Vegetable oils as green solvents in the pharmaceutical industry

Cheikhyoussef, Natascha; Cheikhyoussef, Ahmad

doi:10.1016/b978-0-12-821885-3.00017-7

Cited by 4 publications

(4 citation statements)

References 54 publications

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“…The pharmaceutical industry uses vegetable oils to extract phenolic compounds and carotenoids and formulate drug delivery systems and biopolymers [ 102 ]. In the present study, the solvent for the extraction of U. barbata secondary metabolites was canola oil (CNO).…”

Section: Discussionmentioning

confidence: 99%

ROS-Induced DNA-Damage and Autophagy in Oral Squamous Cell Carcinoma by Usnea barbata Oil Extract—An In Vitro Study

Popovici

Musuc

Matei

et al. 2022

IJMS

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Oxidative stress is associated with aging, cancers, and numerous metabolic and chronic disorders, and phenolic compounds are well known for their health-promoting role due to their free-radical scavenging activity. These phytochemicals could also exhibit pro-oxidant effects. Due to its bioactive phenolic secondary metabolites, Usnea barbata (L.) Weber ex. F.H. Wigg (U. barbata) displays anticancer and antioxidant activities and has been used as a phytomedicine for thousands of years. The present work aims to analyze the properties of U. barbata extract in canola oil (UBO). The UBO cytotoxicity on oral squamous cell carcinoma (OSCC) CLS-354 cell line and blood cell cultures was explored through complex flow cytometry analyses regarding apoptosis, reactive oxygen species (ROS) levels, the enzymatic activity of caspase 3/7, cell cycle, nuclear shrinkage (NS), autophagy (A), and synthesis of deoxyribonucleic acid (DNA). All these studies were concomitantly performed on canola oil (CNO) to evidence the interaction of lichen metabolites with the constituents of this green solvent used for extraction. The obtained data evidenced that UBO inhibited CLS-354 oral cancer cell proliferation through ROS generation (316.67 × 104), determining higher levels of nuclear shrinkage (40.12%), cell cycle arrest in G0/G1 (92.51%; G0 is the differentiation phase, while during G1 phase occurs preparation for cell division), DNA fragmentation (2.97%), and autophagy (62.98%) than in blood cells. At a substantially higher ROS level in blood cells (5250.00 × 104), the processes that lead to cell death—NS (30.05%), cell cycle arrest in G0/G1 (86.30%), DNA fragmentation (0.72%), and autophagy (39.37%)—are considerably lower than in CLS-354 oral cancer cells. Our work reveals the ROS-mediated anticancer potential of UBO through DNA damage and autophagy. Moreover, the present study suggests that UBO pharmacological potential could result from the synergism between lichen secondary metabolites and canola oil phytoconstituents.

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Section: Discussionmentioning

confidence: 99%

ROS-Induced DNA-Damage and Autophagy in Oral Squamous Cell Carcinoma by Usnea barbata Oil Extract—An In Vitro Study

Popovici

Musuc

Matei

et al. 2022

IJMS

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“…Pollen (INCI: Pollen) can be mixed into vegetable oils, such as sunflower oil or rice oil, to obtain pollen oil [24]. This preparation is rich in vitamins such as vitamin A, vitamin C, pantothenic acid, and flavonoids.…”

Section: Bee Derivativesmentioning

confidence: 99%

Zooceuticals and Cosmetic Ingredients Derived from Animals

Cristiano¹,

Guagni²

2022

Cosmetics

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Many substances derived from animals are used as ingredients in the cosmetic industry and constitute a particular type of product: zooceuticals. The main ingredients used can come from insects, such as snail slime; land animals, such as lanolin; and marine animals, such as marine collagen. Today, they are used less than in the past for hygienic–sanitary, ethical, and ecological reasons. Moreover, some can give rise to irritative or allergic dermatitis. However, they still represent a fraction of the common ingredients in certain types of cosmetic products today.

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“…Soybean oil (SO) comes under long-chain triglycerides (C16-C22). The oil serves as vegetable oil and is also used as fixed oil in many other cases [1]. Generally, oils have been categorized into two parts: fixed oil and volatile oil.…”

Section: Introductionmentioning

confidence: 99%

Soybean Oil: A Versatile Asset in Pharmaceutical Drug Delivery

Mohanty,

Behera,

Kumar Shaw

et al. 2024

Agricultural Sciences

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Soybean oil (SO), a lucrative and widely utilized vegetable oil, is used not only in the pharmaceutical industry but also to produce green diesel and several biomedical applications. SO is rich in healthy fats, including linoleic acid (54%), oleic acid (23%), palmitic acid (11%), linolenic acids (8%), and stearic acid (4%). Its high unsaturated fatty acid content makes it ideal for medicinal purposes. In topical application, SO provides anti-inflammatory and soothing benefits. The presence of SO in lipid-based medication improves the therapeutic efficacy and bioavailability of poorly water-soluble drugs. Its emulsifying properties support the development of Self-Emulsifying Drug Delivery Systems (SEDDS) and Self-Micro Emulsifying Drug Delivery Systems (SMEDDS), helping the oral administration of hydrophobic drugs. Additionally, soybean oil is included in total parenteral nutrition (TPN) solutions to provide essential fatty acids to patients unable to swallow. SO, biocompatibility, stability, and low toxicity make it a brilliant base for transcutaneous and topical delivery systems, enlightening the absorption of active medicinal ingredients. In gist, unique properties and a wide variety of applications make SO a star material in pharmaceuticals to enhance solubility, bioavailability, and the development of safe and effective drugs.

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Vegetable oils as green solvents in the pharmaceutical industry

Cited by 4 publications

References 54 publications

ROS-Induced DNA-Damage and Autophagy in Oral Squamous Cell Carcinoma by Usnea barbata Oil Extract—An In Vitro Study

ROS-Induced DNA-Damage and Autophagy in Oral Squamous Cell Carcinoma by Usnea barbata Oil Extract—An In Vitro Study

Zooceuticals and Cosmetic Ingredients Derived from Animals

Soybean Oil: A Versatile Asset in Pharmaceutical Drug Delivery

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