Vaspin, neutrophil gelatinase-associated lipocalin and apolipoprotein levels in patients with psoriatic arthritis

Çolak, Sabri; Omma, Ahmet; Sandıkçı, Sevinç Can; Yücel, Çiğdem; Omma, Tülay; Turan, Turhan

doi:10.4149/bll_2019_010

Cited by 14 publications

(8 citation statements)

References 60 publications

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“…Conversely, chemerin levels were significantly lower in PsA patients compared to healthy controls. Also, vaspin systemic levels were found higher in PsA patients compared to healthy controls, even though there was no significant correlation with disease activity, measured using the disease activity in PsA (DAPSA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Visual Analogue Scale (VAS), and Minimal Disease Activity (MDA) [100].…”

Section: Adipokines and Spamentioning

confidence: 88%

Adipokines and Chronic Rheumatic Diseases: from Inflammation to Bone Involvement

Cici

Corrado

Rotondo

et al. 2020

Clinic Rev Bone Miner Metab

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Besides its well-known role as energy storage tissue, adipose tissue is a biologically active tissue that can also be considered as an endocrine organ, as it is able to secrete adipokines. These bioactive factors, similar in structure to cytokines, are involved in several physiological and pathological conditions, such as glucose homeostasis, angiogenesis, blood pressure regulation, control of food intake, and also inflammation and bone homeostasis via endocrine, paracrine, and autocrine mechanisms. Given their pleiotropic functions, the role of adipokines has been evaluated in chronic rheumatic osteoarticular inflammatory diseases, particularly focusing on their effects on inflammatory and immune response and on bone alterations. Indeed, these diseases are characterized by different bone complications, such as local and systemic bone loss and new bone formation. The aim of this review is to summarize the role of adipokines in rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, osteoarthritis, and osteoporosis, especially considering their role in the pathogenesis of bone complications typical of these conditions.

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Section: Adipokines and Spamentioning

confidence: 88%

Adipokines and Chronic Rheumatic Diseases: from Inflammation to Bone Involvement

Cici

Corrado

Rotondo

et al. 2020

Clinic Rev Bone Miner Metab

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“…As a member of proinflammatory cytokines, it has been reported that IL-17 may be involved in the pathogenesis of psoriasis/PsA [2]. Some studies have demonstrated that IL-17 signaling pathways can induce LCN2 expression and secretion [8, 26]. Secretion of LCN2 can be regulated by IL-17 either alone or in conjunction with TNF- α [8, 27].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have demonstrated that IL-17 signaling pathways can induce LCN2 expression and secretion [8, 26]. Secretion of LCN2 can be regulated by IL-17 either alone or in conjunction with TNF- α [8, 27]. It suggests that LCN2 might play an important role in potential psoriasis/PsA pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, psoriasis has also been recognized as an independent risk factor for myocardial infarction, which may cause serious negative impact on the quality of life [7]. Psoriatic arthritis (PsA) is a chronic, inflammatory, and debilitating arthritis associated with psoriasis [8]. The etiology of psoriasis and PsA is unknown; some studies have shown that adipokines and cytokines may play an important role in its pathogenetic mechanisms [9, 10].…”

Section: Introductionmentioning

confidence: 99%

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Association of Serum Lipocalin-2 Concentrations with Psoriasis and Psoriatic Arthritis: An Updated Meta-Analysis

2019

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Objectives. The purpose of this study was to explore the association of serum lipocalin-2 concentrations with psoriasis and psoriatic arthritis (PsA). Methods. A systematic search of studies on the association of serum lipocalin-2 concentrations with psoriasis/PsA was conducted in PubMed, Web of Science, Elsevier ScienceDirect, and Cochrane Library. Eventually, 8 eligible studies were included. The strength of association between serum lipocalin-2 concentrations and psoriasis/PsA was assessed by pooled standard mean difference (SMD) with its 95% confidence intervals (CIs). Results. A total of 8 case-control studies, consisting of 349 psoriasis/PsA patients and 258 controls, were included in the meta-analysis. This meta-analysis showed significant association between serum lipocalin-2 concentrations and psoriasis/PsA in overall population (SMD: 0.757, 95%CI=0.588‐0.926, and PH=0.114; PH is the P value for the heterogeneity test). Similar results were found in subgroup analysis by ethnicity. Conclusions. Serum lipocalin-2 concentrations are higher in psoriasis/PsA patients than controls. However, more large-scale studies are warranted to explore the association between serum lipocalin-2 and the pathogenetic mechanisms of psoriasis/PsA.

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“…Systemically, serum levels of vaspin were found to be higher in psoriatic arthritis (PsA) patients compared to healthy controls [245], whereas levels were lower in OA patients compared to healthy controls [239]. In synovial fluid, vaspin levels were significantly higher in RA compared to OA patients with a tendency to correlate with DAS28 in the RA group [246].…”

Section: Other Adipokines In Oa and Ramentioning

confidence: 99%

The Adipokine Network in Rheumatic Joint Diseases

Carrión

Frommer

Pérez‐García

et al. 2019

IJMS

134

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Rheumatic diseases encompass a diverse group of chronic disorders that commonly affect musculoskeletal structures. Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two most common, leading to considerable functional limitations and irreversible disability when patients are unsuccessfully treated. Although the specific causes of many rheumatic conditions remain unknown, it is generally accepted that immune mechanisms and/or uncontrolled inflammatory responses are involved in their etiology and symptomatology. In this regard, the bidirectional communication between neuroendocrine and immune system has been demonstrated to provide a homeostatic network that is involved in several pathological conditions. Adipokines represent a wide variety of bioactive, immune and inflammatory mediators mainly released by adipocytes that act as signal molecules in the neuroendocrine-immune interactions. Adipokines can also be synthesized by synoviocytes, osteoclasts, osteoblasts, chondrocytes and inflammatory cells in the joint microenvironment, showing potent modulatory properties on different effector cells in OA and RA pathogenesis. Effects of adiponectin, leptin, resistin and visfatin on local and systemic inflammation are broadly described. However, more recently, other adipokines, such as progranulin, chemerin, lipocalin-2, vaspin, omentin-1 and nesfatin, have been recognized to display immunomodulatory actions in rheumatic diseases. This review highlights the latest relevant findings on the role of the adipokine network in the pathophysiology of OA and RA.

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Vaspin, neutrophil gelatinase-associated lipocalin and apolipoprotein levels in patients with psoriatic arthritis

Cited by 14 publications

References 60 publications

Adipokines and Chronic Rheumatic Diseases: from Inflammation to Bone Involvement

Adipokines and Chronic Rheumatic Diseases: from Inflammation to Bone Involvement

Association of Serum Lipocalin-2 Concentrations with Psoriasis and Psoriatic Arthritis: An Updated Meta-Analysis

The Adipokine Network in Rheumatic Joint Diseases

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