Dietary calcium, magnesium, and phosphorus intakes and risk of stroke in Chinese adults

Zhu, Hailu; Liu, Yan; Zhang, Jian; Wang, Mingxu; Jiang, Hong; Guo, Fang; Li, Ming; Qi, Fei-Fei; Liu, Xiaohong; Ma, Le

doi:10.1038/s41598-021-90388-z

Cited by 8 publications

(4 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Iran, an average intake of phosphate of 1200 mg/day was assessed, and, in another cohort, individuals reported between 180 and 1100 mg of phosphate intake per day [ 6 , 70 ]. Additionally, in a Chinese cohort, a phosphate intake between 700 and 1400 mg/day was assessed [ 114 ]. Taken together, these data and considering the reported underestimation, we can estimate than on average, an adult consumes around 1500 mg of phosphate per day.…”

Section: Dietary Phosphate Intakementioning

confidence: 99%

Phosphate intake, hyperphosphatemia, and kidney function

Rubio‐Aliaga

Krapf

2022

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

Phosphate is essential in living organisms and its blood levels are regulated by a complex network involving the kidneys, intestine, parathyroid glands, and the skeleton. The crosstalk between these organs is executed primarily by three hormones, calcitriol, parathyroid hormone, and fibroblast growth factor 23. Largely due to a higher intake of ultraprocessed foods, dietary phosphate intake has increased in the last decades. The average intake is now about twice the recommended dietary allowance. Studies investigating the side effect of chronic high dietary phosphate intake suffer from incomplete dietary phosphate assessment and, therefore, often make data interpretation difficult. Renal excretion is quickly adapted to acute and chronic phosphate intake. However, at the high ends of dietary intake, renal adaptation, even in pre-existing normal kidney function, apparently is not perfect. Experimental intervention studies suggest that chronic excess of dietary phosphate can result in sustained higher blood phosphate leading to hyperphosphatemia. Evidence exists that the price of the homeostatic response (phosphaturia in response to phosphate loading/hyperphosphatemia) is an increased risk for declining kidney function, partly due by intraluminal/tubular calcium phosphate particles that provoke renal inflammation. High dietary phosphate intake and hyperphosphatemia are progression factors for declining kidney function and are associated with higher cardiovascular disease and mortality risk. This is best established for pre-existing chronic kidney disease, but epidemiological and experimental data strongly suggest that this holds true for subjects with normal renal function as well. Here, we review the latest advances in phosphate intake and kidney function decline.

show abstract

Section: Dietary Phosphate Intakementioning

confidence: 99%

Phosphate intake, hyperphosphatemia, and kidney function

Rubio‐Aliaga

Krapf

2022

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

show abstract

“…Mg is suggested to act in a dose-dependent manner: for each 100 mg/day, the risk is reduced by 2% [65]. However, a recent study in 6411 interviewed participants (aged 45-79 years) free of stroke at baseline suggested that only dietary calcium intake, but not Mg, is associated with a lower risk of stroke in Chinese adults, particularly in men [103]. The observational nature of the studies and lack of RCTs is a limiting factor.…”

Section: Magnesium and Cardiovascular Functionmentioning

confidence: 99%

“…High Mg concentration has been shown in vitro to inhibit the mineralization process and to modulate gene expression of mesenchymal stem cells during osteogenic differentiation. Involvement of Mg transporter SLC41A1 [103] and of Mg substitution for calcium in the hydroxyapatite structure [152] has been suggested.…”

Section: Prospects Of Mg In the Cardiovascular Disease-sarcopenia-osteoporosis Triadmentioning

confidence: 99%

Cross-Talks between the Cardiovascular Disease-Sarcopenia-Osteoporosis Triad and Magnesium in Humans

Pickering¹

2021

IJMS

View full text Add to dashboard Cite

Magnesium (Mg) is a pivotal and very complex component of healthy aging in the cardiovascular-muscle-bone triad. Low Mg levels and low Mg intake are common in the general aging population and are associated with poorer outcomes than higher levels, including vascular calcification, endothelial dysfunction, osteoporosis, or muscle dysfunction/sarcopenia. While Mg supplementation appears to reverse these processes and benefit the triad, more randomized clinical trials are needed. These will allow improvement of preventive and curative strategies and propose guidelines regarding the pharmaceutical forms and the dosages and durations of treatment in order to optimize and adapt Mg prescription for healthy aging and for older vulnerable persons with comorbidities.

show abstract

“…Although previous studies [20][21][22][23][24][25][26][27][28][29][30][31][32] have evaluated the relationship between dietary magnesium intake and stroke risk, the results are controversial. A 12-year follow-up study showed that people with a high magnesium diet had a low risk for total stroke.…”

mentioning

confidence: 99%

Association of Dietary Magnesium Intake with the Risk of Stroke among Adults

Sun,

Wang,

et al. 2023

Int. Heart J.

View full text Add to dashboard Cite

The relationship between dietary magnesium intake and the risk of stroke is controversial. This study aimed to examine the association of dietary magnesium intake with the risk of stroke among American adults.The relationship between dietary magnesium intake and the risk of stroke was analyzed using the National Health and Nutrition Examination Survey (NHANES) 2007-2018 data with 29,653 adults. The amount of magnesium from the diet was assessed by two 24-hour dietary recalls. Stroke outcomes were defined using the results of the self-reported questionnaires. The association between dietary magnesium intake and the risk of stroke was evaluated using logistic regression models and restricted cubic spline.In our study, an inverse association between dietary magnesium intake and the risk of stroke was found. For the highest versus lowest quartile of dietary magnesium intake, the multivariate-adjusted odds ratio (95% confidence interval) of stroke was 0.56 (0.36-0.86). The magnesium intake of women was negatively associated with stroke risk, but this negative association was not found in men. Then, the inverse association was statistically significant among the 40-59 year-old group. The results from the dose-response analysis show a linear relationship between dietary magnesium intake and the risk of stroke.Dietary magnesium intake was inversely associated with the risk of stroke, especially in women. Therefore, our study emphasizes the importance of appropriately increasing dietary magnesium intake.

show abstract

Dietary calcium, magnesium, and phosphorus intakes and risk of stroke in Chinese adults

Cited by 8 publications

References 52 publications

Phosphate intake, hyperphosphatemia, and kidney function

Phosphate intake, hyperphosphatemia, and kidney function

Cross-Talks between the Cardiovascular Disease-Sarcopenia-Osteoporosis Triad and Magnesium in Humans

Association of Dietary Magnesium Intake with the Risk of Stroke among Adults

Contact Info

Product

Resources

About