Vecuronium-Induced Depression of Phrenic Nerve Activity During Hypoxia in the Rabbit

Wyon, Nicholas; Eriksson, Lars; Yamamoto, Yuji; Lindahl, Sten G. E.

doi:10.1213/00000539-199606000-00026

Cited by 1 publication

(1 citation statement)

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“…Our main result of a specific depression of HVR but not HCVR with partial neuromuscular blockade is consistent with previous work and as previously shown is most likely due to an inhibition of synaptic acetylcholine‐dependent nicotinic chemotransmission within the carotid body. This is interesting because such separation of effects on hypoxic and hypercapnic stimuli usually implies a drug effect directly on the carotid body type‐1 glomus cell.…”

Section: Discussionsupporting

confidence: 93%

Hypoxic ventilatory response after rocuronium‐induced partial neuromuscular blockade in men with obstructive sleep apnoea

et al. 2019

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Obstructive sleep apnoea and residual neuromuscular blockade are, independently, known to be risk factors for respiratory complications after major surgery. Residual effects of neuromuscular blocking agents are known to reduce the hypoxic ventilatory response in healthy volunteers. Patients with obstructive sleep apnoea have impaired control of breathing, but it is not known to what extent neuromuscular blocking agents interfere with the regulation of breathing in such patients. In a physiological study in 10 unsedated men with untreated obstructive sleep apnoea, we wished to examine if partial neuromuscular blockade had an effect on hypoxic ventilatory response (isocapnic hypoxia to oxygen saturation of 80%) and hypercapnic ventilatory response (normoxic inspired carbon dioxide 5%). The hypoxic ventilatory response was reduced by 32% (p = 0.016) during residual neuromuscular block (rocuronium to train-of-four ratio 0.7), but the hypercapnic ventilatory response was unaffected. We conclude that neuromuscular blockade specifically depresses peripheral chemosensitivity, and not respiratory muscle function since the hypercapnic ventilatory response was unaffected.

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Section: Discussionsupporting

confidence: 93%