Vascular Endothelial Growth Factors and Progression of Periodontal Diseases

Abstract

VEGF may be a factor in initiation and progression of gingivitis to periodontitis, possibly by promoting expansion of the vascular network coincident to progression of the inflammation.

Expression of angiogenesis-stimulating factors (VEGF, CD31, CD105) and angiogenetic index in gingivae of patients with chronic periodontitis

“…by measuring the HEV-type blood vessel number, the number of 'standard' blood vessels and/or their diameter, and the presence of inflammatory infiltrates, due to the presence of positive immunocytochemical reaction. The results of some authors have documented increased concentrations of VEGF in gingivitis, which manifested correlation with depth of periodontal pocket [14]. This was associated with increased numbers of blood vessels and higher VEGF/IL-6 ratio in gingivae of patients with 4-6 mm depth of periodontal pocket, compared to healthy gingival fragments [14].…”

“…It can also be regarded as a factor of initiation and progression of gingivitis to periodontitis, i.e. through expansion of the blood vessel network [14]. Studies point to a correlation between VEGF concentration in gingival fluid and clinical parameters in CP patients (gingival index, CAL, radiologically detected bone loss) [15].…”

A morphological study of the blood vessels associated with periodontal probing depth in human gingival tissue

“…Vascular endothelial growth factor (VEGF) is also a novel growth factor for vascular endothelium (Ferrara et al, 2003). However, the VEGF concentrations are high, and there is an increase in the gingiva associated with periodontal diseases; they are not correlated with sulcular depth (Johnson et al, 1999). Therefore, we measured the diameter (μm) of the blood vessels in human cadavers with hematoxylin and eosin staining (HE) staining, after CD-31 positive endothelial cells of blood vessels from gingival biopsies on a human body donation specimen were examined by an immunohistochemical method.…”

The Use of Growth Factors in Periodontitis Treatment

“…Исследования различных авторов связи экс-прессии VEGF и васкуляризации с учетом коли-чества и диаметра кровеносных сосудов говорят, что рост VEGF может быть в большей степени отнесен к процессу исцеления пародонтоза, чем разрушения костной ткани [4,7]. Эти иссле-дования показали, что средний уровень VEGF увеличивается после лечения и снижается через 3 мес.…”

“…Эту экспрессию VEGF могут индуцировать IL-1β и TNFα. С другой стороны, VEGF, вероятно, сам является этиологическим фактором гингивита и прогрессирования пародонтита, инициируя расширение сосудистой сети на участках актив-ного воспаления пародонта, что, в свою очередь, может быть вызвано увеличением концентрации IL-1β [4].…”