Vascular Risk Factors, Endothelial Function, and Carotid Thickness in Patients with Migraine: Relationship to Atherosclerosis

Hamed, Sherifa A.; Hamed, Enas A.; Eldin, Azza M. Ezz; Mahmoud, Nagia M.

doi:10.1016/j.jstrokecerebrovasdis.2009.04.007

Cited by 111 publications

(144 citation statements)

References 40 publications

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“…27 Second, smoking is a known risk factor for atherosclerosis; although increased arterial stiffness, carotid intima-media thickness, and impaired endothelial-dependent vasoreactivity have been associated with migraine, an increased association between atherosclerosis and migraine is not evident. 28,29 Finally, prothrombotic states, decreased platelet hemostasis time, and endothelial dysfunction associated with migraine are all plausible mechanisms for which stroke risk may be enhanced in active smokers. 30 Taken together, we suspect that a synergic action may occur between vascular changes of migraine and smoking as an effect modifier although further work is necessary to elucidate this association.…”

Section: Resultsmentioning

confidence: 99%

Migraine and risk of stroke in older adults

et al. 2015

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Objective: To examine the association between migraine and stroke/vascular outcomes in a racially/ethnically diverse, older cohort.Methods: Participants from the Northern Manhattan Study, a population-based cohort study of stroke incidence, were assessed for migraine symptoms using a self-report questionnaire based on criteria from the International Classification of Headache Disorders, second edition. We estimated the association between migraine and combined vascular events including stroke and stroke only over a mean follow-up of 11 years, using Cox models adjusted for sociodemographic and vascular risk factors.Results: Of 1,292 participants (mean age 68 6 9 years) with migraine data followed prospectively for vascular events, 262 patients (20%) had migraine and 75 (6%) had migraine with aura. No association was found between migraine (with or without aura) and risk of either stroke or combined cardiovascular events. There was an interaction between migraine and current smoking (p 5 0.02 in relation to stroke and p 5 0.03 for combined vascular events), such that those with migraine and smoking were at an increased risk. The hazard ratio of stroke for migraine among current smokers was 3.17 (95% confidence interval [CI] 1.13-8.85) and among current nonsmokers was 0.77 (95% CI 0.44-1.35). In relation to combined vascular events, the hazard ratio for migraine vs no migraine among current smokers was 1.83 (95% CI 0.89-3.75) and among current nonsmokers was 0.63 (95% CI 0.43-0.94). Conclusion:In our racially/ethnically diverse population-based cohort, migraine was associated with an increased risk of stroke among active smokers but not among nonsmokers. Migraine is a complex neurovascular syndrome resulting in an unstable trigeminal vascular system. It has been suggested that migraine and stroke exist on a continuum, and the vascular system may have important secondary consequences in migraine.1 While the vascular theory of migraine has been disproved, migraine with aura, mostly in women younger than 45 years, has been shown to be an independent risk factor for ischemic stroke.2 Some studies also suggest that migraine is associated with an unfavorable cardiovascular risk profile, cardiovascular disease events, and vascular death.3-8 However, there are no reliable indicators to predict which migraineurs will develop cerebrovascular ischemic insults and other vascular events. Moreover, migraine may be a potentially modifiable vascular risk factor, requiring further exploration in high-risk populations.The objective of this study was to assess the association between migraine, including both migraine with and without aura, and stroke in the Northern Manhattan Study (NOMAS), an ethnically diverse, older, community-based cohort. As a secondary aim, we also explored the association between migraine and vascular events/mortality.

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Section: Resultsmentioning

confidence: 99%

Migraine and risk of stroke in older adults

et al. 2015

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“…Careful reading of title, abstract and full text (when available), allowed to exclude 118 articles, which did not reported original data about the epidemiological association between CRP and migraine, or did not use standardized criteria for diagnosis of migraine. Therefore, 17 clinical studies were finally included in this review, i.e., one retrospective, one interventional, 14 cross-sectional and one both interventional and cross-sectional (Table 1) [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Demographical information, along with the techniques used for measuring CRP [i.e., conventional or highsensitivity (HS)], were reported, whenever available.…”

Section: Overview On Epidemiological Datamentioning

confidence: 99%

C-reactive protein and migraine. Facts or speculations?

Lippi¹,

Mattiuzzi²,

Cervellin

2014

Clinical Chemistry and Laboratory Medicine

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Migraine is a highly prevalent and frequently disabling disorder. Since the pathogenesis of this condition has a strong inflammatory component and migraine is significantly associated with cardiovascular disease, we assess whether C-reactive protein (CRP) may be epidemiologically or casually linked with migraine. An electronic search on Medline, Scopus and Web of Science produced 17 studies reporting original data about the epidemiological association between CRP and migraine (1 retrospective, 1 interventional, 14 cross-sectional and 1 both interventional and cross-sectional). When all studies reporting sufficient data about CRP values were pooled (n = 12; 6980 cases and 38,975 controls), the concentration of CRP was found to be significantly higher in patients with migraine than in controls (weighted mean difference 1.12 mg/L; 95% CI 1.01-1.25 mg/L; p < 0.001). In further analysis of studies containing separate data for migraine with and without aura (n = 7), CRP values remained significantly higher in both migraineur patients with aura (n = 1939; weighted mean difference 0.88 mg/L; 95% CI 0.63-1.14 mg/L; p < 0.001) or without aura (n = 2483; weighted mean difference 1.04 mg/L; 95% CI 0.78-1.30 mg/L; p < 0.001) when compared with controls (n = 29,354). Despite a large interstudy heterogeneity (99.3%), our analysis provides evidence of a potential epidemiological association between increased concentration of CRP and migraine, thus paving the way for further clinical investigations about therapeutic agents that may contextually decrease the risk of cardiovascular disease and reduce the burden of migraine.

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“…[21] Contrary to reports suggesting that migraine is not associated with atherosclerosis, a significant relationship was demonstrated in the present study. [11,16] Both of these studies used similar age profiles to the present study, notably the study by Besir et al, in which young female patients constituted majority of participants.…”

Section: Discussionmentioning

confidence: 68%

“…Hamed et al analyzed the association between migraine, vascular risk profile, endothelial injury, and CAIMT. [16] In their study, systolic and diastolic blood pressure, serum levels of glucose, insulin, endothelin-1, and CAIMT measurements were higher in migraine patients compared to healthy patients. Thus, they suggested that migraine is associated with specific vascular risk profile, and this strongly suggests that migraine could be a risk factor for atherosclerosis.…”

Section: Discussionmentioning

confidence: 86%

Evaluation of Subclinical Atherosclerosis in Migraine Patients by Ultrasound Radiofrequency-Data Technology, Preliminary Results

Tatar

Ergün

Celtikci

et al. 2016

Agri

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SummaryObjectives: Migraine is a headache disorder affecting approximately 12% of the population, predominantly female individuals. Migraine has been associated with vascular events such as stroke and cardiovascular disease. The close connection between these vascular disorders and atherosclerosis is well known. Carotid artery intima-media thickness (CAIMT) is a marker for detection of subclinical atherosclerosis. The present study is an analysis of the presence of subclinical atherosclerosis in migraine patients. Methods: CAIMT was evaluated in 25 female migraine patients and 27 female controls using innovative ultrasound (US) radiofrequency (RF) data technology. Mann-Whitney U test was used to compare measurements in patient and control groups. Results: There was a statistically significant difference between mean CAIMT of migraine patients and control group (p<0.005): mean CAIMT was 701±114 μm in migraine patients and 400±64 μm in control group. Conclusion: Migraine patients are more prone to atherosclerosis compared to healthy individuals. CAIMT measurement with sonography can be utilized in follow-up to detect subclinical atherosclerosis.Keywords: Carotid; intima-media thickness; migraine; ultrasound radiofrequency data technology. ÖzetAmaç: Migren, toplumun yaklaşık %12'sini ve ağırlıklı olarak da kadın bireyleri etkileyen bir baş ağrısı bozukluğudur. Migren, inme ve kalp-damar hastalığı gibi vasküler patolojiler ile ilişkilendirilmiştir. Bu vasküler bozukluklar ile ateroskleroz arasındaki yakın bağlantı iyi bilinmektedir. Karotis arter intima media kalınlığı, subklinik aterosklerozun saptanması için bir göstergedir. Biz bu çalışmada; migren hastalarında subklinik aterosklerozun varlığını incelemeyi amaçladık. Gereç ve Yöntem: Karotis arter intima media kalınlığı, 25 kadın migren hastasında ve 27 kadın kontrol grubunda yeni bir teknik olan ultrason radyofrekans-veri teknolojisi ile değerlendirildi. Hasta ve kontrol gruplarında fark varlığını analiz etmek için Mann-Whitney U testi kullanıldı. Bulgular: Migren hastaları ve kontrol grubu arasında ortalama karotis intima media kalınlığı açısından istatistiksel olarak anlamlı fark saptandı (p<0.005). Ortalama karotis intima media kalınlığı migren hastalarında 701±114 mikrometre iken kontrol grubunda 400±64 mikrometre ölçüldü. Sonuç: Migren hastaları, sağlıklı bireylere oranla ateroskleroza daha yatkındır. Sonografi ile karotis arter intima media kalınlığı ölçümü bu hastalarda subklinik aterosklerozun tanınması amacıyla takiplerde kullanılabilir.Anahtar sözcükler: Karotis; intima media kalınlık; migren; ultrason radyofrekans-veri analizi.

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Vascular Risk Factors, Endothelial Function, and Carotid Thickness in Patients with Migraine: Relationship to Atherosclerosis

Cited by 111 publications

References 40 publications

Migraine and risk of stroke in older adults

Migraine and risk of stroke in older adults

C-reactive protein and migraine. Facts or speculations?

Evaluation of Subclinical Atherosclerosis in Migraine Patients by Ultrasound Radiofrequency-Data Technology, Preliminary Results

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