Endothelial Function and Behçet Disease

Balta, Şevket; Balta, İlknur; Demırkol, Sait; Öztürk, Cengiz; Demır, Mustafa

doi:10.1177/0003319713513146

Cited by 19 publications

(14 citation statements)

References 33 publications

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“…[16] Inflammatory cells, mediators, and responses from vascular cells play a major role in the pathogenesis of various phases of atherosclerosis [17], including the early development of atheroma as well as atherosclerotic plaque instability. [1] Endothelial dysfunction is considered as the primary lesion in the progression of atherosclerosis.…”

Section: Cvd and Endocanmentioning

confidence: 99%

Endocan: A novel inflammatory indicator in cardiovascular disease?

et al. 2015

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Section: Cvd and Endocanmentioning

confidence: 99%

Endocan: A novel inflammatory indicator in cardiovascular disease?

et al. 2015

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“…2 Some markers including IL-6, IL-1b, TNF-a, thrombomodulin, E-selectin, VEGF, and total homocysteine (tHcy) had been considered as inflammatory indicators in BD. 6 In addition, the total white blood cell (WBC) count and its subtypes can be an indicator of systemic inflammation. 7 The neutrophil-lymphocyte (N/L) ratio can easily be calculated.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil–Lymphocyte Ratio and Carotid–Intima Media Thickness in Patients With Behçet Disease Without Cardiovascular Involvement

Öztürk

Balta

et al. 2014

Angiology

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Behçet disease (BD) is associated with endothelial dysfunction and chronic inflammation. The neutrophil-lymphocyte (N/L) ratio and carotid intima-media thickness (cIMT) are markers of inflammation and vascular risk, respectively. We assessed the relationship between cIMT values and N/L ratio in BD (65 patients and 62 control participants). There were statistically significant differences in N/L ratios and cIMT values between the patients with BD and control group (P < .001). There were moderate positive correlations between cIMT value, C-reactive protein, and N/L ratio in patients with BD. Receiver-operating characteristic curve analysis suggested that the optimum N/L ratio cutoff point for patients with BD was 1.29, with a sensitivity, specificity, negative predictive value, and positive predictive value of 97, 77, 96, and 75%, respectively (area under curve: 0.691, 95% confidence interval = 0.600-0.782, P < .001). The N/L ratio may be a useful index of BD activity.

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“…6 And the affected organs show neutrophil and lymphocyte infiltration. 7,8 In recent years, the neutrophil/lymphocyte ratio (NLR), mean platelet volume (MPV), and platelet/lymphocyte ratio (PLR) has been shown as potential markers of inflammation in vascular disorders. There are several studies assessing NLR, PLR and MPV in various diseases including BD, keratoconus, age related macular degeneration, nonarteritic ischemic optic neuropathy, psoriasis, familial mediterranean fever, cardiovascular diseases and malignancies.…”

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confidence: 99%