Preparation, characterization, and in vitro release of new transdermal methimazole as alternative to oral delivery

Morales, María Encarnación; Clares, Beatriz; López-Viota, Margarita; Ruíz, M. A.

doi:10.1080/10717540802035376

Cited by 9 publications

(1 citation statement)

References 33 publications

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“…This makes these hydrogels highly suitable for the transport and release of nonpolar drugs. [23][24][25] Mixtures of the block copolymer Pluronic F-127 with water forms nanoheterogenous networks with unpolar domains that dissolve significant amounts of organic substrate. [26] In this paper, we describe for the first time the use of Pluronic hydrogels as a nanosized polymer network for a photochemical reaction, that is, the photo-oxygenation of alkenes.…”

Section: Introductionmentioning

confidence: 99%

Singlet Oxygen Photo‐Oxygenation in Water/Pluronic F‐127 Hydrogels: Increased Reaction Efficiency Coupled with a Switch in Regioselectivity

Griesbeck

Uhlig²,

Sottmann

et al. 2012

Chemistry A European J

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Pluronic F-127 hydrogels are highly efficient microenvironments for photochemical reactions, as demonstrated for singlet oxygen reactions of monoalkenes. Nonpolar substrates are localized in the nanosized polymer compartment, which can be visualized by neutron scattering. The efficiency of (1)O(2) reactions is strongly increased for tiglate derivatives and the regioselectivity of the ene reaction of trisubstituted alkenes is completely switched in comparison with solution phase and inverted in comparison with intrazeolite photo-oxygenations.

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