Venlafaxine extended-release treatment of hoarding disorder

Saxena, Sanjaya; Sumner, Jennifer

doi:10.1097/yic.0000000000000036

Cited by 60 publications

(43 citation statements)

References 75 publications

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“…[47][48][49] Psicoterapia Pelo nosso conhecimento, existem quatro revisões sobre o tratamento psicoterápico das dificuldades relacionadas à acumulação. 47 55 Em uma série de casos, 4 pacientes com TA sem TDAH comórbido foram tratados com metilfenidato de liberação controlada por 4 semanas (dose média de 50 ± 9 mg/ dia). Dois participantes tiveram redução modesta dos sintomas de acumulação mensurados pelo SI-R (25 e 32%), especialmente em relação à aquisição excessiva.…”

Section: Tratamentounclassified

Transtorno de acumulação: uma revisão

Stumpf¹,

Hara²,

Rocha³

2018

Geriatr., Gerontol. Aging

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a resuMo O transtorno de acumulação (TA) pode ser definido como uma dificuldade persistente de desfazer-se de itens devido ao sofrimento associado com o descarte ou uma necessidade percebida de guardar posses a despeito de seu valor real. Tal comportamento pode resultar no acúmulo de objetos, o que compromete significativamente o uso da moradia, causando sofrimento e/ou prejuízo funcional. Os itens acumulados mais frequentemente são objetos e animais. A prevalência do transtorno é de 1,5 a 2,1% na população em geral, podendo ser maior que 6% em idosos. O TA causa riscos à saúde e à segurança dos indivíduos, especialmente dos idosos, gerando um custo relevante para a sociedade. O diagnóstico de TA é clínico e só deve ser feito após a exclusão de condições médicas gerais e outros transtornos mentais que podem levar ao acúmulo de objetos. O TA parece ser um transtorno de curso crônico e progressivo, comumente associado a comorbidades psiquiátricas. Estudos indicam a participação de fatores genéticos, familiares, cognitivos e de experiências traumáticas na etiologia do TA. A abordagem terapêutica mais estudada até o momento foram as psicoterapias, mas os resultados mostram efeito pequeno. Os estudos farmacológicos existentes são muito incipientes, não permitindo conclusões de eficácia. PALAVRAS-CHAVE: transtorno de acumulação; colecionismo; psicopatologia. aBstractHoarding disorder can be defined as a persistent difficulty in discarding items, due to distress associated with such disposal or a perceived need to save items regardless of their actual value. Such behavior must result in the accumulation of clutter, which significantly compromises living conditions, causing distress and/or functional impairment. The most frequently hoarded items are objects and animals. The point prevalence of clinically significant hoarding was estimated to be 1.5 to 2.1% in the general population, and may exceed 6% in the elderly. HD poses a range of health and safety hazards to individuals, especially older adults, generating significant costs to society. The diagnosis of HD is clinical, and should only be established after general medical conditions and other mental disorders that can lead to accumulating behavior have been ruled out. HD appears to follow a chronic, progressive course, and is commonly associated with psychiatric comorbidities. Studies indicate that genetic, familial, cognitive, and traumatic factors are implicated in the etiology of HD. To date, psychotherapies have been the most widely studied therapeutic approaches, but the results of these studies show small effects. Research into pharmacological approaches to HD is still incipient, precluding any conclusions of efficacy.

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Section: Tratamentounclassified

Transtorno de acumulação: uma revisão

Stumpf¹,

Hara²,

Rocha³

2018

Geriatr., Gerontol. Aging

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“…Selective serotonin reuptake inhibitors [13][14][15][16], Serotoninnorepinephrine reuptake inhibitors [17], Central nervous system stimulants [18] and atypical antipsychotic agents [19] have been administered for HD, but results from pharmaceutical treatment trials for hoarding are equivocal.…”

Section: Pharmaceutical Treatmentmentioning

confidence: 99%

Untitled

2016

JPCPY

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Background and aims: Non-pharmaceutic approaches to the treatment of hoarding disorder (HD) use interventions based of cognitive-behavioral therapy (CBT). Inference-based therapy (IBT) focuses on the doubts which form the basis of preoccupation in HD and deals with ego syntonic values in hoarding by exposing how the hoarding-self sabotages the authentic self. The objective was to establish if the IBT would lead to the clinically significant decrease of hoarding symptoms.

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“…29 A similar small openlabel study of 24 patients suggested extended-release venlafaxine may be effective for the treatment of hoarding disorder and was well tolerated. 30 Authors of a small case series which examined the effectiveness of methylphenidate in patients with significant hoarding. However, only 2 out of 4 patients in the series demonstrated benefit, and the results were modest.…”

Section: Pharmacotherapymentioning

confidence: 99%