Vascular tumors of bone: a study of 17 cases other than ordinary hemangioma, with an evaluation of the relationship of hemangioendothelioma of bone to epithelioid hemangioma, epithelioid hemangioendothelioma, and high-grade angiosarcoma

Evans, Harry L.; Raymond, A. Kevin; Ayala, Alberto G.

doi:10.1016/s0046-8177(03)00249-1

Cited by 113 publications

(87 citation statements)

References 16 publications

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“…Angiosarcoma of bone is rare and accounts for less than 1% of primary skeletal malignancies, with very limited reports in the literature [32]. There can be two different patterns of presentation [18,32]. One pattern is a tumor presenting as multiple lesions in a single bone, or multiple lesions presenting in adjacent bones or even all the bones of a limb.…”

Section: Cutaneous Angiosarcoma Associated With Radiation or Lymphedemamentioning

confidence: 99%

Malignant tumors of blood vessels: Angiosarcomas, hemangioendotheliomas, and hemangioperictyomas

Koch

Nielsen

Yoon

2008

Journal of Surgical Oncology

100

107

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Sarcomas that arise from or resemble the components of blood vessels are uncommon and include angiosarcomas, hemangioendotheliomas, and hemangiopericytomas. This article reviews the management of these three types of sarcomas. Diagnosis can sometimes be difficult, with the diagnosis of hemangiopericytoma versus solitary fibrous tumor currently in debate. Each of these sarcomas subtypes has certain unique clinical traits. The mainstay of treatment is surgical resection, sometimes combined with radiation therapy. Adjuvant chemotherapy is unproven but can be considered. For patients with advanced disease, various chemotherapeutic regimens may result in meaningful responses in a minority of patients.

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Section: Cutaneous Angiosarcoma Associated With Radiation or Lymphedemamentioning

confidence: 99%

Malignant tumors of blood vessels: Angiosarcomas, hemangioendotheliomas, and hemangioperictyomas

Koch

Nielsen

Yoon

2008

Journal of Surgical Oncology

100

107

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“…Microscopically the most prominent characteristic of angiosarcomas, is their tendency for irregular vasoformation [1,[10][11][12][13][14][15][16]. The degree of cytological atypia is remarkable and prominent, while nuclear pleomorphism as well as numerous mitotic figures is predominant.…”

Section: Discussionmentioning

confidence: 99%

“…Areas of hemorrhage may be shown. Immunohistochemical staining for factor VIII (von Willebrand Factor), CD31 relative antigen and vimentin testify their endothelial origin [1,3,[10][11][12][13][14][15][16]. The endothelial cell specific markers CD 31and VIII are by far the most valuable to identify malignant vascular tumors and to exclude metastatic carcinoma, from the differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Metastatic lung angiosarcoma from a femoral subperiosteal origin

et al. 2011

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AbstractPrimary malignant vascular bone tumors are unusual and include hemangioendothelioma, epitheloid hemangioendothelioma and angiosarcoma. Although few cases of primary bone angiosarcomas have been reported, those of femoral origin are even more infrequent. Such tumors diagnosis may be challenging due to their radiographic and histologic variety. We present a case of a 24-yearold woman with a subperiosteal diaphyseal angiosarcoma originating from the femoral bone and metastatic to the lung at the time of diagnosis. The clinical, histological and radiological features of this extremely rare lesion are presented.

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“…Various mechanisms have been described, including metastatic spread, malignant transformation and multifocal formation. It is difficult to identify whether a multicentric disease is primarily multicentric or whether it is a result of metastases from a primary unicentric tumor (16,17). Visceral involvement was reported to be the most important criterion in predicting a poor prognosis.…”

Section: Case Reportmentioning

confidence: 99%

Bone multicentric epithelioid hemangioendothelioma of the lower and upper extremities with pulmonary metastases: A case report

Zhang

2015

Oncology Letters

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Abstract. The present study reports a rare case of bone multicentric epithelioid hemangioendothelioma (EH) involving the upper and lower extremities simultaneously, with visceral involvement of the lung. Osteolytic lesions were first identified in the right distal femur and proximal tibia. Slight increased radionuclide uptake was observed in the right shoulder joint on bone scintigraphy, however, this was ignored, as no clinical symptoms were present. The pa tient was initially misdiagnosed with multifocal chondroblastoma, and an extra-articular curettage of lesions was performed in the proximal tibia and medial femoral condyle, which was filled with bone cement. The histopathological diagnosis was corrected post-operatively following immunohistochemical analysis, which indicated EH, and subsequently, an amputation of the right leg at thigh level was performed. In addition, multiple lytic lesions in the right shoulder joint and pulmonary metastases were identified on whole-body radiological examination. Radiotherapy was administered to the right shoulder joint, however, the patient re fused chemotherapy or further surgery. At 15 months after the initial surgery, the patient currently remains alive. This case indicates that an improved understanding with regard to the clinical features of this disease may prevent misdiagnosis and improve EH treatment.

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Vascular tumors of bone: a study of 17 cases other than ordinary hemangioma, with an evaluation of the relationship of hemangioendothelioma of bone to epithelioid hemangioma, epithelioid hemangioendothelioma, and high-grade angiosarcoma

Cited by 113 publications

References 16 publications

Malignant tumors of blood vessels: Angiosarcomas, hemangioendotheliomas, and hemangioperictyomas

Malignant tumors of blood vessels: Angiosarcomas, hemangioendotheliomas, and hemangioperictyomas

Metastatic lung angiosarcoma from a femoral subperiosteal origin

Bone multicentric epithelioid hemangioendothelioma of the lower and upper extremities with pulmonary metastases: A case report

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