Vasomotor symptoms and metabolic syndrome

Tuomikoski, Pauliina; Savolainen-Peltonen, Hanna

doi:10.1016/j.maturitas.2016.12.010

Cited by 35 publications

(25 citation statements)

References 52 publications

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“…Elevated plasma leptin levels may drive sympathetic activation and dampen insulin sensitivity in obesity (Seravalle & Grassi, 2016). Other components of cardiorenal metabolic syndrome may also contribute to increased sympathetic tone as evidenced by sympathetic activation with hypertension (Seravalle & Grassi, 2016; Tuomikoski & Savolainen-Peltonen, 2017). Not surprisingly, heightened sympathetic tone is responsible for a number of unfavorable cardiorenal metabolic responses (Mahu & Domingos, 2017; Seravalle & Grassi, 2016; Tuomikoski & Savolainen-Peltonen, 2017).…”

Section: Pathophysiology Of the Cardiorenal Metabolic Syndromementioning

confidence: 99%

Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management

Zhang

Whaley‐Connell

Sowers

et al. 2018

Pharmacology & Therapeutics

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Although advances in medical technology and health care have improved the early diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity, insulin resistance, diabetes, hypertension, dyslipidemia, and kidney disease remains high. Findings from numerous population-based studies, clinical trials, and experimental evidence have consolidated a number of theories for the pathogenesis of cardiorenal metabolic anomalies including resistance to the metabolic action of insulin, abnormal glucose and lipid metabolism, oxidative and nitrosative stress, endoplasmic reticulum (ER) stress, apoptosis, mitochondrial damage, and inflammation. Accumulating evidence has recently suggested a pivotal role for proteotoxicity, the unfavorable effects of poor protein quality control, in the pathophysiology of metabolic dysregulation and related cardiovascular complications. The ubiquitin-proteasome system (UPS) and autophagy-lysosomal pathways, two major although distinct cellular clearance machineries, govern protein quality control by degradation and clearance of long-lived or damaged proteins and organelles. Ample evidence has depicted an important role for protein quality control, particularly autophagy, in the maintenance of metabolic homeostasis. To this end, autophagy offers promising targets for novel strategies to prevent and treat cardiorenal metabolic diseases. Targeting autophagy using pharmacological or natural agents exhibits exciting new strategies for the growing problem of cardiorenal metabolic disorders.

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Section: Pathophysiology Of the Cardiorenal Metabolic Syndromementioning

confidence: 99%

Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management

Zhang

Whaley‐Connell

Sowers

et al. 2018

Pharmacology & Therapeutics

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“…Adiponectin influences, among others, on the levels of interleukin 6 (proinflammatory cytokine), tumor necrosis factor-alpha (regulator of insulin resistance), leptin (regulator of energy balance and suppressor of food intake), and angiotensinogen PAI-1 (regulator of blood pressure and fluid balance) [175]. It was demonstrated that altered concentration of adiponectin changes the glucose homeostasis, the insulin resistance, and the enhanced inflammatory processes [176, 177]. Therefore, maintaining the stable level of adiponectin is important in the prevention of metabolic disorders like obesity [178], diabetes type 2 [179], hypertension, and cardiovascular diseases [180, 181].…”

Section: Training-evoked Increase In the Bdnf Level Prevents Symptmentioning

confidence: 99%

Health Benefits of Endurance Training: Implications of the Brain-Derived Neurotrophic Factor—A Systematic Review

Mrówczyński¹

2019

Neural Plasticity

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This article presents a concept that wide expression of brain-derived neurotrophic factor (BDNF) and its receptors (TrkB) in the nervous tissue, evoked by regular endurance training (ET), can cause numerous motor and metabolic adaptations, which are beneficial for human health. The relationships between the training-evoked increase of endogenous BDNF and molecular and/or physiological adaptations in the nervous structures controlling both motor performance and homeostasis of the whole organism have been presented. Due to a very wide range of plastic changes that ET has exerted on various systems of the body, the improvement of motor skills and counteraction of the development of civilization diseases resulting from the posttraining increase of BDNF/TrkB levels have been discussed, as important for people, who undertake ET. Thus, this report presents the influence of endurance exercises on the (1) transformation of motoneuron properties, which are a final element of the motor pathways, (2) reduction of motor deficits evoked by Parkinson disease, and (3) prevention of the metabolic syndrome (MetS). This review suggests that the increase of posttraining levels of BDNF and its TrkB receptors causes simultaneous changes in the activity of the spinal cord, the substantia nigra, and the hypothalamic nuclei neurons, which are responsible for the alteration of the functional properties of motoneurons innervating the skeletal muscles, for the enhancement of dopamine release in the brain, and for the modulation of hormone levels involved in regulating the metabolic processes, responsively. Finally, training-evoked increase of the BDNF/TrkB leads to a change in a manner of regulation of skeletal muscles, causes a reduction of motor deficits observed in the Parkinson disease, and lowers weight, glucose level, and blood pressure, which accompany the MetS. Therefore, BDNF seems to be the molecular factor of pleiotropic activity, important in the modulation processes, underlying adaptations, which result from ET.

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“…Helena Proni Fonseca Saú 1 Ana Carolina Basso Schmitt 2 Maria Regina Alves Cardoso 3 José Mendes Aldrighi 4…”

Section: Prevalence Of Hot Flashes In Women Of 40 To 65 Years Of Age mentioning

confidence: 99%

Prevalence of hot flashes in women of 40 to 65 years of age with metabolic syndrome

Saú

Schmitt

Cardoso

et al. 2020

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: Hot flashes have a negative impact on the quality of life of women during the menopausal transition and thereafter. The progressive reduction in gonadal estrogen levels associated with aging promotes an accumulation of abdominal fat, dyslipidemia, and arterial hypertension, all of which are components of metabolic syndrome (MetS). The objective of the present study was to estimate the prevalence of hot flashes and evaluate their relationship with MetS in women ≥ 40 years of age. METHODS: This was a cross-sectional study involving women aged between 40 and 65 years. We used the Kupperman index to quantify the climacteric symptoms and the National Cholesterol Education Program Adult Treatment Panel III criteria for the diagnosis of MetS. RESULTS: 1,435 women were initially selected, and we obtained information from 647. The mean age at menopause was 45.99 years (SD 6.61 years) and the prevalence of hot flashes and MetS were 55.83% (95% CI: 52.35-59.25%) and 46.29% (95% CI: 44.75-52.53%), respectively. We identified a positive association between MetS and hot flashes (OR 1.16; 95% CI: 1.01-1.33). CONCLUSIONS: In women ≥ 40 years of age, hot flashes are highly prevalent and appear to be associated with MetS.

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Vasomotor symptoms and metabolic syndrome

Cited by 35 publications

References 52 publications

Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management

Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management

Health Benefits of Endurance Training: Implications of the Brain-Derived Neurotrophic Factor—A Systematic Review

Prevalence of hot flashes in women of 40 to 65 years of age with metabolic syndrome

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