Association of Serum Lipocalin-2 Concentrations with Psoriasis and Psoriatic Arthritis: An Updated Meta-Analysis

Wang, Dingjian; Fang, Lanlan; Pan, Guixia

doi:10.1155/2019/7361826

Cited by 16 publications

(12 citation statements)

References 31 publications

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“…This study identified a significant increase in serum and tissue LCN2 of patients when compared with healthy controls. Our results regarding serum LCN2 are in accordance with few previous studies 2,3,7,8 . The role of LCN2 in psoriasis remains unclear.…”

Section: Discussionsupporting

confidence: 91%

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Evaluation of tissue and serum lipocalin 2 in psoriasis vulgaris and its implications on subclinical atherosclerosis

Hassab-El-Naby

Helal

Abdou

et al. 2021

Dermatological Reviews

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Lipocalin‐2 (LCN2) has been identified as an adipokine but its role in psoriasis has not been fully elucidated. The study aimed to evaluate serum and tissue levels of LCN2 in patients with plaque‐type psoriasis and its correlation with C‐reactive protein (CRP), disease duration, severity, and subclinical atherosclerosis. Thirty patients with psoriasis and another 15 healthy age and sex matching controls were included and LCN2 was assessed in serum and tissue from patients and controls. Total lipid profile and high‐sensitivity CRP were also measured. Carotid artery intima media thickness was determined by using high‐resolution mode ultrasound in both patients and controls. Results showed statistically higher serum and tissue levels of LCN2 in patients than controls (p = .009 and p = .025, respectively). A significant difference in the right and left IMT was noted between patients and controls (p = .02 and p = .04). In conclusion, patients with psoriasis are found to be at increased risk of atherosclerosis.

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Section: Discussionsupporting

confidence: 91%

“…More recently LCN2 was linked to atherosclerosis. In both atherosclerotic plaques and the intima of injured vessels, LCN2 localizes with matrix metalloproteinase‐9, a key protease in inflammation and atherosclerosis 2–4 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of tissue and serum lipocalin 2 in psoriasis vulgaris and its implications on subclinical atherosclerosis

Hassab-El-Naby

Helal

Abdou

et al. 2021

Dermatological Reviews

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“…In addition, Baran et al noticed a significant positive correlation between irisin in psoriasis patients and laboratory parameters of inflammation, namely CRP and ESR, as well as lipocalin-2 [ 26 ], a protein secreted mainly by activated neutrophils that has been associated with inflammatory responses and described as elevated in psoriasis [ 31 ]. The results obtained by these authors suggested that irisin should not be considered an indicator of metabolic conditions, severity of psoriasis or efficacy of antipsoriatic treatment but might be a marker of inflammation in psoriatic patients [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis

et al. 2022

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Irisin is an adipo-myokine, mainly synthetized in skeletal muscles and adipose tissues, that is involved in multiple processes. Only a few studies have evaluated serum irisin in psoriatic patients. This study aims to analyze serum irisin levels in patients with chronic plaque psoriasis, to compare them with values in controls, and to assess whether concentration of circulating irisin correlates with the severity of psoriasis, calculated by means of Psoriasis Area and Severity Index (PASI). We enrolled 46 patients with chronic plaque psoriasis; the control group included 46 sex- and age-matched subjects without any skin or systemic diseases. Serum irisin levels were measured by competitive enzyme linked immunosorbent assay. Our results showed a non-significant increase in serum irisin concentration in psoriatic patients compared to controls. A negative non-linear correlation between PASI and irisin levels was detected in psoriatic patients. Indeed, dividing patients according to psoriasis severity, the negative association between irisin and PASI was stronger in patients with mild psoriasis than in patients with higher PASI scores. Several control variables we tested showed no significant impact on serum irisin. However, erythrocyte sedimentation rate in the normal range was associated with significantly higher irisin levels in psoriatic patients. In conclusion, although irisin levels were not significantly different between controls and psoriatic patients, irisin was found to be negatively associated with psoriasis severity, especially in subjects with low PASI scores; however, further studies are needed to clarify the role of irisin in subjects with psoriasis.

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“…Besides cytokines, chemoattractant molecules such as S100a9, Lcn2 and Tslp are increased in DKO* mice and in patients. 9,31,[39][40][41] These molecules are considered antimicrobial peptides, and one of the multiple functions is to attract immune cells towards lesional skin, such as neutrophils to kill pathogens. 42 Interestingly, neutrophils were highly recruited in psoriasis plaques and other neutrophil- Studies in vitro confirmed that FIB-116 acts directly on stimulated keratinocytes inhibiting their proliferation and pro-inflammatory response associated with TSLP, an important mediator in psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Topical application of an amygdalin analogue reduces inflammation and keratinocyte proliferation in a psoriasis mouse model

Gago-López

Arnal

Pérez

et al. 2021

Experimental Dermatology

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Psoriasis is a chronic inflammatory skin disease without cure. Systemic and biological therapies are the most effective treatments for patients with severe psoriasis.However, these drugs can cause serious side effects from extended use. Safe and effective topical drugs are needed to decrease psoriatic plaques and reduce the risk of adverse effects. Amygdalin analogues are stable small molecules that showed benefits in psoriasis xenografts to immune-deficient mice by systemic application. However, whether topical application of these amygdalin analogues could reduce the progression of the psoriatic phenotype in an immune-competent organism is unknown. Here, we analyse the efficiency of topical application of an amygdalin analogue cream on a well-established genetic and immune-competent mouse model of psoriasis. Topical application of an amygdalin analogue cream ameliorates psoriasis-like disease in mice, reduces epidermal hyperplasia and skin inflammation. Amygdalin analogue treatment leads to reduced expression of local pro-inflammatory cytokines, but systemic proinflammatory cytokines that are highly expressed in psoriasis patients such as IL-17A, IL6 or G-CSF are also decreased. Furthermore, expression of important mediators of psoriasis initiation and epidermal hyperplasia, such as TNFa, S100A9 and TSLP, is decreased in lesional epidermis after amygdalin analogue treatment. In conclusion, we show that amygdalin analogue reduces the proliferative capacity of psoriasis-like stimulated keratinocytes and their inflammatory response in vivo and in vitro. These results suggest that topical application of amygdalin analogues may represent a safe and effective treatment for psoriasis.

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Association of Serum Lipocalin-2 Concentrations with Psoriasis and Psoriatic Arthritis: An Updated Meta-Analysis

Cited by 16 publications

References 31 publications

Evaluation of tissue and serum lipocalin 2 in psoriasis vulgaris and its implications on subclinical atherosclerosis

Evaluation of tissue and serum lipocalin 2 in psoriasis vulgaris and its implications on subclinical atherosclerosis

Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis

Topical application of an amygdalin analogue reduces inflammation and keratinocyte proliferation in a psoriasis mouse model

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