Vasoconstrictor and Dilator Actions of Nicotine and Electrical Transmural Stimulation on Isolated Dog Cerebral Arteries

Muramatsu, Ikunobu; Fujiwara, Motohatsu; Osumi, Yoshitsugu; Shibata, Shoji

doi:10.1159/000158157

Cited by 14 publications

(12 citation statements)

References 12 publications

(17 reference statements)

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“…The variable efficacy of TTX on the vascular response to nicotine is puzzling. The action of nicotine is abolished (Bell, 1968a) or partially attenuated in the rabbit ear artery (Furchgott et al, 1975) by TTX, but it is not influenced in the rabbit pulmonary artery (Su and Bevan, 1970), rabbit aorta (Ikushima et al, 1981), and dog basilar artery (Muramatsu et al, 1978) by TTX. In dog mesenteric, renal, and femoral arterial strips, nicotine-induced contractions mediated by norepinephrine are partially inhibited by TTX in concentrations (1-3 ϫ 10 Ϫ7 M) sufficient to abolish the contraction induced by electrical nerve stimulation (Toda et al, 1976).…”

Section: Nerve Stimulation By Electrical Pulses and Bymentioning

confidence: 99%

The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels

2003

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Section: Nerve Stimulation By Electrical Pulses and Bymentioning

confidence: 99%

The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels

2003

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“…For example, in the dog basilar artery, transmural electrical stimulation produces both contraction and relaxation which are resistant to al-and a2-adrenoceptor blocking agents (Muramatsu et al, 1981;Muramatsu & Kigoshi, 1987). There are also marked differences in the sensitivity of cerebral and peripheral arteries to various vasoconstrictor agents (Nielsen & Owman, 1971;Muramatsu et at., 1978). In general, noradrenaline and other a-adrenoceptor agonists cause only a modest contraction of cerebral 1 Author for correspondence.…”

Section: Introductionmentioning

confidence: 99%

Heterogeneity of neurogenic responses in intra‐ and extrameningeal arteries of dogs

Kohno¹,

Saito²,

Saitô³

et al. 1995

British J Pharmacology

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1 Neurogenic responses to transmural electrical stimulation were examined in endothelium-denuded extrameningeal (vertebral and carotid) and intrameningeal (spinal, basilar and middle cerebral) arteries isolated from dogs. 2 In the extrameningeal arteries, transmural electrical stimulation produced a phasic contraction. This contraction was abolished by tetrodotoxin, prazosin and guanethidine. However, a,fi-methylene ATP and N0-nitro-L-arginine (L-NOARG) had no significant effect on the contractile responses. 3 In the intrameningeal arteries, the neurogenic responses to electrical stimulation were composed of a transient contraction and relaxation. The transient contraction was selectively inhibited by guanethidine or after desensitization of P2x-purinoceptors with a,fi-methylene ATP. L-NOARG abolished the relaxation but not the contraction induced by electrical stimulation. Prazosin had no effect on either neurogenic response. 4 Noradrenaline produced a large contraction in the extrameningeal arteries which was selectively inhibited by prazosin. a,fl-Methylene ATP produced neither contraction nor inhibition of the response to noradrenaline in the extrameningeal arteries.5 In the intrameningeal arteries, a,fl-methylene ATP produced a greater contraction than noradrenaline. The response to a,#-methylene ATP was selectively abolished by desensitization of P2X-purinoceptors with a,f,-methylene ATP itself. The contractile response to noradrenaline was inhibited by rauwolscine but not by prazosin. 6 ATP produced endothelium-dependent relaxations in the extrameningeal and intrameningeal arteries, which were attenuated by endothelium removal. 7 NADPH diaphorase-positive fibres were dense in the middle cerebral and basilar arteries but rare or absent in the spinal artery. In the extrameningeal arteries diaphorase-positive traces were observed in the vasa vasorum.8 The present findings indicate that the neurogenic responses of intrameningeal arteries of dogs are composed of NO-ergic and sympathetic purinergic components, while the extrameningeal arteries tested produced only sympathetic adrenergic responses, suggesting that regional heterogeneity may be associated with a sudden transition in innervation and receptor expression at the meninx.

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“…Nielsen, 1974;Lee, Su & Bevan, 1976;Lee, Hume, In vitro experiments showed that in the cerebral Su & Bevan, 1978;Muramatsu, Fujiwara, Osumi & blood vessels, exogenously applied sympathomime- Shibata, 1978; Muramatsu, Fujiwara, Miura & tic substances do not, or only very weakly produce Sakakibara, 1981). However, the identity of the mechanical responses, as compared to their effects in chemical transmitter is not certain.…”

Section: Introductionmentioning

confidence: 99%

Membrane Properties and Excitatory Neuromuscular Transmission in the Smooth Muscle of Dog Cerebral Arteries

Fujiwara

Itoh

Suzuki

1982

British J Pharmacology

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1 Drug actions on electrical and mechanical properties of smooth muscle cells and neuromuscular transmission in the canine cerebral arteries were investigated by use of microelectrode and isometric tension recording methods. 2 In the basilar and middle cerebral arteries, the resting membrane potentials were -49.4 mV and -51.7 mV, respectively, the length constants 0.57mm and 0.45 mm, respectively and the time constants 142 ms and 118 ms, respectively. 3 Outward current pulses did not evoke the spike in either artery but did evoke the spike under conditions of pretreatment with 10mM tetraethylammonium (TEA). 4 The maximum slope of depolarization produced by a ten fold increase in [K]O plotted on a log scale was 40.1 mV in the basilar artery and 42.2 mV in the middle cerebral artery. 2-Nicotinamidoethyl nitrate, the K-permeability accelerator, had no effect on the membrane potential. 7 Perivascular nerve stimulation produced excitatory junction potentials (e.j.ps). Often e.j.ps were followed by a hyperpolarization. Repetitive stimulation produced facilitation after several stimuli and depression followed. In some cells, this depression appeared without facilitation.8 The e.j.ps ceased with pretreatment with guanethidine (10-6 M) or tetrodotox:n (3 x 10-7 M), while phentolamine (10-7 M) and yohimbine (10-7 M) enhanced the amplitude of e.j.ps. ATP (10-5 M) and noradrenaline (10-6 M) supressed and prazosin had little effect on the e.j.ps. Atropine (10-6 M) also had no effect on the e.j.ps. 9 Specific features of the cerebral artery and systemic vascular beds were compared, and the features of adrenoceptors on the smooth muscle membrane were compared with findings in other vascular beds.

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Vasoconstrictor and Dilator Actions of Nicotine and Electrical Transmural Stimulation on Isolated Dog Cerebral Arteries

Cited by 14 publications

References 12 publications

The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels

The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels

Heterogeneity of neurogenic responses in intra‐ and extrameningeal arteries of dogs

Membrane Properties and Excitatory Neuromuscular Transmission in the Smooth Muscle of Dog Cerebral Arteries

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