Vascular endothelial function and plasma homocysteine levels in Behcet's disease

Decreased Serum Paraoxonase 1 Activity and Increased Serum Homocysteine and Malondialdehyde Levels in Age-Related Macular Degeneration

“…Homocysteine has a mitogenic activity in vascular smooth muscle cells. This can lead to arterial wall thickening as well as intracellular release of calcium in these cells, and thus increase their proliferation and the mass of extracellular matrix (Ozdemir et al 2004). Another theory is that homocysteine causes oxidative injury to endothelial cells and enhances the peroxidation of low-density lipoproteins, which in turn promotes the atheromatous process.…”

Venous Thrombosis in Behcet’s Disease

“…A study reported that 5 µmol/l increase of Hcy was associated with a 60% and 27% increased risk of venous thrombosis in retrospective and prospective studies, respectively (Omar et al, 2007). The association between Hcy levels and endothelial dysfunction and its correlation to the degree of endothelial damage has been shown in patients with BD (Ozdemir et al, 2004). Hcy generates superoxide and hydrogen peroxide, both of which have been linked to endothelial damage .…”

“…Hcy was shown to promote TNF-α mediated induction of vascular cell adhesion molecule-1 (VCAM-1) in endothelial cells (Silverman et al, 2002). Some studies have shown hyperhomocysteinemia as a correctable risk factor for thrombosis in BD (Kartal Durmazlar et al, 2008aOmar et al, 2007;Ozdemir et al, 2004;Er et al, 2002;Sarican et al, 2007). In a recent work, thrombogenesis in BD is discussed through the concept of Virchow's triad of venous thrombosis (La Regina et al, 2010).…”

Endothelial Function and Behçet Disease

“…20 Mean plasma tHcy levels were elevated in patients with BD and correlated well with the degree of endothelial damage. It was concluded that hyperhomocysteinemia may be an independent risk factor for venous thrombosis.…”

“…5 The hsCRP reflects systemic inflammation and is related to ED. 16,[18][19][20][21][22][23][24] These findings as well as coagulation and fibrinolytic abnormalities may contribute to ED in BD. 25 Other factors have been implicated in the ED process in BD such as increased low-density lipoprotein (LDL) oxidation and production of antibodies against oxidized LDL (oxLDL).…”