Vascular Endothelial Growth Factor (VEGF) and Bone Morphogenetic Protein-4 (BMP-4) in Endochondral Ossification from Grafted Periosteum

Ueno, Takaaki; Kagawa, Toshimasa; Kanou, Miwa; Fujii, Takashi; Fukunaga, Joji; Mizukawa, Nobuyoshi; Sugahara, Toshio; Yamamoto, Tetsuro

doi:10.1267/ahc.36.61

Cited by 5 publications

(6 citation statements)

References 17 publications

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“…Increased expression of type XI collagen was reported in the twy mouse, where our group postulated the R. Sato et al potential roles of types I and II collagens in the progression of ossifed PLL plaque in the twy mouse. 2 Although a number of authors have described origins, 9,12,17,19,26,31 perhaps only the studies of Hirakawa et al, 11 Yonemori et al, 33 Ueno et al, 30 and our own, 2,8 including the present study, were dedicated to illustrating the histological properties of the OPLL process.…”

Section: Discussionmentioning

confidence: 56%

“…SSIFICATION of the posterior longitudinal ligament 4,5,20,30 of the spine may eventually cause serious spinal cord compromise. Ossification of the paravertebral tissue, including the spinal ligaments, may be evident in diffuse idiopathic skeletal hyperostosis, but in contrast to this, OPLL develops in isolation, frequently exhibiting in-significant ossification in the paravertebral areas.…”

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confidence: 99%

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Ossification of the posterior longitudinal ligament of the cervical spine: histopathological findings around the calcification and ossification front

Sato

Uchida

Kobayashi

et al. 2007

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Object. The authors studied the histological and immunohistochemical features of ossified posterior longitudinal ligament (PLL) of the cervical spine, especially in the calcification and ossification front. Methods. Samples of en bloc ossified PLL plaque obtained in 31 patients were stained with H & E and immuno-histochemically prepared for collagens (types I and II), vascular endothelial growth factor (VEGF), transforming growth factor (TGF)–β, and bone morphogenetic protein (BMP)–2, and by terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling method for apoptosis. Results. Enchondral ossification was evident between the ligamentous enthesis and deep layer of the ligament, with irregularly disorganized arrangement of elastic fibers in association with advancement of the degenerative process. In the ossification front, many hypertrophic metaplastic chondrocytes were noted in the ossifying plaque immediately contiguous to the ligament fibers, together with a considerable degree of neovascularization. Both TGFβ and BMP-2 were highly expressed in metaplastic hypertrophic chondrocytes in the ossification front, and BMP-2 was also expressed in fibroblastic cells near the ossified PLL plaque. Expression of type I collagen was significant in the matrix of the ossified PLL lesion, whereas that of type II was marked in metaplastic chondrocytes in the ossification front. Apoptotic hypertrophic chondrocytes were observed mainly in the fibrocartilaginous area near the calcification front. Conclusions. The enchondral ossification process in the ossified PLL was closely associated with degenerative changes of elastic fibers and cartilaginous cartilage formation, together with the appearance of metaplastic hypertrophic cartilage cells and neovascularization. The authors also found that VEGF-positive metaplastic chondrocytes in the ossification front and different expression patterns of collagens probably play some role in the extension of the ossified PLL from the ossification front.

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Section: Discussionmentioning

confidence: 56%

mentioning

confidence: 99%

Ossification of the posterior longitudinal ligament of the cervical spine: histopathological findings around the calcification and ossification front

Sato

Uchida

Kobayashi

et al. 2007

SPI

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“…We first observed that these hypertrophic chondrocytes expressed VEGF in the cytoplasm in endochondral ossication induced by rhBMP-2. Ueno et al reported that chondrocytes expressed VEGF during heterotopic bone formation induced from grafted periosteum in the rabbit followed by vascular invasion in VEGF-positive areas, and showed that this was related to the induction of vascularization of cartilage in grafted periosteum (Ueno et al, 2003). The periosteal grafting resulted in the proliferation and differentiation of various cells during the process of endochondral ossification, as also occurs in bone formation induced by rhBMP-2.…”

Section: Discussionmentioning

confidence: 99%

Immunolocalization of vascular endothelial growth factor on intramuscular ectopic osteoinduction by bone morphogenetic protein-2

et al. 2006

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“…Ueno et al . reported that VEGF is related to the induction of vascularization and may work cooperatively with BMP‐4 in the process of endochondral ossification induced from autogenously grafted periosteum. Takehiro et al .…”

Section: Discussionmentioning

confidence: 99%

Differences in the developmental origins of the periosteum may influence bone healing

Ichikawa

Watahiki

Nampo

et al. 2014

J of Periodontal Research

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Vascular Endothelial Growth Factor (VEGF) and Bone Morphogenetic Protein-4 (BMP-4) in Endochondral Ossification from Grafted Periosteum

Cited by 5 publications

References 17 publications

Ossification of the posterior longitudinal ligament of the cervical spine: histopathological findings around the calcification and ossification front

Ossification of the posterior longitudinal ligament of the cervical spine: histopathological findings around the calcification and ossification front

Immunolocalization of vascular endothelial growth factor on intramuscular ectopic osteoinduction by bone morphogenetic protein-2

Differences in the developmental origins of the periosteum may influence bone healing

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