Evaluation of Subclinical Atherosclerosis in Migraine Patients by Ultrasound Radiofrequency-Data Technology, Preliminary Results

Abstract

SummaryObjectives: Migraine is a headache disorder affecting approximately 12% of the population, predominantly female individuals. Migraine has been associated with vascular events such as stroke and cardiovascular disease. The close connection between these vascular disorders and atherosclerosis is well known. Carotid artery intima-media thickness (CAIMT) is a marker for detection of subclinical atherosclerosis. The present study is an analysis of the presence of subclinical atherosclerosis in migraine patients. Methods: CAIMT was evaluated in 25 female migraine patients and 27 female controls using innovative ultrasound (US) radiofrequency (RF) data technology. Mann-Whitney U test was used to compare measurements in patient and control groups. Results: There was a statistically significant difference between mean CAIMT of migraine patients and control group (p<0.005): mean CAIMT was 701±114 μm in migraine patients and 400±64 μm in control group. Conclusion: Migraine patients are more prone to atherosclerosis compared to healthy individuals. CAIMT measurement with sonography can be utilized in follow-up to detect subclinical atherosclerosis.Keywords: Carotid; intima-media thickness; migraine; ultrasound radiofrequency data technology. ÖzetAmaç: Migren, toplumun yaklaşık %12'sini ve ağırlıklı olarak da kadın bireyleri etkileyen bir baş ağrısı bozukluğudur. Migren, inme ve kalp-damar hastalığı gibi vasküler patolojiler ile ilişkilendirilmiştir. Bu vasküler bozukluklar ile ateroskleroz arasındaki yakın bağlantı iyi bilinmektedir. Karotis arter intima media kalınlığı, subklinik aterosklerozun saptanması için bir göstergedir. Biz bu çalışmada; migren hastalarında subklinik aterosklerozun varlığını incelemeyi amaçladık. Gereç ve Yöntem: Karotis arter intima media kalınlığı, 25 kadın migren hastasında ve 27 kadın kontrol grubunda yeni bir teknik olan ultrason radyofrekans-veri teknolojisi ile değerlendirildi. Hasta ve kontrol gruplarında fark varlığını analiz etmek için Mann-Whitney U testi kullanıldı. Bulgular: Migren hastaları ve kontrol grubu arasında ortalama karotis intima media kalınlığı açısından istatistiksel olarak anlamlı fark saptandı (p<0.005). Ortalama karotis intima media kalınlığı migren hastalarında 701±114 mikrometre iken kontrol grubunda 400±64 mikrometre ölçüldü. Sonuç: Migren hastaları, sağlıklı bireylere oranla ateroskleroza daha yatkındır. Sonografi ile karotis arter intima media kalınlığı ölçümü bu hastalarda subklinik aterosklerozun tanınması amacıyla takiplerde kullanılabilir.Anahtar sözcükler: Karotis; intima media kalınlık; migren; ultrason radyofrekans-veri analizi.

Ultrasonic assessment of carotid intima-media thickness in migraine: a meta-analysis

“…Seven studies were finally included in the meta-analysis (Table 1). 17–19,25–28 All seven papers were published between 2010 and 2016 and were carried out in five countries: Egypt, Turkey, Germany, Croatia, and Italy. All studies enrolled patients with both MA and MO, except for the trial by Liman et al.…”

“…Carotid artery stenosis is an important change in patients with ischemic stroke, 13,14 and carotid intima-media thickness (IMT) is often assessed to monitor the pathological condition of atherosclerosis in clinical practice. 15 Some studies have also assessed this index in patients with migraine 16,17 and showed that migraine patients had greater carotid IMT than controls. 17–20 IMT may thus be a possible marker for assessing the risk of migraine.…”

“…15 Some studies have also assessed this index in patients with migraine 16,17 and showed that migraine patients had greater carotid IMT than controls. 17–20 IMT may thus be a possible marker for assessing the risk of migraine. The current meta-analysis aimed to compare carotid IMT between patients with migraine and healthy individuals.…”

The value of carotid intima-media measurements during the periods of attack and remission of migraine disease and tension-type headache in differential diagnosis

“…In a study conducted by Tatar et al, carotid intima-media thickness was evaluated between 25 women with migraine and 27 healthy women with a mean age of 33 ± 9 years and In the migraine group, a statistically significant increase was found and the association of migraine patients with subclinical atherosclerosis was reported [10]. In a similar study by Hamed et al, between 44 migraine patients in remission, 19 tension-type headache patients and 35 control groups, the thickness of carotid intima-media were compared and CIMT measurements of migraine with and without aura were significantly higher than tension headache and control groups [20].…”

“…In a study conducted in paediatric migraine patients, carotid intima-media thickness measurements were shown to be higher in patients with migraine than in the control group [9]. In another study conducted with 25 adult female migraine patients, carotid intima-media thickness was higher compared to the control group and it was concluded that migraine patients were prone to subclinical atherosclerosis [10].…”