Vasomotor symptoms in women and cardiovascular risk markers: Systematic review and meta-analysis

Franco, Oscar H.; Muka, Taulant; Colpani, Verônica; Kunutsor, Setor K; Chowdhury, Susmita; Chowdhury, Rajiv; Kavousi, Maryam

doi:10.1016/j.maturitas.2015.04.016

Cited by 73 publications

(45 citation statements)

References 57 publications

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“…Notably, these premenstrual symptoms are similar to vasomotor, cognitive, and psychological symptoms commonly experienced during the menopausal transition, many of which have also been associated with risk of hypertension and CVD. [39][40][41][42] A small number of studies have observed correlations between premenstrual symptoms and menopausal symptoms, [43][44][45][46][47] suggesting that women experiencing PMS in their younger reproductive years may be more likely to experience similar symptoms during the menopausal transition. Prospective studies assessing PMS in young women and following them through menopause and midlife are needed to address whether these conditions likely share an underlying etiology, and whether premenstrual vasomotor, cognitive, and physical symptoms may be related to future CVD risk through shared mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Association of Premenstrual Syndrome with Blood Pressure in Young Adult Women

Bertone‐Johnson

Houghton

Whitcomb

et al. 2016

Journal of Women's Health

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Objective: The prevalence of hypertension in premenopausal women is increasing. There is substantial need for novel strategies to identify women who would benefit from increased screening and early interventions. Several mechanisms likely contributing to premenstrual syndrome (PMS) are also involved in hypertension, including renin-angiotensin-aldosterone system dysfunction and micronutrient deficiencies. However, it is unknown whether young women with PMS have elevated blood pressure. Materials and Methods: We evaluated the association of blood pressure, PMS, and premenstrual symptoms in a cross-sectional study of 409 young women (mean age 21 years), conducted from 2006 to 2014. Our analysis included 78 cases (19%) who met established criteria for clinically significant PMS and 88 controls (22%) experiencing few symptoms. Blood pressure was measured during the mid-luteal phase. Lifestyle, diet, anthropometry, and other factors were measured by questionnaire and/or direct measurement. Results: After adjustment for smoking, body mass index, and other factors, mean diastolic blood pressure in PMS cases was 72.3 versus 69.1 mm Hg in controls ( p = 0.02). Diastolic blood pressure was also significantly higher in women reporting specific symptoms; for example, mean diastolic blood pressure in women reporting moderate or severe premenstrual nausea was 77.7 mm Hg compared with 71.0 mm Hg in women without nausea ( p = 0.007). Systolic blood pressure did not vary by PMS status. Conclusions: To our knowledge, this is among the first studies to suggest that diastolic blood pressure is elevated in young adult women experiencing PMS. Prospective studies are needed to determine whether PMS may be a useful sentinel for future hypertension risk in young women.

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Section: Discussionmentioning

confidence: 99%

Association of Premenstrual Syndrome with Blood Pressure in Young Adult Women

Bertone‐Johnson

Houghton

Whitcomb

et al. 2016

Journal of Women's Health

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“…For diastolic blood pressure, only night sweats were associated with a higher mean (mean difference 0.55 mmHg (95% CI, 0.19-0.91), when compared with women with no symptoms. Hot flushes per se did not confer an increased odds for hypertension, but night sweats were associated with a higher odds of hypertension compared to those without (OR 1.17, 95% CI: 1.04-1.31, one study) [16].…”

Section: Vasomotor Symptoms and Blood Pressurementioning

confidence: 86%

“…According to a recent systematic review with pooled analysis (12 studies, 19 667 women) published in this Journal [16] in 2015, systolic blood pressure tended to be higher in women with hot flushes (mean difference 1.95 mmHg, 95% CI 0.27-3.63) or night sweats (mean difference 1.33 mmHg, 95% CI, 0.63-2.03). For diastolic blood pressure, only night sweats were associated with a higher mean (mean difference 0.55 mmHg (95% CI, 0.19-0.91), when compared with women with no symptoms.…”

Section: Vasomotor Symptoms and Blood Pressurementioning

confidence: 99%

Vasomotor symptoms and metabolic syndrome

Tuomikoski

Savolainen-Peltonen

2017

Maturitas

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a b s t r a c tA vast majority of menopausal women suffer from vasomotor symptoms, such as hot flushes and night sweats, the mean duration of which may be up to 7-10 years. In addition to a decreased quality of life, vasomotor symptoms may have an impact on overall health. Vasomotor symptoms are associated with overactivity of the sympathetic nervous system, and sympathetic overdrive in turn is associated with metabolic syndrome, which is a known risk factor for cardiovascular disease. Menopausal hot flushes have a complex relationship to different features of the metabolic syndrome and not all data point towards an association between vasomotor symptoms and metabolic syndrome. Thus, it is still unclear whether vasomotor symptoms are an independent risk factor for metabolic syndrome. Research in this area is constantly evolving and we present here the most recent data on the possible association between menopausal vasomotor symptoms and the metabolic syndrome.

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“…The formation of atherosclerotic plaques increases the risk of ischemic heart disease (IHD) and stroke (106). Recent research indicates that vasomotor symptoms may represent an independent risk factor of cardiovascular disease (107).…”

Section: Mht and Ischemic Heart Diseasementioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview

Diamanti-Kandarakis

Dattilo²,

Macut

et al. 2017

European Journal of Endocrinology

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Aging and its underlying pathophysiological background has always attracted the attention of the scientific society. Defined as the gradual, time-dependent, heterogeneous decline of physiological functions, aging is orchestrated by a plethora of molecular mechanisms, which vividly interact to alter body homeostasis. The ability of an organism to adjust to these alterations, in conjunction with the dynamic effect of various environmental stimuli across lifespan, promotes longevity, frailty or disease. Endocrine function undergoes major changes during aging, as well. Specifically, alterations in hormonal networks and concomitant hormonal deficits/excess, augmented by poor sensitivity of tissues to their action, take place. As hypothalamic-pituitary unit is the central regulator of crucial body functions, these alterations can be translated in significant clinical sequelae that can impair the quality of life and promote frailty and disease. Delineating the hormonal signaling alterations that occur across lifespan and exploring possible remedial interventions could possibly help us improve the quality of life of the elderly and promote longevity.

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Vasomotor symptoms in women and cardiovascular risk markers: Systematic review and meta-analysis

Cited by 73 publications

References 57 publications

Association of Premenstrual Syndrome with Blood Pressure in Young Adult Women

Association of Premenstrual Syndrome with Blood Pressure in Young Adult Women

Vasomotor symptoms and metabolic syndrome

MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview

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