Vasorelaxation by casomokinin L, a derivative of β-casomorphin and casoxin D, is mediated by NK1 receptor

Fujita, Hiroyuki; Suganuma, Hiroyuki; Usui, Hachiro; Kurahashi, Kazuyoshi; Nakagiri, Ryusuke; Sasaki, Ryuzo; Yoshikawa, Masaaki

doi:10.1016/0196-9781(96)00067-8

Cited by 21 publications

(14 citation statements)

References 20 publications

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“…Other studies have highlighted the existence of vasorelaxant opioid peptides arising from b-Lg such as b-Lg f102-105, named b-lactorphin, YLLF and from human casein, as casoxin D, YVPFPPF, and casokinin L, YPFPPL (Fujita et al, 1996). Similarly, peptides derived from the hydrolysis of other food proteins, such as ovalbumin (ovokinin, FRADHPFL, and ovokinin 2-7, RADHPF) lowered blood pressure in SHR through different modes of vasorelaxing activity (Matoba, Usui, Fujita, & Yoshikawa, 1999).…”

Section: Other Possible Mechanisms Of Actionmentioning

confidence: 96%

Physiological, chemical and technological aspects of milk-protein-derived peptides with antihypertensive and ACE-inhibitory activity

López‐Fandiño

Otte

Camp

2006

International Dairy Journal

328

227

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Section: Other Possible Mechanisms Of Actionmentioning

confidence: 96%

Physiological, chemical and technological aspects of milk-protein-derived peptides with antihypertensive and ACE-inhibitory activity

López‐Fandiño

Otte

Camp

2006

International Dairy Journal

328

227

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“…It is noteworthy that NO is regarded as an important signaling molecule in vasodilation, neurotransmission, and host immune defense (Ahn et al, 2012) and peptides from whey protein (Ballard et al, 2009), Aa-lactabumin and Ab-lactabumin (Sipola et al, 2002), ovalbumin (Matoba et al, 1999), flaxseed protein (Udenigwe and Aluko, 2012), skeletal muscle protein (Takahashi et al, 2009), and even human casein (Fujita et al, 1996) were found to enhance NO production.…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

Peptides: Production, bioactivity, functionality, and applications

Hajfathalian

Ghelichi

Moreno

et al. 2017

Critical Reviews in Food Science and Nutrition

133

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Production of peptides with various effects from proteins of different sources continues to receive academic attention. Researchers of different disciplines are putting increasing efforts to produce bioactive and functional peptides from different sources such as plants, animals, and food industry by-products. The aim of this review is to introduce production methods of hydrolysates and peptides and provide a comprehensive overview of their bioactivity in terms of their effects on immune, cardiovascular, nervous, and gastrointestinal systems. Moreover, functional and antioxidant properties of hydrolysates and isolated peptides are reviewed. Finally, industrial and commercial applications of bioactive peptides including their use in nutrition and production of pharmaceuticals and nutraceuticals are discussed.

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“…The peptide corresponds to hemoglobin -chain (105)(106)(107)(108)(109)(110)(111)(112)(113)(114)(115)(116) and was named hemotensin. Many kinds of antimicrobial peptides were reported to be released from hemoglobin [50].…”

Section: B) Blood Proteinsmentioning

confidence: 99%

“…Hybrid ligands for 2 different kind of receptor such as casokinins -F and -L were also obtained [106,107].…”

Section: D) Rapeseed Proteinsmentioning

confidence: 99%

Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects

Yoshikawa

2015

Peptides

Self Cite

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We have found various bioactive peptides derived from animal and plant proteins, which interact with receptors for endogenous bioactive peptides such as opioids, neurotensin, complements C3a and C5a, oxytocin, and formyl peptides etc. Among them, rubiscolin, a δ opioid peptide derived from plant RuBisCO, showed memory-consolidating, anxiolytic-like, and food intake-modulating effects. Soymorphin, a μ opioid peptide derived from β-conglycinin showed anxiolytic-like, anorexigenic, hypoglycemic, and hypotriglyceridemic effects. β-Lactotensin derived from β-lactoglobulin, the first natural ligand for the NTS2 receptor, showed memory-consolidating, anxiolytic-like, and hypocholesterolemic effects. Weak agonist peptides for the complements C3a and C5a receptors were released from many proteins and exerted various central effects. Peptides showing anxiolytic-like antihypertensive and anti-alopecia effects via different types of receptors such as OT, FPR and AT2 were also obtained. Based on these study, new functions and post-receptor mechanisms of receptor commom to endogenous and exogenous bioactive peptides have been clarified.

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Vasorelaxation by casomokinin L, a derivative of β-casomorphin and casoxin D, is mediated by NK1 receptor

Cited by 21 publications

References 20 publications

Physiological, chemical and technological aspects of milk-protein-derived peptides with antihypertensive and ACE-inhibitory activity

Physiological, chemical and technological aspects of milk-protein-derived peptides with antihypertensive and ACE-inhibitory activity

Peptides: Production, bioactivity, functionality, and applications

Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects

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