Abstract:Breast cancer (BC) cells spread to secondary organs by exploiting lymphatic and blood vessels. Pro-angiogenic perivascular tumor-associated macrophages (TAMs) promote tumor cell intravasation and spreading to secondary organs by multiple mechanisms, including fueling tumor vessel abnormalization. Here, we show that perivascular TAMs expressing lymphangiogenic vascular endothelial growth factor (VEGF)-C normalize the tumor vasculature. This effect limited pulmonary metastases while enhancing lymph node metastas… Show more
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