Vasodilator Effect of Olive Leaf

Abstract

We studied the importance of the smooth vascular muscle endothelium in the vasodilator action of the decoction of olive (Olea europaea) leaf. The decoction caused relaxation of isolated rat aorta preparations both in the presence (IC50 1.12 +/- 0.33 mg/ml) and in the absence (IC50 1.67 +/- 0.16 mg/ml) of endothelium. The results indicate that the relaxant activity of the lyophilized decoction is independent of the integrity of the vascular endothelium. We also showed that oleuropeoside is a component responsible for vasodilator activity but, from the results, it seems likely that at least one other principle is to be found in the olive leaf which is either a vasodilator itself or else potentiates the relaxant effect of oleuropeoside.

Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships

“…dissected and placed in a physiological saline solution (PSS) of the following composition (mM): NaC1 118, KCI 4.75, NaHCO 3 25, MgSO 4 1.2, CaCI 2 1.8, KH2PO 4 1.2 and glucose 11. After excess of fat and connective tissue was removed, the aortae were cut into helical strips (0.3 × 2 cm), mounted vertically under the basal tension of 1 g in 20 ml organ baths containing PSS and attached to forcedisplacement transducers (Letigraph 2000, Letica) to measure isometric contractile force as previously described (Zarzuelo et al, 1991;P~rez-Vizcaino et al, 1991). The tissue bath was maintained at 37°C and bubbled with 95% 02-5% CO2 gas mixture.…”

Oleuropein using as an Additive for Feed and Products used for Humans

“…Oleuropeoside also may exert vasodilator activity. Additionally, olive leaf extracts may possess antispasmodic, vasodilator, and anti-arrhythmic properties [41].…”

Antioxidant activity and phenolic contents of Olea europaea L. leaves sprayed with different copper formulations

“…They were formerly used as a folk remedy for combatting fevers and other diseases, such as malaria, but this use was dropped (PDR, 1998). Several reports have shown that olive leaf extract has the capacity to lower blood pressure in animals (Samuelsson, 1951) and increase blood flow in the coronary arteries (Zarzuelo, 1991), relieve arrhythmia and prevent intestinal muscle spasms (Garcia, Castillo, Lorente, Ortuno, & Del-Rio, 2000).…”