Growth Factors and Connective Tissue Homeostasis in Periodontal Disease

Pisoschi, Cătălina Gabriela; Stănciulescu, Camelia Elena; Banita, Monica

doi:10.5772/33669

Cited by 11 publications

(19 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As is known, PDGF, VEGF, and IGF-1 increase the proliferation of fibroblasts and angioblasts, the synthesis of extracellular matrix, and angiogenesis process. 25 More neutrophil granulocytes in A-PRF also affects macrophage differentiation, resulting in the regeneration of hard and soft tissues. 16 The results of PD and RAL reduction between the OFD+A-PRF and OFD+PRF groups on days 30-90 did not show any significant differences.…”

Section: Discussionmentioning

confidence: 99%

Effect of advanced platelet-rich fibrin applications on periodontal regeneration in infrabony pocket treatment

Suwondo¹,

Herawati

Sudibyo

2019

Majalah Kedokteran Gigi Indonesia

View full text Add to dashboard Cite

One of the regenerative periodontal treatments for infrabony pocket is open flap debridement (OFD) with the addition of growth factor derived from platelet concentrate. Advanced platelet-rich fibrin (A-PRF) is a further development of plateletrich fibrin (PRF) with a lower centrifugation speed (1,500 rpm, 14 minutes). The purpose of this study was to examine the differences in periodontal tissue regeneration after the application of A-PRF and PRF in the treatment of infrabony pockets evaluated from probing depth (PD), relative attachment loss (RAL), and alveolar bone height. The samples were taken from 20 infrabony pockets divided into 2 groups: 10 subjects were treated with OFD+A-PRF and OFD+PRF on the remaining subjects. Probing depth (PD) and relative attachment loss (RAL) measurement were performed on days 0, 30, and 90. Bone height measurements were performed using CBCT X-rays on days 0 and 90. The results showed that PD and RAL reduction in the group of OFD+A-PRF was significantly greater than that in the OFD+PRF group. Bone height reduction in both groups showed no difference. The conclusion obtained from this study is A-PRF application enhances periodontal tissue regeneration by generating greater probing depth and relative attachment loss reduction compared to PRF, as well as an increase in bone height similar to in the treatment of infrabony pockets.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of advanced platelet-rich fibrin applications on periodontal regeneration in infrabony pocket treatment

Suwondo¹,

Herawati

Sudibyo

2019

Majalah Kedokteran Gigi Indonesia

View full text Add to dashboard Cite

show abstract

“…A study tool is needed for study the progression of these disease and therapeutic strategies in reducing bone resorption and tumor metastasis, prevent future disability. 26 We successfully establish periodontitis rat model in this study.…”

Section: Discussionmentioning

confidence: 96%

VEGFA And IL17 Expression Reveals Their Potential Functional Crosstalk in Periodontitis Rats-A New Animal Model for Angiogenesis Study

Zhang¹,

Ge²,

Zheng³

et al. 2014

JMEN

View full text Add to dashboard Cite

“…Growth factors and cytokines play an important role in the regulation of the gingival extracellular matrix turnover. Tumour necrosis factor- α (TNF- α ) and interleukins induce the expression of MMPs while transforming growth factor- β (TGF- β ) downregulates their synthesis and secretion and promotes the production of their natural tissue inhibitors, TIMPs [11]. Gene and polymorphism identification could result in a new diagnostic for risk examination, early detection of disease, and individual treatment approach.…”

Section: Discussionmentioning

confidence: 99%

“…Five distinct isoforms of TGF- β have now been described, and three of these—TGF- β 1, TGF- β 2, and TGF- β 3—are found in all mammalian species [11, 13]. TGF- β 1 is expressed in epithelial, hematopoietic, and connective tissue cells.…”

Section: Discussionmentioning

confidence: 99%

“…It is predominantly produced by T regulatory (Treg) cells and macrophages and could also induce a wide range of essential functions. Because TGF- β 1 exhibits both proinflammatory and anti-inflammatory properties besides its ability to stimulate migration and synthesis of ECM molecules and to inhibit the breakdown of ECM, it has been intensively evaluated in relation to all types of gingival enlargement [11, 14]. …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Change of TGF-β1 Gene Expression and TGF-β1 Protein Level in Gingival Crevicular Fluid and Identification of Plaque Bacteria in a Patient with Recurrent Localized Gingival Enlargement before and after Gingivectomy

Astuti

Hatta

Oktawati

et al. 2018

Case Reports in Dentistry

View full text Add to dashboard Cite

This case report highlights the change of TGF-β1 gene expressions and TGF-β1 protein level in gingival crevicular fluid (GCF) and identification of plaque bacteria in a patient with recurrent localized gingival enlargement before and after gingivectomy treatment. A 26-year-old woman came to AG Dental Care Clinic, South Sulawesi, Indonesia, in October 2015 with a chief complaint that her gingiva often bled spontaneously and she felt pain on her gingiva and felt less comfortable and no self-confidence with her anterior and posterior gingival condition on the right maxilla region which is slightly larger than normal. She often felt that her gingiva could bleed spontaneously when she was talking or remains silent though. The patient is disturbed by the malodor she felt. At that moment, the patient sought for gingivectomy treatment. Three years afterward, the patient came back with the same complaint. Gingival crevicular fluid has been taken from the gingival sulcus before and after gingivectomy. Clinical and GCF follow-up examination was performed one week and three weeks after gingivectomy, and successful results on biological, functional, and aesthetic parameters were observed.

show abstract

Growth Factors and Connective Tissue Homeostasis in Periodontal Disease

Cited by 11 publications

References 88 publications

Effect of advanced platelet-rich fibrin applications on periodontal regeneration in infrabony pocket treatment

Effect of advanced platelet-rich fibrin applications on periodontal regeneration in infrabony pocket treatment

VEGFA And IL17 Expression Reveals Their Potential Functional Crosstalk in Periodontitis Rats-A New Animal Model for Angiogenesis Study

Change of TGF-β1 Gene Expression and TGF-β1 Protein Level in Gingival Crevicular Fluid and Identification of Plaque Bacteria in a Patient with Recurrent Localized Gingival Enlargement before and after Gingivectomy

Contact Info

Product

Resources

About