Venlafaxine-loaded sustained-release poly(hydroxyethyl methacrylate-co-itaconic acid) hydrogel composites: their synthesis and in vitro/in vivo attributes

Ali, Liaqat; Ahmad, Mahmood; Aamir, Muhammad Naeem; Minhas, Muhammad Usman; Rasul, Akhtar; Yousuf, Muhammad; Hussain, Hina; Khan, Jawad Ahmad; Sohail, Muhammad

doi:10.1007/s13726-019-00697-4

Cited by 10 publications

(7 citation statements)

References 24 publications

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“…46 Due to the presence of chemical or physical cross-links, they are able to swell and retain large amounts of water, and preserving their structural and dimensional constrained integrity. 47 Hydrogels are biocompatible and biodegradable materials and have been used in cell therapy, drug delivery, biosensing, tissue engineering and wound healing [226][227][228][229] (Table 8).…”

Section: Smart Hydrogelsmentioning

confidence: 99%

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

Bai¹,

Han²,

Dong³

et al. 2020

IJN

147

114

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Diabetic wound shows delayed and incomplete healing processes, which in turn exposes patients to an environment with a high risk of infection. This article has summarized current developments of nanoparticles/hydrogels and nanotechnology used for promoting the wound healing process in either diabetic animal models or patients with diabetes mellitus. These nanoparticles/hydrogels promote diabetic wound healing by loading bioactive molecules (such as growth factors, genes, proteins/peptides, stem cells/exosomes, etc.) and nonbioactive substances (metal ions, oxygen, nitric oxide, etc.). Among them, smart hydrogels (a very promising method for loading many types of bioactive components) are currently favored by researchers. In addition, nanoparticles/hydrogels can be combined with some technology (including PTT, LBL self-assembly technique and 3D-printing technology) to treat diabetic wound repair. By reviewing the recent literatures, we also proposed new strategies for improving multifunctional treatment of diabetic wounds in the future.

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Section: Smart Hydrogelsmentioning

confidence: 99%

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

Bai¹,

Han²,

Dong³

et al. 2020

IJN

147

114

View full text Add to dashboard Cite

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“…Biopolymers based hydrogels are biodegradable and biocompatible materials having potential in drug delivery applications and already reported in tissue engineering, ophthalmic, cell encapsulation, and wound healing [1] . The structural morphology demonstrate that macromolecular polymer gels formulated of cross‐linked polymer networks exhibit effectiveness towards various requisitions [212–215] . Pietramaggiori et al fabricated a matrix system through Poly‐N‐acetyl glucosamine hydrogel obtained from microalgae [216] .…”

Section: Biopolymer Centered Materials For Different Biomedical Applimentioning

confidence: 99%

“…[1] The structural morphology demonstrate that macromolecular polymer gels formulated of cross-linked polymer networks exhibit effectiveness towards various requisitions. [212][213][214][215] Pietramaggiori et al fabricated a matrix system through Poly-N-acetyl glucosamine hydrogel obtained from microalgae. [216] The developed hydrogel matrix is approved by Food and Drug Administration for treating the patients suffering from diabetic foot ulcers.…”

Section: Hydrogelsmentioning

confidence: 99%

Multifunctional Biopolymers‐Based Composite Materials for Biomedical Applications: A Systematic Review

2021

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Biopolymers are considered as a favorable group of substances with a broad array of applications, of which biomedical field stands out. The interesting features of biopolymers such as low‐cost, non‐cytotoxicity, hydrophilicity, biodegradation and biocompatibility make them promising and excellent feedstock to be used in implantable devices. The bounteous reactive functional groups in the backbone structure of polysaccharides and its derivatives could be utilized to develop hydrogels, nano‐composite and 3D scaffolds with appealing structures and desired features, leading to promising research attention towards biomedical fields. The present review describes the foremost properties as well as potential of different biopolymers, and their composites for application in implantable biomedical systems. This work may introduce readers about the comprehension of state‐of‐the‐art advances, real present challenges along with the future anticipation of eco‐friendly and biomimetic techniques for the modification of biopolymeric materials to improve their biomedical applications.

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“…In an another pK study reported by Peng et al (2013), an HPLC method has been employed for the determination of VEN in rabbits after injecting a VEN saline solution and thermosensitive VEN-chitosan hydrogel subcutaneously 42 . Ali et al (2019) has also employed an HPLC-UV method for pK studies of VEN containing oral solution and sustained release hydrogel composites in rabbits 43 . An HPLC-UV method developed and validated in rabbit plasma by Sher et al (2020) has been applied to pK analysis of VEN in albino rabbits after its oral administration 44 .…”

Section: Venlafaxine (Ven) (Rs) 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol Which Belongs Tomentioning

confidence: 99%

Tandem Mass Spectrometry (MS/MS) in the Preclinical Pharmacokinetic Study of a Highly Prescribed SNRI Drug for Depression and Its Application to Oral Extended Release Solid Dosage Formulations in Rabbits

Fazli

Panigrahy

Kumar

et al. 2021

Preprint

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Preclinical pharmacokinetic (pK) studies in animal models during the formulation development phase give preliminary evidence and near clear picture of the pK behavior of drug and/or its dosage forms prior to clinical studies on humans and help in tailoring of the dosage form according to the expected and requisite clinical behavior. The present work reports first of its kind preclinical pK study on oral extended release (ER) solid dosage formulations of venlafaxine (VEN) in New Zealand White rabbits. The VEN is a highly prescribed and one of the safest and most effective therapeutic agents used in the treatment different types of depression disorders worldwide. The LC-MS/MS bioanalytical method developed for this purpose demonstrated enough reliability in simultaneously quantitating VEN and its equipotent metabolite O-desmethylvenlafaxine (ODV) in rabbit plasma. The method described uses solid phase extraction for sample preparation followed by an ultra-fast LC-MS/MS analysis. The chromatographic separation was achieved isocratically with a predominantly polar mobile phase by employing RPLC. The triple quadrupole LC/MS/MS system operated in MRM mode used an ESI probe as an ion source in positive polarity. The validation results are within the permissible limits of US FDA recommendations and acceptance criteria for bioanalytical method validation.

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Venlafaxine-loaded sustained-release poly(hydroxyethyl methacrylate-co-itaconic acid) hydrogel composites: their synthesis and in vitro/in vivo attributes

Cited by 10 publications

References 24 publications

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

Multifunctional Biopolymers‐Based Composite Materials for Biomedical Applications: A Systematic Review

Tandem Mass Spectrometry (MS/MS) in the Preclinical Pharmacokinetic Study of a Highly Prescribed SNRI Drug for Depression and Its Application to Oral Extended Release Solid Dosage Formulations in Rabbits

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