Background:
Cancer is one of the main death causes worldwide. Besides, current therapies and treatments to
counter cancer, it is needed new alternatives to diminish the cell proliferation of oncogenic processes.
Methods:
One of the most promissory therapy includes the use of blue scorpion venom as a specific cytotoxic agent to kill
tumoral cells including Glioblastoma multiforme. We show evidence of the cytotoxic effect of blue scorpion venom in a cellular model of Glioblastoma multiforme.
Results:
Our results demonstrate that 50 µg/ml of scorpion venom is capable to diminish the viability of Glioblastoma populations.
Conclusion:
It is possible that the action mechanism could be associated with a loss of membrane integrity. Additionally,
some metalloproteinases as MMP2 and MMP9 may also participate in the potential action mechanism.