Venlafaxine compromises the antinociceptive actions of gabapentin in rat models of neuropathic and persistent pain

Abstract

Venlafaxine compromises the antiallodynic effects of coadministered gabapentin most probably as consequence-increased diuresis.

Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats

“…Behavioral tests were performed using two tests: the tailflick test (a spinal reflex test) and the paw-withdrawal test (which involves the higher centers). Gabapentin dosages were chosen according to previous studies in which it was shown to treat neuropathic pain in rats [19,20]. Gabapentin was injected twice daily considering the elimination half life [21].…”

Antinociceptive evaluation of ceftriaxone and minocycline alone and in combination in a neuropathic pain model in rat

“…With the combination of suitable drugs we are able to use submaximal doses with fewer adverse effects and to obtain more benefit from greater efficacy (Dworkin et al, 2007). Nevertheless, combination of two drugs with different mechanisms of action will not always have a desirable consequence (Malyshkin et al, 2005;Rode et al, 2006).…”

Decoding spontaneous pain from brain cellular calcium signals using deep learning

“…and venlafaxine (VX; 50 mg/kg, i.p.) 14 , which are clinically utilized analgesics, attenuated this spontaneous neuropathic pain at 3d, but not at 10d, following PSL ( Fig. 2c,d), whereas it relieved stimulus-evoked pain (mechanical allodynia) in both phases (Extended Fig.…”