Velocity of Tracheal Muscus in Anesthetized Women Undergoing Gynecologic Surgery

Lichtiger, Monte; Landa, Jose; Hirsch, Judith A.

doi:10.1097/00000542-197506000-00024

Cited by 46 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…L ichtiger et al [145] studied the influence of intubation, premedication and humidification used for a routine surgical procedure on the TMV in 14 anaesthetized females undergoing gynaecological surgery. All the subjects were nonsmokers with no prior history of pulmonary disease or bronchitis.…”

Section: Anaesthesiamentioning

confidence: 99%

Effects of drugs on mucus clearance

Houtmeyers¹,

Gosselink²,

Gayan‐Ramirez³

et al. 1999

Eur Respir J

111

View full text Add to dashboard Cite

Mucociliary clearance (MCC), the process in which airway mucus together with substances trapped within are moved out of the lungs, is an important defence mechanism of the human body. Drugs may alter this process, such that it is necessary to know the effect of the drugs on MCC. Indeed, agents stimulating MCC may be used therapeutically in respiratory medicine, especially in patients suspected of having an impairment of their mucociliary transport system. In contrast, caution should be taken with drugs depressing MCC as an undesired side‐effect, independently of their therapeutic indication. Since cough clearance (CC) serves as a back‐up system when MCC fails, the influence of drugs must be examined not only on MCC but also on CC. Ultimately, the clinical repercussions of alterations in mucus transport induced by drug administration must be studied. Tertiary ammonium compounds (anticholinergics), aspirin, anaesthetic agents and benzodiazepines have been shown to be capable of depressing the mucociliary transport system. Cholinergics, methylxanthines, sodium cromoglycate, hypertonic saline, saline as well as water aerosol have been shown to increase MCC. Adrenergic antagonists, guaifenesin, S‐carboxymethylcysteine, sodium 2‐mercapto‐ethane sulphonate and frusemide have been reported not to alter the mucociliary transport significantly. Amiloride, uridine 5′‐triphosphate (UTP), quaternary ammonium compounds (anticholinergics), adrenergic agonists, corticosteroids, recombinant human deoxyribonuclease (rhDNase), N‐acetylcysteine, bromhexine and ambroxol have been reported either not to change or to augment MCC. Indirect data suggest that surfactant as well as antibiotics may improve the mucociliary transport system. As for the influence of drugs on CC, amiloride and rhDNase have been demonstrated to increase the effectiveness of cough. A trend towards an improved CC was noted after treatment with adrenergic agonists. The anticholinergic agent ipratropium bromide, which is a quaternary ammonium compound, has been suggested to decrease CC significantly. Bromhexine, ambroxol and neutral saline seemed not to alter CC, either positively or negatively. Finally, treatment with either amiloride, recombinant human deoxyribonuclease, bromhexine, ambroxol, N‐acetylcysteine, S‐carboxymethylcysteine or hypertonic saline has been suggested as a possible cause of clinical improvement in patients, such as the experience of dyspnoea, the case of expectoration or the frequency of infective exacerbations. Other agents did not show a clinical benefit. Eur Respir J 1999; 14: 452–467.

show abstract

Section: Anaesthesiamentioning

confidence: 99%

Effects of drugs on mucus clearance

Houtmeyers¹,

Gosselink²,

Gayan‐Ramirez³

et al. 1999

Eur Respir J

111

View full text Add to dashboard Cite

show abstract

“…Hierbei fand er eine dosisabhängige reversible Beeinträchtigung der trachealen Transportgeschwindigkeit. Beim Menschen wurde der Effekt einer Narkose auf die mukoziliäre Transportfunktion von Lichtiger et al untersucht [19]. In neueren in vitro-Untersuchungen führte Halothan zu einer Abnahme der ziliären Schlagfrequenz nasaler Zilienzellen [8,23].…”

Section: Diskussionunclassified

“…The mucociliary escalator of the lung is an important protective transport system by means of which inhaled particles and microorganisms are removed from the tracheobronchial system.In general, it is assumed that anaesthetics inhibit mucociliary clearance [3,5,6,19,27].In the present prospective study the effect of combination anaesthesia with isoflurane, fentanyl, vecuronium, and nitrous oxide-oxygen mixture on bronchial mucus transport velocity (BTV) was investigated. Patients and methods: 10 patients undergoing major abdominal surgery were included in the study.The study was approved by the ethics committee of our hospital.In all patients anaesthesia was induced with propofol (1-2 mg/kg), fentanyl (0,2-0,3 mg/kg) and vecuronium (0,1 mg/kg).After intubation anaesthesia was maintained with 1,5 MAC isoflurane and repeated doses of fentanyl (0,1-0,2 mg) and vecuronium.Ventilation was assisted with a 2:1 mixture of nitrous oxide and oxygen.The BTV was measured preoperatively in the conscious patients one day before surgery while they received local anaesthesia with 10 ml of 1 percent lidocaine and postoperatively while they received intubation anaesthesia.BTV was determined with a small volume of albumin microspheres labeled with technetium-99m, which was deposited on the dorsal surface at the lower ends of the right and left main bronchi via a catheter placed in the inner channel of a fibre-optic bronchoscope [15].…”

Section: Introductionmentioning

confidence: 98%

Kombinationsanästhesie und BTGEffekt einer Anästhesie mit Isofluran, Fentanyl, Vecuronium und Sauerstoff-Lachgas-Beatmung auf den bronchialen Schleimtransport

Konrad

Marx²,

Schraag³

et al. 1997

Anaesthesist

View full text Add to dashboard Cite

show abstract

“…Contributory effects may result from altered blood distribution and from impaired activity of the mucociliary system [9].…”

Section: Discussionmentioning

confidence: 99%

Pediatric pulmonary CT-scanning

Damgaard-Pedersen

Qvist

1980

Pediatr Radiol

View full text Add to dashboard Cite

Forty three lung scans, obtained in 29 anaesthetized children, were evaluated and compared with 85 scans performed in 52 sedated children. Confluent high absorptive areas in the lower parts of the lungs were found in 35 (81%) of the scans performed in children under general anaesthesia but such areas were not found in the scans performed under sedation.--For general anaesthesia, halothane-N2O-O2 was used in all but one patient. The radiological changes are presumably due to a fall in functional residual capacity with consequent airway closure.--It is important not to misinterpret these anaesthesia-induced pulmonary changes which may obscure or mimic true pathological lesions, such as parenchymal and pleural metastases.

show abstract

Velocity of Tracheal Muscus in Anesthetized Women Undergoing Gynecologic Surgery

Cited by 46 publications

References 0 publications

Effects of drugs on mucus clearance

Effects of drugs on mucus clearance

Kombinationsanästhesie und BTGEffekt einer Anästhesie mit Isofluran, Fentanyl, Vecuronium und Sauerstoff-Lachgas-Beatmung auf den bronchialen Schleimtransport

Pediatric pulmonary CT-scanning

Contact Info

Product

Resources

About