Differences in the developmental origins of the periosteum may influence bone healing

Ichikawa, Y.; Watahiki, Junichi; Nampo, Tomoki; Nose, Kana; Yamamoto, Gou; Irié, Tarou; Mishima, Kenji; Maki, Koutaro

doi:10.1111/jre.12229

Cited by 32 publications

(25 citation statements)

References 52 publications

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“…Despite the histological similar appearance of the mesoderm- and CNCC-derived bones, the CNCC-derived bones of the jaw for example differ biologically; they possess distinct gene expression signatures, higher alkaline phosphatase activity, higher proliferation and greater regenerative capabilities (Heuze et al, 2014; Hochgreb-Hagele et al, 2015; Ichikawa et al, 2015; Quarto et al, 2010). Identifying the role of local signaling pathways that help to properly develop these cartilage structures is critical to the understanding of the precise shape and size that bones acquire, a requisite for their function.…”

Section: Introductionmentioning

confidence: 99%

Distinct requirements of wls , wnt9a , wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification

Ling

Rochard

Liao

2017

Developmental Biology

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Formation of the mandible requires progressive morphologic change, proliferation, differentiation and organization of chondrocytes preceding osteogenesis. The Wnt signaling pathway is involved in regulating bone development and maintenance. Chondrocytes that are fated to become bone require Wnt to polarize and orientate appropriately to initiate the endochondral ossification program. Although the canonical Wnt signaling has been well studied in the context of bone development, the effects of non-canonical Wnt signaling in regulating the timing of cartilage maturation and subsequent bone formation in shaping ventral craniofacial structure is not fully understood.. Here we examined the role of the non-canonical Wnt signaling pathway (wls, gpc4, wnt5b and wnt9a) in regulating zebrafish Meckel’s cartilage maturation to the onset of osteogenic differentiation. We found that disruption of wls resulted in a significant loss of craniofacial bone, whereas lack of gpc4, wnt5b and wnt9a resulted in severely delayed endochondral ossification. This study demonstrates the importance of the non-canonical Wnt pathway in regulating coordinated ventral cartilage morphogenesis and ossification.

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Section: Introductionmentioning

confidence: 99%

Distinct requirements of wls , wnt9a , wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification

Ling

Rochard

Liao

2017

Developmental Biology

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“…To this end, Ichikawa et al 27 previously reported abundant bone marrow-like tissue in the regenerated tissue of animals receiving transplanted maxillary bone and periosteum. Osteopontin promotes early differentiation of osteoblasts, their adhesion to bone, and subsequent bone formation.…”

Section: Discussionmentioning

confidence: 96%

The Usefulness of Mandibular and Maxillary Bone Derived from Neural Crest as Bone Graft Substitutes

Taguchi

Watahiki

Nampo

et al. 2016

Showa Univ J Med Sci

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: Autografts, which are commonly used for alveolar bone regeneration, often utilize the ilium and jaw bones as alternative bone graft materials. Maxillary and mandibular bones are developmentally derived from neural crest-derived cells NCDCs , while the majority of trunk and limb bones are derived from mesoblast cells. Consequently, the host bone graft material might differ in developmental origin from the recipient bone. With such a potential mismatch in practical terms, it is unclear whether genuine jaw bone can be regenerated. We hypothesized that bones derived from NCDCs and mesoblast cells show different capacities for in vivo bone healing. To investigate this proposal, we undertook bone graft experiments using a murine model. We rst perforated a 2-mm diameter area in both the frontal and parietal bones, which are derived from NCDCs and mesoblast cells, respectively ; then we grafted various source materials into each bone defect. Mice were euthanized at 2 weeks after grafting, and histological analyses and immunohistochemistry were performed to evaluate differences in bone healing based on the various combinations of graft and recipient bones. The frontal bone was found to heal faster than the parietal bone. Parietal bone defects transplanted with maxillary and mandibular bone grafts exhibited closure, whereas iliac and femoral bone grafts did not result in full healing. Immunostaining for osteopontin also demonstrated good bone regeneration in the parietal bone defects using maxillary and mandibular bone graft materials. These results suggest that maxilla and mandible bones exhibit NCDC properties with an enhanced healing potential. We conclude that maxillary and mandibular bones are effective bone graft and graft bed materials.

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“…For example, mandibular bone exhibits a higher proliferation, alkaline phosphatase activity, and has a distinct gene expression profile than the mesodermal bone in the tibia (Reichert et al, 2013). These differences are also observed between neural crest-derived tissue in the flat bones of the skull and long mesodermal bones, with increased periosteal response in crest versus mesoderm-derived bone healing (Ichikawa et al, 2014) and distinct susceptibility to mutations in FGFR2 S252 displayed in cranial bone such as the severe phenotypes observed in the Apert syndrome (Heuze et al, 2014).…”

Section: Introductionmentioning

confidence: 86%

Znf385C mediates a novel p53-dependent transcriptional switch to control timing of facial bone formation

Hochgreb-Hägele

Koo

Bronner‐Fraser

2015

Developmental Biology

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Jaw formation involves an intricate series of molecular events, whereby a chondrogenic scaffold precedes osteogenesis. The mechanisms coupling timing of cartilage maturation to onset of bone differentiation are poorly understood, particularly for neural crest-derived bones of the head. Here we present a novel zebrafish gene/protein-trap Citrine-fusion line that reveals transient expression of the zinc-finger protein Znf385C in maturing chondrocytes of the jaw. Functional analysis shows that loss of Znf385C disrupts a distinct peak of p21(cip1/waf1) expression in the chondrocytes, as well as causes premature ossification of the zebrafish jaw. We find that Znf385C is expressed as two splice variants which act differentially to activate p21(cip1/waf1) and/or interact with p53 in subcellular compartments. Taken together, the results suggest that Znf385C acts as a developmental switch for p53 function that modulates cell cycle arrest of chondrocytes and regulates timing of jaw cartilage maturation and ossification.

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Differences in the developmental origins of the periosteum may influence bone healing

Cited by 32 publications

References 52 publications

Distinct requirements of wls , wnt9a , wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification

Distinct requirements of wls , wnt9a , wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification

The Usefulness of Mandibular and Maxillary Bone Derived from Neural Crest as Bone Graft Substitutes

Znf385C mediates a novel p53-dependent transcriptional switch to control timing of facial bone formation

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