Vascular Function in Older Adults with Depressive Disorder

Severity of Depression and Anxiety Symptoms is Associated with Increased Arterial Stiffness in Depressive Disorder Patients Undergoing Psychiatric Treatment

“…Previous studies have shown that presence of depression increases the risk of CVD and the existing of CVD also increases the risk of depression 28,29 . In a study, higher values of PWV and AIx were of border significance in elder depressive patients 30 , and statistically significant association between PWV with depressive disorder has been reported 13 which is in line with our findings. In addition, in a recently published welldesigned study, the authors have compared 449 cases with lifetime diagnoses of depressive and/ or anxiety disorder and 169 healthy controls for PWV and AIx 5 .…”

Arterial stiffness is associated with depression in middle-aged men — the Maastricht Study

“…Conflicting results have been reported on the association between aortic stiffness and both the presence of major depressive disorder (MDD) [8][9][10] and depressive symptoms, 11,12 which may be explained by suboptimal study designs and/ or assessment of arterial stiffness and depression. A significant association between aortic stiffness and depression was observed in the population-based Rotterdam Study 10 and the AGES-Reykjavik Study, 11 whereas no association was found with depressive symptoms in the Health ABC Study.…”

“…In addition, (borderline) significant associations between aortic stiffness and MDD were reported in 2 relatively small cross-sectional studies. 8,9 Both the statistical power and the generalizability of the results might have been hampered in these studies because they had a case-control design. Additionally, one study 9 used less accurate measures to assess aortic stiffness,…”

Depression, Vascular Conditions and Chronicity

“…Studies investigating the association between depression and arteriosclerosis have used a variety of indexes for vascular function (Lavoie et al 2010;Oulis et al 2010;Paranthaman et al 2010;Rajagopalan et al 2001;Rybakowski et al 2006;Sherwood et al 2005;Tiemeier et al 2003). Irrespective of these different outcome measures, all studies unanimously have shown depressed individuals to have impaired endothelial function or increased arterial stiffness.…”