Vasopressin improves survival in a pig model of hypothermic cardiopulmonary resuscitation

Schwarz, Birgit; Mair, Peter; Raedler, Claus; Deckert, D.; Wenzel, Volker; Lindner, Karl H.

doi:10.1097/00003246-200206000-00027

Cited by 33 publications

(20 citation statements)

References 10 publications

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“…44 The guidelines of the European Resuscitation Council recommend a modified approach to advanced life support, consisting of up to three defibrillations, with epinephrine withheld until the core temperature is higher than 30°C (86°F) and with the interval between doses doubled until the core temperature is higher than 35°C (95°F). 8 These recommendations conflict with the American Heart Association guidelines, which state, "It may be reasonable to consider administration of a vasopressor during cardiac arrest according to the standard ALS [advanced life support] algorithm concurrently with rewarming strategies."…”

Section: Modified V Er Sus S Ta Nda R D a Dva Nced L Ife Supp Or Tmentioning

confidence: 99%

Accidental Hypothermia

et al. 2012

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A ccidental hypothermia (i.e., an involuntary drop in core body temperature to <35°C [95°F]) is a condition associated with significant morbidity and mortality. 1-4 Each year, approximately 1500 patients in the United States have hypothermia noted on their death certificate; however, the incidence of primary and secondary hypothermia and the associated morbidity and mortality remain unknown. 5 In a single tertiary care center, 14 different rewarming methods were used to treat 84 cases of accidental hypothermia, 3 which reflects the uncertainties about treatment and the potential for complications. 3 Certain treatment approaches are available only in specialized centers, and clarification is needed regarding the choice between transporting a patient to a specialized center and providing treatment locally. Existing recommendations do not include recent developments in rewarming methods nor do they assist with decisions regarding transportation. 6-8 PR E SEN TAT IONWith cold exposure, the initial response of the body is to maintain a normal core temperature (approximately 37°C [99°F]) by means of active movement and involuntary shivering. Primary hypothermia occurs when heat production in an otherwise healthy person is overcome by the stress of excessive cold, especially when the energy stores of the body are depleted. Secondary hypothermia can occur in ill persons with a wide variety of medical conditions (Table 1), even in a warm environment. Death in patients with secondary hypothermia is often caused by the underlying condition rather than by hypothermia. In all types of hypothermia, consciousness, breathing, and circulation are initially intact but are impaired as the body cools. 10

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Section: Modified V Er Sus S Ta Nda R D a Dva Nced L Ife Supp Or Tmentioning

confidence: 99%

Accidental Hypothermia

et al. 2012

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“…Although the international CPR guidelines recommend no vasopressor drugs when body temperature is Ͻ30°C, we have shown in hypothermic animal models that vasopressors indeed make successful defibrillation more likely, especially when combined with rewarming (13). This has been shown in another case report of a near-drowning accident, when restoration of circulation was possible after administration of a combination of epinephrine and vasopressin at a core body temperature of 27.4°C (14).…”

Section: Discussionmentioning

confidence: 67%

Cardiopulmonary resuscitation of a near-drowned child with a combination of epinephrine and vasopressin

Lienhart

John

Wenzel

2005

Pediatric Critical Care Medicine

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“…Μετά από τρία λεπτά θωρακικών συ μπιέσεων, τα ζώα κατανεμήθηκαν τυχαία σε δυο ομά δες: στην πρώτη χορηγήθηκε βαζοπρεσίνη ενδοφλε βίως και στη δεύτερη φυσιολογικός ορός. Στην πρώτη ομάδα η στεφανιαία πίεση, η επανάκτηση αυτόματης κυκλοφορίας και η επιβίωση ήταν σημαντικά υψηλό τερες (Schwarz et al 2002).…”

Section: πειραματικες μεδετες φαρμακωνunclassified

Swine as an animal model of cardiopulmonary resuscitation

Lelovas

Marinou

Xanthos

et al. 2017

J Hellenic Vet Med Soc

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This paper reviews the advantages of swine in relation to other animal models of cardiopulmonary resuscitation referred to in the literature. The causes of cardiac arrest and the difficulties raised during research in humans are presented. All animal models used in this particular field are discussed and a detailed review is performed regarding the major anatomical and physiological similarities between swine and man, as well as the experimental studies published in the international literature.

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Vasopressin improves survival in a pig model of hypothermic cardiopulmonary resuscitation

Abstract: A single 0.4-unit/kg dose of vasopressin administered at a body core temperature <30 degrees C significantly improved defibrillation success and 1-hr survival in a pig model of hypothermic cardiopulmonary resuscitation.

Cited by 33 publications

References 10 publications

Accidental Hypothermia

Accidental Hypothermia

Cardiopulmonary resuscitation of a near-drowned child with a combination of epinephrine and vasopressin

Swine as an animal model of cardiopulmonary resuscitation

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