Effect of Co-Administration of Curcumin with Amlodipine in Hypertension

Abstract

Curcumin, a curcuminoid known as the main bioactive compound of turmeric, is used in foods, cosmetics, and pharmaceutical products. Amlodipine is a general antihypertensive drug used in combination with various other antihypertensive agents. To date, no studies have examined the effects of the co-administration of amlodipine with curcumin. In this study, the vasodilatory effects of curcumin, amlodipine, and the co-administration of curcumin with amlodipine on isolated rat aortic rings pre-contracted with phenylephrine were evaluated, and the hypotensive effects were evaluated using the tail cuff method. To measure blood pressure, male spontaneously hypertensive rats were divided into four groups, each containing six rats, as follows: amlodipine 1 mg/kg alone treated, amlodipine 1 mg/kg with curcumin 30 mg/kg treated, amlodipine 1 mg/kg with curcumin 100 mg/kg treated, and amlodipine 1 mg/kg with curcumin 300 mg/kg treated groups. Amlodipine and curcumin were intraperitoneally injected, and systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured at 1, 2, 4, and 8 h after administration. The combined administration of curcumin and amlodipine induced a stronger vasorelaxant effect than amlodipine alone. However, co-administration did not significantly lower SBP and DBP compared to the single administration of amlodipine. The results of this study suggest that hypertensive patients taking amlodipine can consume curcumin or turmeric for food or other medical purposes without inhibiting the blood pressure-lowering effect of amlodipine.

Polyphenols as Plant-Based Nutraceuticals: Health Effects, Encapsulation, Nano-Delivery, and Application

“…A report by Huang et al [ 68 ] described in detail the beneficial effects of flavonoids, flavanols, anthocyanins, phenolic acids, tannins, resveratrol, and other polyphenolic compounds on vasodilation and other aspects of blood pressure control. In another study, researchers evaluated the vasodilatory effects of curcumin, amlodipine, and curcumin and amlodipine in combination on isolated rat aortic rings, and found that hypertensive patients taking amlodipine could consume curcumin or turmeric for food or other medical purposes without inhibiting the antihypertensive effects of amlodipine [ 65 ]. This provides a valuable basis for the use of curcumin and other polyphenolic compounds with antihypertensive effects as food ingredients for the prevention and treatment of hypertension.…”

Curcumin - The Nutraceutical With Pleiotropic Effects? Which Cardiometabolic Subjects Might Benefit the Most?

“…Interestingly, in an experimental study by Lee et al it was shown that co-administration of amlodipine and curcumin had a stronger vasorelaxant effect than amlodipine alone. Thus, the use of curcumin and amlodipine may be an effective antihypertensive combination ( 120 ).…”

The Review: The Discovery and Development of Amlodipine Drug

“…Amlodipine and curcumin were injected intraperitoneally; no side effects were observed after concurrent administration 29 . The effect of amlodipine of 0.1-3.0 mg/kg on suppressed rats, amlodipine was administered to two groups of rats consuming alcohol: one group that regularly consumed sweetened alcoholic beverages and the other consumed unsweetened alcoholic beverages.…”