1992
DOI: 10.1017/s0965539500000589
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Vaso-active factors in pregnancy

Abstract: Pregnancy results in profound physiological changes in the cardiovascular system, yet these changes are completely reversible. It is apparent that vaso-active factors, some as yet probably unidentified, which act as humoral or local autocrine or paracrine regulators of vasular resistance, play a major role in these cardio-vascular changes. This role may be heightened in pregnancy when there has to be a large increase in blood flow to the uterus and placenta while maintaining adequate flow to other vascular bed… Show more

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Cited by 9 publications
(2 citation statements)
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“…The nature of the agent(s) remains speculative. Likely agents include the vasodilators prostacyclin and endothelium derived relaxing factors which are released in larger amounts in pregnancy (Friedman 1988;Ahokas et al 1991;Myatt 1992), and the reproductive hormones, oestrogens and progesterone (Rosenfeld & Jackson 1984;McLaughlin et al 1985;Naden & Rosenfeld 1985). Prostacyclin and endothelium derived relaxing factor (EDRF) have short lifespans and are known to function as paracrine agents rather than hormones (Friedman 1988;Pinto et al 1991).…”
Section: Discussionmentioning
confidence: 99%
“…The nature of the agent(s) remains speculative. Likely agents include the vasodilators prostacyclin and endothelium derived relaxing factors which are released in larger amounts in pregnancy (Friedman 1988;Ahokas et al 1991;Myatt 1992), and the reproductive hormones, oestrogens and progesterone (Rosenfeld & Jackson 1984;McLaughlin et al 1985;Naden & Rosenfeld 1985). Prostacyclin and endothelium derived relaxing factor (EDRF) have short lifespans and are known to function as paracrine agents rather than hormones (Friedman 1988;Pinto et al 1991).…”
Section: Discussionmentioning
confidence: 99%
“…Decreased dietary calcium may induce calcium depletion from all membrane storage sites, leading to instability of the vascular smooth muscle cell membrane 35 , which may trigger vasoconstriction and, possibly, elevated blood pressures and stroke. In addition to the possible direct action on smooth muscle cell contraction, calcium may also have indirect effects by modifying the responsiveness to or regulating the synthesis of vasoactive mediators, including angiotensin II and nitric oxide 36 . Kawasaki et al 37 discovered that vascular sensitivity to angiotensin II decreased evidently after the supplementation of calcium.…”
Section: Discussionmentioning
confidence: 99%