VEGF-targeted magnetic nanoparticles for MRI visualization of brain tumor

Abstract

This work focuses on synthesis and characterization of targeted magnetic nanoparticles as magnetic resonance imaging (МRI) agents for in vivo visualization of gliomas. The authors utilize the fact that high-grade gliomas have extensive areas of necrosis and hypoxia, which results in increased secretion of angiogenesis vascular endothelial growth factor (VEGF). Monoclonal antibodies against vascular endothelial growth factor (mAbVEGF) were covalently conjugated to crosslinked BSA coated ferric oxide (Fe3O4) nanoparticles. The results show that these targeted nanoparticles are effective in MRI visualization of the intracranial glioma and may provide a new and promising contrast agent.

Development of biocompatible and VEGF-targeted paclitaxel nanodrugs on albumin and graphene oxide dual-carrier for photothermal-triggered drug delivery in vitro and in vivo

“…These may be caused by the PEG coating of the nanoparticles that can improve blood circulation duration and effectively decrease macrophage clearance of nanoparticles by the reticuloendothelial system, the enhanced permeability and retention (EPR) effect of solid tumor, as well as the mAbVEGF tumor targeting effect enhancing tumor accumulation. [44][45][46][47] According to the imaging diagnosis result, NIR irradiation treatment was conducted at 24 hours post-intravenous injection of samples. Intravenous injection of PTX-GHP-VEGF with or without 5-minute NIR irradiation exhibited a significant difference ( Figure 11A).…”

Magnetic iron oxide nanoparticles: Recent trends in design and synthesis of magnetoresponsive nanosystems

“…It was revealed that BSA coating greatly reduced the toxicity of nanoparticles and that the mitoxantrone drugloaded system exhibited excellent therapeutic potential in vitro. The surface of magnetite cores was directly coated with BSA and further cross-linked to improve colloidal stability [124]. Monoclonal antibodies against vascular endothelial growth factor (mAbVEGF) were covalently conjugated to BSA coating on IONPs, which are promising MRI contrast agents for glioma visualization in brain.…”

The Emerging Role of Nanotechnology in Cell and Organ Transplantation

“…Several promising nanoparticle-based imaging applications are currently in clinical trials, or expected to be in the near future, including nanoparticles for MRI contrast that target an integrin commonly found on the surface of newly developed vessels, and applying carbon nanotubes as possible x-ray sources for a new type of computed tomography scanner [133]. Nanoparticles with metallic components can be used as biosensors, for imaging capability with CT (such as super-paramagnetic iron oxide) in the attempt to better visualize cancer masses [134]. …”