Vasculogenic mimicry and pseudo‐comedo formation in breast cancer

Shirakawa, Kazuo; Wakasugi, Hiro; Heike, Yuji; Watanabe, Ichirô; Yamada, Shigeki; Saito, Ken; Konishi, Fumio

doi:10.1002/ijc.10423

Cited by 153 publications

(135 citation statements)

References 22 publications

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“…All these variables are important prognostic factors of PCa. This observation is different from that of a previous study in reference 20, that reported that breast carcinomas engaged in VM had a higher rate of distant metastasis, but there was no significant correlation between VM and lymph node metastasis. Another study on laryngeal squamous cell carcinoma reported a significant correlation between VM and lymph node metastasis status, but failed to find a significant correlation with distant metastasis.…”

Section: Discussioncontrasting

confidence: 99%

Vasculogenic mimicry is a marker of poor prognosis in prostate cancer

Liu

Yang

Meng

et al. 2012

Cancer Biology & Therapy

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Section: Discussioncontrasting

confidence: 99%

Vasculogenic mimicry is a marker of poor prognosis in prostate cancer

Liu

Yang

Meng

et al. 2012

Cancer Biology & Therapy

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“…6,46 Human studies suggested that it furnishes an additional blood supply to the tumor and facilitates hematogenous dissemination. 12,37,46 In dogs this phenomenon was hypothesized to promote the lymphatic spread of tumor cells. 6 In the present study, we found vasculogenic mimicry almost exclusively in simple anaplastic carcinomas, which supports the theory that the formation of these channels is due to a lack of differentiation and marked plasticity of the tumor cells.…”

Section: Discussionmentioning

confidence: 99%

“…37,40 For CMCs, the histologic grade of malignancy is of prognostic significance, and many authors have suggested that it be routinely included in the pathology report. 21,26 There are several systems used to assign a histologic grade to CMCs; most are a modification of the method of Ellston and Ellis used for human breast cancers.…”

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confidence: 99%

A Retrospective Study of Those Histopathologic Parameters Predictive of Invasion of the Lymphatic System by Canine Mammary Carcinomas

et al. 2011

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The aim of the present study was to determine which histopathologic parameters of primary canine mammary carcinomas (CMCs) could predict metastatic spread via the lymphatic system. A modification of the World Health Organization classification was applied to 245 CMCs. In addition to tumor subtype, neoplastic infiltration of the surrounding mammary stroma, vasculogenic mimicry, and micropapillary pattern were evaluated, and 2 histologic grading systems were used for each sample. A statistical analysis was undertaken to determine the relationship between these histopathologic parameters and the detection of lymphatic vessels invasion (LVI) and regional lymph node metastases (RLM). To compare the predictive value for lymphatic spread of the 2 histologic grading systems, the Akaike information criterion was measured. The classification into tumor subtypes was significant (P < .01) in predicting the risk of LVI and RLM. Peripheral infiltration, vasculogenic mimicry, and micropapillary pattern were found in 170 of 245 (69.4%), 32 of 245 (13.1%), and 54 of 245 (22.0%) CMCs. The presence of peripheral infiltration was significantly associated (P < .001) with both LVI and RLM, and a similar relation (P < .05) was found for the micropapillary pattern. Vasculogenic mimicry was not predictive of invasion of the lymphatic system. Both histologic grading systems were significant predictors (P < .001) of the risk of LVI and RLM. The grading system that included a more rigorous evaluation of the neoplastic mitotic activity had the lower Akaike information criterion values, thus indicating a better predictive ability. The study confirms the significant prognostic role for the modified World Health Organization classification of CMCs and the prognostic value of additional histopathologic parameters.

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“…4,5 Vasculogenic mimicry is another form of vessel formation that has been reported in certain tumor types, such as aggressive human uveal melanomas, prostate and breast tumors. [6][7][8] In these cases, networks of tumor cell-lined vascular channels were identified within the tumors. Finally, vessel co-option, implemented by tumor cells as a temporary means of gaining access to a blood supply, involves the tumor cells growing around and thus co-opting existing host vessels to form an initially well-vascularized tumor.…”

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confidence: 99%

Metalloproteinases and their inhibitors in tumor angiogenesis

Handsley

Edwards

2005

Intl Journal of Cancer

260

211

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Angiogenesis is the process by which new blood vessels are formed from preexisting vasculature. It is an essential feature of the female reproductive cycle, embryonic development and wound repair. Angiogenesis has also been identified as a causal or contributing factor in several pathologies, including cancer, where it is a rate-limiting step during tumor progression. Matrix metalloproteinases (MMPs) are a family of soluble and membrane-anchored proteolytic enzymes that can degrade components of the extracellular matrix (ECM) as well as a growing number of modulators of cell function. Several of the MMPs, in particular the gelatinases and membrane-type 1 MMP (MT1-MMP), have been linked to angiogenesis. Potential roles for these proteases during the angiogenic process include degradation of the basement membrane and perivascular ECM components, unmasking of cryptic biologically relevant sites in ECM components, modulation of angiogenic factors and production of endogenous angiogenic inhibitors. This review brings together what is currently known about the functions of the MMPs and the closely related ADAM (a disintegrin and metalloproteinase domain) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) families in angiogenesis and considers how this information might be useful in manipulation of the angiogenic process, with a view to constraining tumor progression. ' 2005 Wiley-Liss, Inc.Key words: metalloproteinase; tumor; angiogenesis; tissue inhibitor of metalloproteinases; protease; extracellular matrix Angiogenesis is an essential feature of several physiologic processes such as the developmental growth of organs, wound healing and the female reproductive cycle. 1 It is also particularly significant in cancer progression, being a crucial step in the transition of a tumor from a hyperplastic but contained in situ state to a malignant phenotype. 2,3 To allow its growth beyond a certain critical size, a solid avascular tumor must develop its own blood supply in order to meet its growing metabolic requirements. 1 Vascularization of a tumor also provides a route for dissemination of the tumor cells to different sites around the body.Although angiogenesis appears to be the primary form of tumor vascularization, the malignant cells of a tumor can gain access to a blood supply through other means, such as via tumor-induced vasculogenesis, in which bone marrow-derived precursor endothelial cells contribute to the formation of tumor vessels. 4,5 Vasculogenic mimicry is another form of vessel formation that has been reported in certain tumor types, such as aggressive human uveal melanomas, prostate and breast tumors. [6][7][8] In these cases, networks of tumor cell-lined vascular channels were identified within the tumors. Finally, vessel co-option, implemented by tumor cells as a temporary means of gaining access to a blood supply, involves the tumor cells growing around and thus co-opting existing host vessels to form an initially well-vascularized tumor. 9 This review will highlight new insigh...

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Vasculogenic mimicry and pseudo‐comedo formation in breast cancer

Cited by 153 publications

References 22 publications

Vasculogenic mimicry is a marker of poor prognosis in prostate cancer

Vasculogenic mimicry is a marker of poor prognosis in prostate cancer

A Retrospective Study of Those Histopathologic Parameters Predictive of Invasion of the Lymphatic System by Canine Mammary Carcinomas

Metalloproteinases and their inhibitors in tumor angiogenesis

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