Vasorelaxant and cardiovascular properties of the essential oil of Pogostemon elsholtzioides

Kumar, Arumugasamy Shiva; Jeyaprakash, K.; Chellappan, David Raj; Murugan, Ramar

doi:10.1016/j.jep.2017.01.036

Cited by 21 publications

(6 citation statements)

References 10 publications

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“…In this study, we suggested that the high content of curzerene in the myrrh may have an influential role in the possibility of the myrrh extract in reducing ethanol toxicity and improving testicular tissue. This suggestion is compatible with previous in-vivo and in-vitro studies (Wang et al, 2017;Kumar et al, 2017). Also, other studies have demonstrated that some essential oils containing curzerene as a major component showed significant antioxidant activity against free radicals from exposure to toxins (Li et al, 2010).…”

Section: Myrrh Attenuates Gonadal Toxicity and Dna Fragmentation Indu...supporting

confidence: 91%

Myrrh Attenuates Gonadal Toxicity and DNA Fragmentation Induced by Ethanol in Male Rats

Alahmari

2023

IJAR

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Background: Long-term ethanol consumption causes pathological alterations to the male reproductive system, possibly resulting in infertility. Myrrh is a resin with antioxidant properties that is produced from the bark of Commiphora tree species. This research aimed to observe the protective impact of myrrh extract supplementation on male reproductive injury and toxicity induced by ethanol treatment. Methods: Adult male Sprague Dawley rats were orally treated with 40% ethanol (3 g/kg) in combination with myrrh extract (500 mg/kg) for four weeks to investigate the curative efficiency of myrrh extract against ethanol toxicity from physiological, histopathological and genetic aspects. Result: The findings revealed that the sperm count, testosterone level and DNA concentration diminished significantly in the ethanol-treated rats compared to control rats, while the contents of malondialdehyde (MDA), heat shock protein 70 (HSP70) and proinflammatory mediators, including tumor necrosis factor-α (TNF-α) and nitric oxide (NO), were elevated significantly; severe degenerative changes in the testicular structure and strong testicular DNA fragmentation were also observed. Co-treatment with myrrh attenuated lipid peroxidation and improved testicular histomorphology, testosterone levels and DNA concentrations and pattern, while at the same time, the levels of both HSP70 and TNF-α levels were increased. Our results provide insight into the curative impacts of myrrh on ethanol toxicity resulting from the rich content of curzerene in myrrh, which has antioxidant activities.

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Section: Myrrh Attenuates Gonadal Toxicity and Dna Fragmentation Indu...supporting

confidence: 91%

Myrrh Attenuates Gonadal Toxicity and DNA Fragmentation Induced by Ethanol in Male Rats

Alahmari

2023

IJAR

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“…Synthetic drugs have often failed this goal, if not for a lack of efficacy, because of the greater risk to which the patient was exposed (acute and chronic toxicity and environmental hazard potential), leading the researchers to better explore natural remedies [1]. From this point of view, the study of essential oils has undergone a remarkable growth, and many new plants producing essential oil have been evaluated [16,17,18,19,20]. Among these, the authors decided to put their attention on Pistacia vera L., a nut tree that belongs to the Anacardiaceae family [21] cultivated in Iran, Turkey, the USA, Syria, Italy, Tunisia, and Greece.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Evaluation of the Antioxidant, Cytoprotective, and Antimicrobial Properties of Essential Oil from Pistacia vera L. Variety Bronte Hull

Smeriglio

Denaro

Barreca

et al. 2017

IJMS

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Although the chemical composition and biological properties of some species of the genus Pistacia has been investigated, studies on hull essential oil of Pistacia vera L. variety Bronte (HEO) are currently lacking. In this work, we have carried out an in-depth phytochemical profile elucidation by Gas Chromatography-Mass Spectrometry (GC-MS) analysis, and an evaluation of antioxidant scavenging properties of HEO, using several different in vitro methods, checking also its cytoprotective potential on lymphocytes treated with tert-butyl hydroperoxide. Moreover, the antimicrobial activity against Gram-positive and Gram-negative strains, both American Type Culture Collection (ATCC) and clinical isolates, was also investigated. GC-MS analysis highlighted the richness of this complex matrix, with the identification of 40 derivatives. The major components identified were 4-Carene (31.743%), α-Pinene (23.584%), d-Limonene (8.002%), and 3-Carene (7.731%). The HEO showed a strong iron chelating activity and was found to be markedly active against hydroxyl radical, while scarce effects were found against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. Moreover, pre-treatment with HEO was observed to significantly increase the cell viability, decreasing the lactate dehydrogenase (LDH) release. HEO was bactericidal against all the tested strains at the concentration of 7.11 mg/mL, with the exception of Pseudomonas aeruginosa ATCC 9027. The obtained results demonstrate the strong free-radical scavenging activity of HEO along with remarkable cytoprotective and antimicrobial properties.

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“…Studies have shown that curzerene treatment can reduce the secretion of tumor necrosis factor in THP‐1 cells, suggesting that it has potential as an anti‐inflammatory therapy 8 . In addition, low concentrations of curzerene may inhibit the release of nitric oxide from macrophages and then affect the activation of cell signaling 8,19 . Most recently, curzerene has been shown to inhibit the progression of non‐small‐cell lung cancer 8 .…”

Section: Discussionmentioning

confidence: 99%

“… 8 In addition, low concentrations of curzerene may inhibit the release of nitric oxide from macrophages and then affect the activation of cell signaling. 8 , 19 Most recently, curzerene has been shown to inhibit the progression of non‐small‐cell lung cancer. 8 These multiple positive results suggest that curzerene is a safe and effective therapeutic agent, which makes its potential application to a disease as deadly as glioma very interesting.…”

Section: Discussionmentioning

confidence: 99%

Curzerene suppresses progression of human glioblastoma through inhibition of glutathione S‐transferase A4

et al. 2022

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Glioma is the most common cancer of the human central nervous system, and it is also the most lethal tumor type. 1 According to data from the International Agency for Research on Cancer (IARC) regarding the global cancer burden, tumors of the central nervous system, including gliomas, caused approximately 30,000 deaths in China in 2020, making glioma the eighth most lethal tumor type in China. Glioma tumors progress rapidly and readily migrate to the surrounding brain tissue, and they are highly insensitive to

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Vasorelaxant and cardiovascular properties of the essential oil of Pogostemon elsholtzioides

Cited by 21 publications

References 10 publications

Myrrh Attenuates Gonadal Toxicity and DNA Fragmentation Induced by Ethanol in Male Rats

Myrrh Attenuates Gonadal Toxicity and DNA Fragmentation Induced by Ethanol in Male Rats

In Vitro Evaluation of the Antioxidant, Cytoprotective, and Antimicrobial Properties of Essential Oil from Pistacia vera L. Variety Bronte Hull

Curzerene suppresses progression of human glioblastoma through inhibition of glutathione S‐transferase A4

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