1983
DOI: 10.3109/03602538308991389
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Vehicle Effects in Percutaneous Absorption

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Cited by 76 publications
(18 citation statements)
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“…Only solubilized drug can diffuse within the vehicle and contribute significantly to release rate (Idson, 1983). Testosterone is more soluble in EtOH and PG, compared to PBS, enhancing the penetration of testosterone through equine stratum corneum.…”
Section: Discussionmentioning
confidence: 99%
“…Only solubilized drug can diffuse within the vehicle and contribute significantly to release rate (Idson, 1983). Testosterone is more soluble in EtOH and PG, compared to PBS, enhancing the penetration of testosterone through equine stratum corneum.…”
Section: Discussionmentioning
confidence: 99%
“…Dimethylsulfoxide vehicle enhanced percutaneous biopotency 10-fold, but plasma GnRH levels were not reported. Recent studies of this convenient and noninvasive route of drug administration (90,91) have demonstrated marked increases in skin absorption at certain anatomic sites such as the scrotum, scalp, and navel (92,93) and with the use of absorption-enhancing vehicles and occlusion (94). The hydrophobic and amphophilic properties of many of the recent GnRH analogs might be particularly favorable to percutaneous depot-release formulation and warrant further study.…”
Section: February 1986mentioning
confidence: 98%
“…This fact is owed to the lesser or greater viscosity, respectively (Idson 1983). According to the experimental data, the release from PLO is growing throughout time, reaching the maximum transfer at 3 hr.…”
Section: In Vitro Releasementioning
confidence: 89%