Vaskulärer Ergotismus durch Getreidestaubinhalation

Stånge, K.; Pohlmeier, H.; Lübbesmeyer, A.; Gumbinger, G.; Schmitz, Wilhelm; Baumgart, Peter

doi:10.1055/s-2007-1024221

Cited by 20 publications

(8 citation statements)

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“…Several literature data suggest the formation of a toxin depot of ergot alkaloids and, consequently, an accumulation effect. ,− Binding of ergot alkaloids to cellular compartments cannot be excluded, inducing the described toxic effects. Taken the accumulation properties into account, even small concentrations could be enriched, having ultimately toxic properties.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity and Fluorescence Visualization of Ergot Alkaloids in Human Cell Lines

Mulac

Lepski

Ebert

et al. 2013

J. Agric. Food Chem.

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The ergot alkaloids as secondary metabolites from fungi of the genus Claviceps are the focus of many investigations because of their pharmacological and toxicological properties. The main effects of ergot alkaloids are referred to an interaction with several receptor systems in the human body. It is well-known that ergot alkaloids are able to isomerize with one isomer being biologically active and one being only weakly active, whereas the activity is restricted to receptor interactions. Latest investigations have proven that ergot alkaloids also show cytotoxic effects and induce apoptosis in human primary cells. These effects seem to correlate with accumulation properties. It was the aim of our current study to determine such effects in cancer cell lines, because ergot derivatives are also used in tumor therapy. Our results confirm the apoptotic effects in two cancer cell lines (HepG2 and HT-29) in a high range, and accumulation measurements show an interesting correlation between the alkaloid concentration in the cell lysate of the receptor-inactive isomers and cytotoxicity. In addition, the strong accumulative effects were first visualized by fluorescence microscopy by taking advantage of the natural fluorescence properties of ergot alkaloids.

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity and Fluorescence Visualization of Ergot Alkaloids in Human Cell Lines

Mulac

Lepski

Ebert

et al. 2013

J. Agric. Food Chem.

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“…For instance, while the respiratory administration of spores tended to result in an increased activity of alveolar macrophages and inflammatory reactions in pulmonary tissue (51), the administration of pure mycotoxins such as aflatoxin B 1 was found to inhibit the phagocytic activity of alveolar macrophages in the rat and in human monocytes (38; 52). From the results of case studies, it is known that exposure situations may occur in which acute health impairments can arise (42)(43)(44). Moreover, the epidemiological studies mentioned further above (20-23) must be viewed as an indication that potential health risks are indeed associated with the respiratory intake of mycotoxins at the workplace.…”

Section: Discussionmentioning

confidence: 99%

“…Adverse health effects after respiratory intake of mycotoxins have been described, inter alia, by Dvorackova, Di Paolo et al and Stange et al (42)(43)(44). In one case, acute disease was described as having been triggered by handling, over a three-month period, peanut meal contaminated with Aspergillus flavus in the development of sterilization methods (42).…”

Section: Intoxications/case Reportsmentioning

confidence: 99%

The significance of mycotoxins in the framework of assessing workplace related risks

et al. 2008

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Mycotoxins are fungal metabolite which may in some cases exhibit a high health hazard potential. Mycotoxins can show carcinogenic, mutagenic, toxic, teratogenic or immunotoxic effects. Mycotoxin exposure in the workplace may occur through inhalation and skin contact,e.g. during occupational handling of organic matter such as livestock feed, food products, or waste. Various studies suggest that both acute and chronic effects can occur, depending at least on the exposure level. The magnitude of the potential health risks associated with a respiratory or dermal intake of mycotoxins has largely remained unclear to date. However, according to the directive 2000/54/EC on biological agents and the corresponding German Biological Agents Ordinance, employers are also required to consider the potential hazards posed by toxic effects of biological agents when assessing workplace risks. The aim of this article, therefore, is to present some basis information that should facilitate an evaluation of the significance of mycotoxins in the context of assessing workplace risks. It also provides suggestions for occupational health and safety measures.

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“…While ergot alkaloid incidences are rare in humans resulting from increased regulation of grain processing (Flieger et al, 1997 ; EFSA, 2012 ), reports are still present from occasional pharmacological overdose or accidental exposure (e.g., Stange et al, 1998 ). More broad aspects of alkaloid-derived problems still persist in intensive and extensive livestock systems.…”

mentioning

confidence: 99%

Recent investigations of ergot alkaloids incorporated into plant and/or animal systems

Klotz

Smith

2015

Front. Chem.

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Vaskulärer Ergotismus durch Getreidestaubinhalation

Abstract: This is the first reported case proving that chronic ergotamine inhalation can cause ergotism affecting peripheral arteries. As the plasma ergotamine level fell only slowly it must be assumed that ergotamine had accumulated in a, so far unknown, body depot with slow release into the blood.

Cited by 20 publications

References 0 publications

Cytotoxicity and Fluorescence Visualization of Ergot Alkaloids in Human Cell Lines

Cytotoxicity and Fluorescence Visualization of Ergot Alkaloids in Human Cell Lines

The significance of mycotoxins in the framework of assessing workplace related risks

Recent investigations of ergot alkaloids incorporated into plant and/or animal systems

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