Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures

Silverman, William F.; Krum, Janette M.; Mani, Nina; Rosenstein, Jeffrey M.

doi:10.1016/s0306-4522(98)00540-5

Cited by 223 publications

(151 citation statements)

References 39 publications

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“…Vascular endothelial growth factor is mitogenic for astrocytes and promotes growth/ survival of neurons (Silverman et al, 1999). Our data have shown that atorvastatin promotes angiogenesis, neuronal plasticity as well as increases VEGF/VEGFR2 expression.…”

Section: Discussionsupporting

confidence: 49%

Atorvastatin Induction of VEGF and BDNF Promotes Brain Plasticity after Stroke in Mice

Chen¹,

Zhang²,

Jiang³

et al. 2005

J Cereb Blood Flow Metab

403

337

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Molecular mechanisms underlying the role of statins in the induction of brain plasticity and subsequent improvement of neurologic outcome after treatment of stroke have not been adequately investigated. Here, we use both in vivo and in vitro studies to investigate the potential roles of two prominent factors, vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF), in mediating brain plasticity after treatment of stroke with atorvastatin. Treatment of stroke in adult mice with atorvastatin daily for 14 days, starting at 24 hours after MCAO, shows significant improvement in functional recovery compared with control animals. Atorvastatin increases VEGF, VEGFR2 and BDNF expression in the ischemic border. Numbers of migrating neurons, developmental neurons and synaptophysin-positive cells as well as indices of angiogenesis were significantly increased in the atorvastatin treatment group, compared with controls. In addition, atorvastatin significantly increased brain subventricular zone (SVZ) explant cell migration in vitro. Anti-BDNF antibody significantly inhibited atorvastatin-induced SVZ explant cell migration, indicating a prominent role for BDNF in progenitor cell migration. Mouse brain endothelial cell culture expression of BDNF and VEGFR2 was significantly increased in atorvastatin-treated cells compared with control cells. Inhibition of VEGFR2 significantly decreased expression of BDNF in brain endothelial cells. These data indicate that atorvastatin promotes angiogenesis, brain plasticity and enhances functional recovery after stroke. In addition, VEGF, VEGFR2 and BDNF likely contribute to these restorative processes.

show abstract

Section: Discussionsupporting

confidence: 49%

Atorvastatin Induction of VEGF and BDNF Promotes Brain Plasticity after Stroke in Mice

Chen¹,

Zhang²,

Jiang³

et al. 2005

J Cereb Blood Flow Metab

403

337

View full text Add to dashboard Cite

show abstract

“…In the adult nervous system it mediates neurogenesis [26], long term potentiation (LTP) [25], neuronal survival [23], astrocyte migration [52] and proliferation [53,54].…”

Section: Introductionmentioning

confidence: 99%

VEGFR1 and VEGFR2 in Alzheimer’s Disease

Harris

Miners

Allen

et al. 2017

JAD

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“…VEGF promotes the extension of axons of various types of neurons in vitro (Silverman et al 1999;Sondell et al 1999Sondell et al , 2000. In vivo, VEGF has been recently implicated in axon guidance in the visual system (Erskine et al 2011).…”

Section: Vegf As a Guidance Cue For Growing Axonsmentioning

confidence: 99%

Molecular Parallels between Neural and Vascular Development

Eichmann

Thomas

2012

Cold Spring Harbor Perspectives in Medicine

110

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The human central nervous system (CNS) features a network of 400 miles of blood vessels that receives .20% of the body's cardiac output and uses most of its blood glucose. Many human diseases, including stroke, retinopathy, and cancer, are associated with the biology of CNS blood vessels. These vessels originate from extrinsic cell populations, including endothelial cells and pericytes that colonize the CNS and interact with glia and neurons to establish the blood -brain barrier and control cerebrovascular exchanges. Neurovascular interactions also play important roles in adult neurogenic niches, which harbor a unique population of neural stem cells that are intimately associated with blood vessels. We here review the cellular and molecular mechanisms required to establish the CNS vascular network, with a special focus on neurovascular interactions and the functions of vascular endothelial growth factors.

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Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures

Cited by 223 publications

References 39 publications

Atorvastatin Induction of VEGF and BDNF Promotes Brain Plasticity after Stroke in Mice

Atorvastatin Induction of VEGF and BDNF Promotes Brain Plasticity after Stroke in Mice

VEGFR1 and VEGFR2 in Alzheimer’s Disease

Molecular Parallels between Neural and Vascular Development

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