Vascular Regeneration by Stem/Progenitor Cells

Xie, Yao; Fan, Yi; Xu, Qingbo

doi:10.1161/atvbaha.116.307303

Cited by 25 publications

(16 citation statements)

References 85 publications

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“…109 Recently, several publications in ATVB and other journals have demonstrated the progress in research on the role of stem/progenitor cells in atherosclerosis and oxidative stress. 13,[110][111][112][113][114] As mentioned earlier, oxidative stress response is a key event in the development of atherosclerosis, in which stem/progenitor cells sense the signal of ROS and other related species. One of the primary roles of ROS is to promote stem cell differentiation into SMCs important for both of neointimal formation after angioplasty and plaque stability.…”

Section: Stem/progenitor Cellsmentioning

confidence: 94%

“…[4][5][6] This, in addition to the accumulation of cholesterol and smooth muscle cells (SMCs) in the intima, leads to the transformation of monocytes into foam cells, which consume dead cells and lipids. [7][8][9] The atherogenic process involves multiple cell types, that is, endothelial cells (ECs), 10 SMCs, 11 immune cells, 12 and stem/progenitor cells, 13 in which levels of both intracellular and extracellular reactive oxygen and nitrogen species play a fundamental role in vascular cell homoeostasis and eventually affects the development of atherosclerosis.…”

mentioning

confidence: 99%

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Reactive Oxygen Species Generation and Atherosclerosis

Nowak

Deng

Ruan

et al. 2017

ATVB

Self Cite

115

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Section: Stem/progenitor Cellsmentioning

confidence: 94%

mentioning

confidence: 99%

Reactive Oxygen Species Generation and Atherosclerosis

Nowak

Deng

Ruan

et al. 2017

ATVB

Self Cite

115

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“…SMCs and pericytes/fibroblasts are the mainly responsible cell types for the secretion of highly collagenous ECM, in tunica media and tunica adventitial respectively (Moosmang et al, 2003;Sartore et al, 2001). It has been demonstrated that vascular wall resident stem/progenitor cells are able to migrate, proliferate and differentiate into SMCs lineage (Majesky, Dong, Hoglund, Daum, & Mahoney, 2012;Tang et al, 2012;Torsney & Xu, 2011;Xie, Fan, & Xu, 2016). However, SMCs regeneration is still controversial.…”

Section: Strategies For Ecm and Smcs Regenerationmentioning

confidence: 99%

“…Thus the vascular wall resident stem/progenitor cells are essential for SMCs regeneration. It has been demonstrated that vascular wall resident stem/progenitor cells are able to migrate, proliferate and differentiate into SMCs lineage (Majesky, Dong, Hoglund, Daum, & Mahoney, 2012;Tang et al, 2012;Torsney & Xu, 2011;Xie, Fan, & Xu, 2016). Xu Qingbo's group identified a population of multipotent and lineage committed progenitor cells resident in the aorta adventitial of ApoE-deficient mice (Hu et al, 2004).…”

Section: Strategies For Ecm and Smcs Regenerationmentioning

confidence: 99%

Strategies in cell‐free tissue‐engineered vascular grafts

Yuan

Chen

Liu

et al. 2019

J Biomedical Materials Res

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Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality in the world, among which coronary artery diseases (CAD) are the most common type of CVD. Coronary artery bypass grafting (CABG) using autologous vein and artery grafts is the typical surgical intervention for CAD patients. However, for patients whose autologous grafts are not available, there are no appropriate substitutes for vascular grafts. Investigation of tissue-engineered vascular graft (TEVG) has persisted over decades with significant advancement, utilizing different types of biomaterials.In the past two decades, a great number of studies based on cell-seeding strategies were reported. However, limitations of cell-based strategies made clinical application difficult. With the understanding of stem cells and tissue remodeling process, strategies without cell-seeding emerged as potential methods to achieve in situ regeneration.A cell-free graft may recruit host cells and guide their participation in vascular remodeling. The grafts modified by bio-active molecules showed good results in promoting in situ regeneration and exhibited potential to make the vascular grafts off-the-shelf.In this review, the strategies for cell-free TEVG manufacturing were discussed, including the materials for fabricating TEVGs, the methods of functionalization to promote in situ regeneration, the challenges researchers faced in TEVG investigation, and finally the prospects in TEVG design.

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“…If its expression is inhibited, the tight junction of the endothelial cells will be destroyed, and the cells will be more prone to phenotypic changes. Early studies have shown that Notch signalling is activated in the atrioventricular ducts, inducing the guanosine cyclase isoform subunit Gucy1a3 and Gucy1b3 transcription while promoting endothelial cell secretion of integrin A, activation of cells within the eNOS, PI3K/AKT so that eNOS phosphorylation of NO, NO and the receptor Gucy1a3 and Gucy1b3 interaction, regulation of endothelial cell transformation, to promote the development of ventricular calculi [32]. In this process, the Notch signalling pathway and the TGF-b signalling pathway are synergistic.…”

Section: Notch Signalling Pathway Enhances As By Promoting Endotheliamentioning

confidence: 99%

Effects of Notch signalling pathway on the relationship between vascular endothelial dysfunction and endothelial stromal transformation in atherosclerosis

Mao

Jiang

2017

Artificial Cells, Nanomedicine, and Biotechnology

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At present, with the improvement of living standards and population aging, the incidence of cardiovascular and cerebrovascular disease is on the rise and has been a serious threat to human health. Statistics show that the current death caused by cardiovascular and cerebrovascular disease has become the first cause of death has been increasing year by year. Therefore, studies on coronary heart disease and atherosclerosis (AS) have become a hot topic in clinical and basic research. In this study, the question of the effect of Notch signalling pathway on the relationship between endothelial dysfunction and endothelial stromal transformation in AS was studied in depth. Based on our results, we drew conclusions as follows. First, the Notch signalling pathway was activated in the atherosclerotic model; secondly, the Notch signalling pathway was demonstrated to enhance AS by promoting vascular endothelial dysfunction; thirdly, it was demonstrated that the Notch signalling pathway was mediated by promoting endothelial and to enhance AS; finally, we confirmed the endothelial function through the Notch signalling pathway to affect the transformation of endothelial stroma to achieve synergistic AS effect. The results of this study have a good guiding significance for the important role of Notch signalling in AS and indicate the ability to influence endothelial function and endothelial stromal transformation by intervening Notch signalling pathway and can affect the relationship between them, and thus eventually achieve the treatment of AS.

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Vascular Regeneration by Stem/Progenitor Cells

Cited by 25 publications

References 85 publications

Reactive Oxygen Species Generation and Atherosclerosis

Reactive Oxygen Species Generation and Atherosclerosis

Strategies in cell‐free tissue‐engineered vascular grafts

Effects of Notch signalling pathway on the relationship between vascular endothelial dysfunction and endothelial stromal transformation in atherosclerosis

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