Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats

Wei, Xin; Wei, Wei

doi:10.1007/s00540-011-1272-7

Cited by 16 publications

(9 citation statements)

References 34 publications

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“…This agrees with previous reports of “opioid-induced hyperalgesia” following regimens of opioid exposure in assays of acid-stimulated stretching in mice (Li et al, 2014) and in other preclinical assays of pain-stimulated behavior (Dong et al, 2006; Ross et al, 2012; Wei and Wei, 2012). Hyperalgesia after repeated treatment with morphine or other mu opioid agonists has also been reported in humans (De Conno et al, 1991; Chu et al, 2008; Lee et al, 2011).…”

Section: Discussionsupporting

confidence: 92%

Differential tolerance to morphine antinociception in assays of pain-stimulated vs. pain-depressed behavior in rats

Altarifi

Negus

2015

European Journal of Pharmacology

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In preclinical research on pain and analgesia, noxious stimuli can stimulate expression of some behaviors (e.g. withdrawal reflexes) and depress others (e.g. feeding, locomotion, and positively reinforced operant responding). Tolerance to morphine antinociception is a robust and reliable phenomenon in preclinical assays of pain-stimulated behavior, but development of morphine tolerance in assays of pain-depressed behavior has not been studied. This study compared morphine antinociceptive tolerance in parallel assays of pain-stimulated and pain-depressed behavior in male Sprague-Dawley rats. Intraperitoneal injection of dilute lactic acid served as a noxious stimulus to stimulate a stretching response in one group of rats and to depress operant responding for electrical brain stimulation (intracranial self-stimulation; ICSS) in another group of rats. Antinociception produced by morphine (1.0 mg/kg) was determined after a regimen of chronic treatment with either saline or morphine in separate subgroups of rats in each procedure. In rats receiving chronic saline, acid alone stimulated a stretching response and depressed ICSS, and both acid effects were blocked by 1.0 mg/kg morphine. Rats receiving chronic morphine displayed hyperalgesic responses to the acid noxious stimulus in both procedures. Complete tolerance developed to morphine antinociception in the assay of acid-stimulated stretching, but morphine retained full antinociceptive effectiveness in the assay of acid-depressed ICSS. These results suggest that morphine antinociception in an assay of pain-depressed behavior is relatively resistant to tolerance. More broadly, these results suggest that antinociceptive tolerance can develop at different rates or to different degrees for different measures of antinociception.

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Section: Discussionsupporting

confidence: 92%

Differential tolerance to morphine antinociception in assays of pain-stimulated vs. pain-depressed behavior in rats

Altarifi

Negus

2015

European Journal of Pharmacology

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“…6,39,60,68,73,80,112,133,134 Along with opioid, neurokinin 1, and toll-like receptor 4 antagonists, NSAIDS and gabapentinoids have been found to reduce neuroinflammation and mitigate OIH and/or WIH in some 1,5,14,18,34,45,46,61,70,83,85,94,100,121,127,135,137 but not all 50 circumstances. In our study, a subset of participants named NSAIDs most frequently and gabapentinoids third for relieving WISP, supporting a possible neuroinflammatory component.…”

Section: Discussionmentioning

confidence: 99%

Withdrawal-associated injury site pain (WISP): a descriptive case series of an opioid cessation phenomenon

Rieb

Norman

Martin

et al. 2016

Pain

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“…Table 1 summarises 27 remifentanil trials, while 14 fentanyl trials are summarised in Table 2 and 31 morphine trials are summarised in Table 3 . The trial by Wei and Wei [ 20 ] appears in two of the tables because the trial studied interventions for both FIH and MIH. The main characteristics presented are the first author, year of publication, intervention, study groups, intervention dose, administration method and injury model or opioid regimen used.…”

Section: Resultsmentioning

confidence: 99%

“…In six trials, the intervention was administered within a 30-min frame before fentanyl, and in four trials, the intervention was coadministered with fentanyl. Van Elstraete et al [ 24 ] and Wei and Wei [ 20 ] administered gabapentin 30 min before or 5 h after fentanyl administration. Li et al [ 40 ] administered KN93 6.5 h after fentanyl, whereas Kang et al [ 42 ] administered ketorolac 24 h after fentanyl.…”

Section: Resultsmentioning

confidence: 99%

Pharmacological Interventions for Opioid-Induced Hyperalgesia: A Scoping Review of Preclinical Trials

Koponen

Forget

2022

JCM

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Background: Opioid analgesics are the most effective pharmacological agents for moderate and severe pain. However, opioid use has several limitations such as opioid-induced hyperalgesia (OIH), which refers to the increased pain sensitivity that occurs once analgesia wears off after opioid administration. Several pharmacological interventions have been suggested for OIH, but the current literature does not provide guidelines on which interventions are the most effective and whether they differ depending on the opioid that induces hyperalgesia. This scoping review aimed to identify and describe all the preclinical trials investigating pharmacological interventions for OIH caused by remifentanil, fentanyl, or morphine as the first step towards evaluating whether the most effective OIH interventions are different for different opioids. Methods: Electronic database searches were carried out in Embase, PubMed, and Web of Science. Detailed data extraction was conducted on the eligible trials. Results: 72 trials were eligible for the review. Of these, 27 trials investigated remifentanil, 14 trials investigated fentanyl, and 31 trials investigated morphine. A total of 82 interventions were identified. The most studied interventions were ketamine (eight trials) and gabapentin (four trials). The majority of the interventions were studied in only one trial. The most common mechanism suggested for the interventions was inhibition of N-methyl-D-aspartate (NMDA) receptors. Conclusion: This scoping review identified plenty of preclinical trials investigating pharmacological interventions for OIH. Using the current literature, it is not possible to directly compare the effectiveness of the interventions. Hence, to identify the most effective interventions for each opioid, the interventions must be indirectly compared in a meta-analysis.

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Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats

Abstract: The study showed that gabapentin can significantly prevented opioid-induced hyperalgesia (OIH) induced caused by fentanyl and morphine, suggesting a role for the addition of gabapentin in the perioperative period and during chronic pain treatment as an effective drug to prevent OIH.

Cited by 16 publications

References 34 publications

Differential tolerance to morphine antinociception in assays of pain-stimulated vs. pain-depressed behavior in rats

Differential tolerance to morphine antinociception in assays of pain-stimulated vs. pain-depressed behavior in rats

Withdrawal-associated injury site pain (WISP): a descriptive case series of an opioid cessation phenomenon

Pharmacological Interventions for Opioid-Induced Hyperalgesia: A Scoping Review of Preclinical Trials

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