Vascular Endothelial Growth Factor Polymorphism in Bladder Cancer: A Review

Siregar, Ginanda Putra

doi:10.3889/oamjms.2020.3280

Cited by 2 publications

(4 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, Chen et al (2020) related the two polymorphisms, −460 T/C and −2578 C/A, to higher VEGF expression in BC [ 6 ]. Similar to VEGF, increased VEGFR expression was also found in BC [ 10 ]. In our study, the evaluation of the correlation between VEGFR1/VEGFR2 expression levels and BC parameters showed a significantly high level of VEGFR2 expression in MIBC.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, our interest was focused on three SNPs in the promoter region of the VEGFA gene, −460 T/C, −2578 C/A, and −2549 I/D, widely reported to be associated with many cancer developments and progressions [ 10 , 16 ]. In our findings, a significant association between −460 T/C SNP and smoking was reported.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, there are growing number of studies addressing the association between VEGFA gene SNPs and various cancer types, including urogenital carcinomas [ 8 ] and lung cancer [ 9 ]. Several polymorphisms in the VEGFA gene, especially in its promoter region, such as −460C/T (rs833061); −2578C/A (rs699947); and −2549I/D (rs35569394) have been widely reported to contribute to tumor growth and progression and may alter the expression level of VEGFA in various malignancies [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Evaluation of Vascular Endothelial Growth Factor A (VEGFA) and VEGFR2 Receptor as Prognostic Biomarkers in Bladder Cancer

et al. 2023

View full text Add to dashboard Cite

Vascular endothelial growth factor (VEGF) and its receptors (VEGFR1 and VEGFR2) are the most important tissue factors involved in tumor growth and angiogenesis. The aim of this study was to evaluate the promoter mutational status of VEGFA and the expression levels of VEGFA, VEGFR1, and VEGFR2 in bladder cancer (BC) tissues and to correlate the results with the clinical–pathological parameters of BC patients. A total of 70 BC patients were recruited at the Urology Department of the Mohammed V Military Training Hospital in Rabat, Morocco. Sanger sequencing was performed to investigate the mutational status of VEGFA, and RT-QPCR was used to evaluate the expression levels of VEGFA, VEGFR1, and VEGFR2. Sequencing of the VEGFA gene promoter revealed the presence of −460T/C, −2578C/A, and −2549I/D polymorphisms, and statistical analyses showed a significant correlation between −460T/C SNP and smoking (p = 0.02). VEGFA and VEGFR2 expressions were significantly up-regulated in patients with NMIBC (p = 0.003) and MIBC (p = 0.03), respectively. Kaplan–Meier analyses showed that patients with high VEGFA expression had significantly longer disease-free survival (p = 0.014) and overall survival (p = 0.009). This study was very informative, showing the implication of VEGF alterations in BC, suggesting that VEGFA and VEGFR2 expressions could be promising biomarkers for the better management of BC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Evaluation of Vascular Endothelial Growth Factor A (VEGFA) and VEGFR2 Receptor as Prognostic Biomarkers in Bladder Cancer

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Setelah itu, terjadi pengurangan destabilisasi vaskular dan penurunan formasi pembuluh darah baru, menunjukkan adanya keseimbangan antara regresi pembuluh darah dan pertumbuhan vaskular. 28 Penelitian ini juga menunjukkan hubungan yang bermakna antara ekspresi VEGF dengan invasi limfovaskular pada karsinoma urotelial infiltratif kandung kemih dengan nilai p=0,004 (p<0,05). Hasil ini sejalan dengan penelitian Poyet, et al (2017) bahwa terdapat hubungan signifikan antara ekspresi VEGF dengan invasi limfovaskular (p<0,05).…”

Section: Diskusiunclassified

The Correlation of VEGF Expression with Grade of Differentiation and Lymphovascular Invasion in Bladder Infiltrating Urothelial Carcinoma

Utami¹,

Agus²,

Yenita³

et al. 2022

MPI

View full text Add to dashboard Cite

Background Urothelial carcinoma is the most common malignancy in the bladder with an incidence up to 95% and 70-85% of them are bladder infiltrating urothelial carcinoma. To improve the management of bladder urothelial carcinoma, prognostic factors are required. One such factor is angiogenesis, which affects growth, development and metastasis. Vascular endothelial growth factor (VEGF) is the main pro-angiogenic factor to control angiogenesis. Expression of VEGF is correlated with progression of bladder infiltrating urothelial carcinoma, such as grade and lymphovascular invasion. The aim of this study was to determine the correlation of VEGF expression with grade of differentiation and lymphovascular invasion in bladder infiltrating urothelial carcinoma. Methods This research was a retrospective observational cross sectional study with 48 cases of bladder infiltrating urothelial carcinoma in four Anatomical Pathology Laboratory in West Sumatera 2018 and 2019. Samples were reevaluated of HE slide for grade of differentiation and lymphovascular invasion. VEGF expressions in tumor cell s were analyzed using immunohistochemistry staining. Bivariate statistical analysis used Fisher's Exact test and value p<0.05 was considered significant. Results Bladder infiltrating urothelial carcinoma high grade had more positive VEGF expression (91.7%), while low grade had more negative VEGF expression (58.3%). Lymphovascular invasion positive was mostly found with positive VEGF expression (75%). Statistical analysis showed significant correlation between VEGF expression with grade of differentiation (p=0.001) and lymphovascular invasion (p=0.004). Conclusion The conclusion was VEGF expression had significant correlation with grade of differentiation and lymphovascular invasion of bladder infiltrating urothelial carcinoma.

show abstract

Vascular Endothelial Growth Factor Polymorphism in Bladder Cancer: A Review

Cited by 2 publications

References 46 publications

The Evaluation of Vascular Endothelial Growth Factor A (VEGFA) and VEGFR2 Receptor as Prognostic Biomarkers in Bladder Cancer

The Evaluation of Vascular Endothelial Growth Factor A (VEGFA) and VEGFR2 Receptor as Prognostic Biomarkers in Bladder Cancer

The Correlation of VEGF Expression with Grade of Differentiation and Lymphovascular Invasion in Bladder Infiltrating Urothelial Carcinoma

Contact Info

Product

Resources

About