Vascular tissue engineering from human adipose tissue: fundamental phenotype of its resident microvascular endothelial cells and stromal/stem cells

Antonyshyn, Jeremy A.; McFadden, Meghan J.; Gramolini, Anthony O.; Höfer, Stefan; Santerre, J. Paul

doi:10.1016/j.bbiosy.2022.100049

Cited by 2 publications

(3 citation statements)

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“…Their findings indicate that ADSCs may contribute to the stabilization and maturation of the endothelium, partly by aiding in the assembly of its basement membrane [6].…”

Section: Endothelial Cells Differentiationmentioning

confidence: 99%

“…The observation that adipose-derived ECs exhibit enhanced proliferation under poor conditions compared to dermal-derived ECs suggests a potential for superior proliferation when used in wound treatment under poor conditions [107]. Despite the naturally differentiated ECs, considerable attention is devoted to generating ECs from resident stem and progenitor cells in AT [6]. The differentiation capacity of ADSCs into ECs was initially demonstrated in 2004.…”

Section: Endothelial Cells Differentiationmentioning

confidence: 99%

“…In the past three decades, TE and regenerative medicine have had a remarkable impact on in vivo and ex vivo research and innovation, driven by the quest for effective solutions to address various challenges in diagnosing and replacing diseased and injured tissues [1][2][3][4][5][6]. As the integration of cells into engineered tissues is crucial for achieving proper structure and function, cell-based therapies play an essential role in tissue formation and have notably evolved as innovative and routine clinical solutions worldwide.…”

Section: Introductionmentioning

confidence: 99%

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Adipose-Derived Stem Cells: Angiogenetic Potential and Utility in Tissue Engineering

Biniazan,

Stoian,

Haykal

2024

IJMS

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Adipose tissue (AT) is a large and important energy storage organ as well as an endocrine organ with a critical role in many processes. Additionally, AT is an enormous and easily accessible source of multipotent cell types used in our day for all types of tissue regeneration. The ability of adipose-derived stem cells (ADSCs) to differentiate into other types of cells, such as endothelial cells (ECs), vascular smooth muscle cells, or cardiomyocytes, is used in tissue engineering in order to promote/stimulate the process of angiogenesis. Being a key for future successful clinical applications, functional vascular networks in engineered tissue are targeted by numerous in vivo and ex vivo studies. The article reviews the angiogenic potential of ADSCs and explores their capacity in the field of tissue engineering (TE).

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“…Their findings indicate that ADSCs may contribute to the stabilization and maturation of the endothelium, partly by aiding in the assembly of its basement membrane [6].…”

Section: Endothelial Cells Differentiationmentioning

confidence: 99%

Section: Endothelial Cells Differentiationmentioning

confidence: 99%