Vasorelaxant and Hypotensive Effects of Cheonwangbosimdan in SD and SHR Rats

Kim, Bumjung; Jo, Cheolmin; Choi, Ho Young; Lee, Kyungjin

doi:10.1155/2018/6128604

Cited by 9 publications

(4 citation statements)

References 22 publications

(14 reference statements)

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“…CBD has also been shown to reduce inflammatory responses [41] and improve sleep quality in patients with primary insomnia [42]. Furthermore, it exhibits neuroprotective [43], vasorelaxant, hypotensive [44], and anti-Alzheimer's disease [45,46] effects. It is commonly prescribed for alleviating the psychological and behavioral symptoms of dementia related to Alzheimer's disease [47].…”

Section: Discussionmentioning

confidence: 99%

Herbal Medicines for Long COVID: A Phase 2 Pilot Clinical Study

Kim,

Yoon,

Kim

et al. 2024

Preprint

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Background: Infections of Coronavirus Disease-2019 (COVID-19) can cause long-term effects known as long COVID. This pilot study aimed to evaluate the feasibility of a clinical study as well as the efficacy and safety of traditional East Asian herbal medicines in alleviating fatigue and cognitive dysfunction “brain fog” in patients with long COVID. Methods: This prospective pilot study investigated the use of three types of herbal medicines, Bojungikki-tang (BIT), Kyungok-go (KOG), and Cheonwangbosim-dan (CBD), for a 12-week period as potential treatments for fatigue and cognitive dysfunction in patients with long COVID. Forty-five patients with long COVID were recruited, and one of three drugs was given based on the patient’s symptoms and pattern identification. The effect of herbal medications on fatigue and cognitive function outcomes was assessed over a 36-week period, with patient adherence closely monitored. Results: After 12 weeks of herbal drug administration, fatigue symptoms improved significantly across all groups, with treatment success rates of 80%, 53.33%, and 46.67% in the BIT, KOG, and CBD groups, respectively. However, “brain fog” symptoms showed less improvement, with treatment success rates of 40%, 46.67%, and 13.33% in the BIT, KOG, and CBD groups, respectively. All adverse events reported were mild and unrelated to the medication. The study design was found to be feasible with high medication adherence. Conclusions: This study demonstrated the feasibility of conducting a clinical trial with three herbal medicines to treat long COVID symptoms like fatigue and “brain fog.”

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Section: Discussionmentioning

confidence: 99%

Herbal Medicines for Long COVID: A Phase 2 Pilot Clinical Study

Kim,

Yoon,

Kim

et al. 2024

Preprint

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“…Atorvastatin [ 31 ], a lipid-lowering agent that blocks cholesterol synthesis; aliskiren [ 32 ], an inhibitor that reduces the activation of the renin-angiotensin aldosterone system (RAAS); hydrochlorothiazide [ 32 ], a thiazide diuretic; benazepril and perindopril [ 33 ], angiotensin-converting enzyme inhibitors; and olmesartan, telmisartan, and valsartan [ 34 ], the angiotensin-II receptor blockers; are commonly used in combination with amlodipine. In addition, cheonwangbosimdan, a traditional herbal medicine, was co-administered with amlodipine and showed high vasodilatory and blood pressure-lowering effects [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Co-Administration of Curcumin with Amlodipine in Hypertension

Lee

Choi

et al. 2021

Nutrients

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Curcumin, a curcuminoid known as the main bioactive compound of turmeric, is used in foods, cosmetics, and pharmaceutical products. Amlodipine is a general antihypertensive drug used in combination with various other antihypertensive agents. To date, no studies have examined the effects of the co-administration of amlodipine with curcumin. In this study, the vasodilatory effects of curcumin, amlodipine, and the co-administration of curcumin with amlodipine on isolated rat aortic rings pre-contracted with phenylephrine were evaluated, and the hypotensive effects were evaluated using the tail cuff method. To measure blood pressure, male spontaneously hypertensive rats were divided into four groups, each containing six rats, as follows: amlodipine 1 mg/kg alone treated, amlodipine 1 mg/kg with curcumin 30 mg/kg treated, amlodipine 1 mg/kg with curcumin 100 mg/kg treated, and amlodipine 1 mg/kg with curcumin 300 mg/kg treated groups. Amlodipine and curcumin were intraperitoneally injected, and systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured at 1, 2, 4, and 8 h after administration. The combined administration of curcumin and amlodipine induced a stronger vasorelaxant effect than amlodipine alone. However, co-administration did not significantly lower SBP and DBP compared to the single administration of amlodipine. The results of this study suggest that hypertensive patients taking amlodipine can consume curcumin or turmeric for food or other medical purposes without inhibiting the blood pressure-lowering effect of amlodipine.

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“…The traditional herbal medicine Cheonwangbosim-dan (known as Tianwang-buxin-dan in China and Tennou-hoshin-tan in Japan) consists of 15 different herbs and has been widely used for the treatment of insomnia, neurosis, cardiac malfunction-induced disease, and arterial or auricular flutter in East Asian countries [ 4 ]. Previous studies have demonstrated that Cheonwangbosim-dan exerts a variety of biological activities including anti-inflammatory [ 5 ], vasorelaxant, and hypotensive effects [ 6 ]. In order to identify and optimize potential herbal decoctions, we performed a therapeutic screening of various herbal medicines including Cheonwangbosim-dan.…”

Section: Introductionmentioning

confidence: 99%