Vascular Endothelial Growth Factor in Gingival Tissues and Crevicular Fluids of Diabetic and Healthy Periodontal Patients

Abstract

The results of this study showed that VEGF is increased in all periodontal tissues of both groups and in the healthy sites of diabetic patients. Additionally, GCF VEGF values increased in periodontal sites of all test groups.

Oral hygiene in children with epilepsy: Effect of interleukin-1β and VEGF levels in gingival crevicular fluid

“…But they found statistically significant differences between periodontally healthy and unhealthy sites of these two groups, which is similar to Booth et al 18 Guneri's study indicated that the oral situation is more important than systemic disease for GCF mediators, because the VEGF levels in GCF were not different between periodontally healthy sites of diabetic patients and the control group. 17 This result indicates that oral hygiene may be one of the factors increasing VEGF that is unrelated to epilepsy.…”

“…27,28 Guneri et al investigated the VEGF concentration in GFC in patients with periodontal diseases. 17 Some of these patients (group I) had diabetic diseases, while the others (group II) were healthy without any systemic diseases. The differences of VEGF levels were found statistically insignificant between the periodontally healthy sites of these two groups and the negative control group.…”

“…13,14 The increased concentration of VEGF in periodontitis may be one of the reasons for the increased vascularization and permeability, and it may be considered as a sign of severe periodontitis. 13,17,18 VEGF is detectable in periodontal tissues within endothelial cells, plasma cells and macrophages, in junctional, sulcular and gingival epithelium, and in GCF. 18 Moreover, VEGF expression may be induced by IL-6, IL-1 and PGE 2 .…”

Growth Factors and Connective Tissue Homeostasis in Periodontal Disease

“…In a previous study on biopsies obtained from patients with type 2 diabetes associated gingival overgrowth, we detected VEGF expression in keratinocytes from the basal and spinous layers and in many de novo capillaries (Pisoschi et al, 2009). Other authors reported increased VEGF expression in epithelial cells and endothelial cells in periodontitis-affected gingiva (Guneri et al, 2004;Keles et al, 2010;Lucarini et al, 2009). Giannobile et al (2003) suggested that VEGF could be an important growth factor for the onset of gingivitis and its progression to periodontitis.…”

Gingival Inflammation as a Sign of Diabetic Systemic Chronic Complications

“…DM and periodontal disease are common chronic diseases in adults 22,23 . The general opinion is that there is no effect of gender on elevated blood glucose in diabetic patients, as noticed in this study, whereas both sexes were uniformly represented 24 .…”