Molecular Parallels between Neural and Vascular Development

Eichmann, Anne; Thomas, Jean‐Léon

doi:10.1101/cshperspect.a006551

Cited by 109 publications

(55 citation statements)

References 99 publications

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“…Neurons and vessels share similar signaling pathways that mediate differentiation, maturity, and migration. They also have similar parallel branching structures [72] . Therefore, neurogenesis and angiogenesis may infl uence each other after cerebral ischemia.…”

Section: Ischemiamentioning

confidence: 92%

Axon guidance factor netrin-1 and its receptors regulate angiogenesis after cerebral ischemia

Ding

Liao

2014

Neurosci. Bull.

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Neurogenesis and angiogenesis play important roles in functional recovery after ischemic stroke. When cerebral ischemia occurs, axon regeneration can compensate for the loss of apoptotic neurons in the ischemic area. The formation of new blood vessels ameliorates the local decrease in blood supply, enhancing the supply of oxygen and nutrients to newly-formed neurons. New blood vessels also act as a scaffold for the migration of neuroblasts to the infarct area after ischemic stroke. In light of this, researchers have been actively searching for methods to treat cerebral infarction. Netrins were fi rst identifi ed as a family of proteins that mediate axon guidance and direct axon migration during embryogenesis. Later studies have revealed other functions of this protein family. In this review, we focus on netrin-1, which has been shown to be involved in axon migration and angiogenesis, which are required for recovery after cerebral ischemia. Thus, therapies targeting netrin-1 may be useful for the treatment of ischemic stroke.

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Section: Ischemiamentioning

confidence: 92%

Axon guidance factor netrin-1 and its receptors regulate angiogenesis after cerebral ischemia

Ding

Liao

2014

Neurosci. Bull.

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“…Furthermore, cerebral vasculature also crucially participates in brain neural network formation and brain function in both the developing brain and adult brain. It has been shown that the structural generation and functional activity between cerebral vasculature and neurons are tightly linked together (Carmeliet and Tessier-Lavigne, 2005; Eichmann and Thomas, 2013). …”

Section: The Intrinsic Capability Of Brain Self-repair In Stroke Recomentioning

confidence: 99%

Enhancing endogenous capacity to repair a stroke-damaged brain: An evolving field for stroke research

Zhao

Willing

2018

Progress in Neurobiology

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Stroke represents a severe medical condition that causes stroke survivors to suffer from long-term and even lifelong disability. Over the past several decades, a vast majority of stroke research targets neuroprotection in the acute phase, while little work has been done to enhance stroke recovery at the later stage. Through reviewing current understanding of brain plasticity, stroke pathology, and emerging preclinical and clinical restorative approaches, this review aims to provide new insights to advance the research field for stroke recovery. Lifelong brain plasticity offers the long-lasting possibility to repair a stroke-damaged brain. Stroke impairs the structural and functional integrity of entire brain networks; the restorative approaches containing multi-components have great potential to maximize stroke recovery by rebuilding and normalizing the stroke-disrupted entire brain networks and brain functioning. The restorative window for stroke recovery is much longer than previously thought. The optimal time for brain repair appears to be at later stage of stroke rather than the earlier stage. It is expected that these new insights will advance our understanding of stroke recovery and assist in developing the next generation of restorative approaches for enhancing brain repair after stroke.

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“…Embryonic vascular formation involves vasculogenesis (the growth of new vessels from angioblasts), angiogenesis (the sprouting of new blood vessels from pre-existing vessels via endothelial migration and extracellular matrix remodelling), and vessel maturation and stabilization (Eichmann and Thomas, 2013;Wacker and Gerhardt, 2011). The formation of specialized features, such as those in the blood-brain barrier, may also ensue.…”

Section: Lpa Signalling During Vascular Developmentmentioning

confidence: 99%

Lysophosphatidic acid signalling in development

et al. 2015

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Lysophosphatidic acid (LPA) is a bioactive phospholipid that is present in all tissues examined to date. LPA signals extracellularly via cognate G protein-coupled receptors to mediate cellular processes such as survival, proliferation, differentiation, migration, adhesion and morphology. These LPA-influenced processes impact many aspects of organismal development. In particular, LPA signalling has been shown to affect fertility and reproduction, formation of the nervous system, and development of the vasculature. Here and in the accompanying poster, we review the developmentally related features of LPA signalling.

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Molecular Parallels between Neural and Vascular Development

Cited by 109 publications

References 99 publications

Axon guidance factor netrin-1 and its receptors regulate angiogenesis after cerebral ischemia

Axon guidance factor netrin-1 and its receptors regulate angiogenesis after cerebral ischemia

Enhancing endogenous capacity to repair a stroke-damaged brain: An evolving field for stroke research

Lysophosphatidic acid signalling in development

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