imaging may not be of clinical significance on its own; therefore, imaging should be used for confirmation of the cause of the symptoms.…”

“…Despite its relative infrequency, venous compression is most commonly seen in otherwise healthy and young individuals and may cause significant haemodynamic alterations that may lead to clinical symptoms and significant associated morbidity. Venous compression usually becomes clinically significant when there is a change in the flow direction or increased venous pressure, which lead to the formation of venous collaterals, varicosities and/or chronic venous insufficiency [2]. Repetitive endothelial injury at the site of extrinsic compression predisposes to acute or chronic venous thrombosis, which in turn may aggravate venous hypertension downstream [2].…”

The long-term course of post-thrombotic syndrome after distal deep vein thrombosis and popliteal vein thrombosis

“…Анализ возможного влияния неадекватного компрессионного лечения показал, что риск разви тия ХВН оказался практически одинаков у тех, кто использовал и не использовал компрессионные из делия в соответствии с современными клинически ми рекомендациями. Этот факт вступает в противо речие не только с данными литературы [3,12,13], согласно которым частота развития тяжелой ПТБ снижается на 50%, но и с данными нашей клиники [14]. С другой стороны, эти работы посвящены оценке ситуации в целом в группе больных с веноз ным тромбозом, включая и проксимальный, а ис следование, проведенное нами ранее, было цели ком посвящено именно этой, наиболее тяжелой, категории пациентов.…”