Vascular dysfunction in obesity: Beneficial effects of aerobic exercise training in animal models

Sponton, Amanda Christine da Silva; Sousa, Andressa Silva; Delbin, Maria Andréia

doi:10.1590/s1980-6574201700si0007

Cited by 2 publications

(3 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, our continuous or interval exercise was effective to improve endothelium-dependent relaxation, even though the exercise sessions were carried out 3 times a week. This result is in agreement with previous findings showing improvement in relaxation response after exercise training sessions performed 5 times a week 9,29,32 .…”

Section: Discussionsupporting

confidence: 93%

“…In our study, aortas from SD animals showed endothelium-dependent relaxation of about 60%. This response is lower than that found in aortic rings from rats not exposed to fructose intake 26 and is like that observed in femoral rings from animals fed with a high-fat diet 29 . On the other hand, our continuous or interval exercise was effective to improve endothelium-dependent relaxation, even though the exercise sessions were carried out 3 times a week.…”

Section: Discussioncontrasting

confidence: 47%

“…Several studies have demonstrated that the impairment of endothelium-dependent relaxation is a consequence of high-fat diet intake and obesity in both, human and animal models [27][28][29] . A multiplicity of mechanisms has been proposed to explain the impairment of endothelial function, which includes oxidative stress 30,31 , a decrease in antioxidant capacity, and high plasma triglycerides 2,26 .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose

Joaquim

Oharomari

Vale³

et al. 2022

Motriz: rev. educ. fis.

View full text Add to dashboard Cite

We investigated the effects of continuous or interval aerobic exercise training on vascular reactivity of female rats fed with fructose. Methods: Female Wistar rats (8-wk old) were divided into: sedentary (SD), continuous training (CTR), and interval training (ITR). Moderate intensity training protocols consisted of running 3 days/week for 7 weeks. CTR ran 40 min at 30%À 40% of the maximal speed (MS) and TRI consisted of 7 sets of 1 min at 70% of MS followed by 3 min at 35% of MS. Animals were fed with standard chow and fructose (10%) in drinking water. Concentration-response curves to acetylcholine and phenylephrine, and oxidative stress biomarkers, were determined in the aorta. Body weight gain, visceral fat, and plasma triglycerides and glucose were also evaluated. Results:Endothelium-dependent relaxation was significantly increased by both exercise regimens (CTR: Emax = 85 ± 6% and ITR: Emax = 84 ± 1%) compared to sedentary rats (SD: Emax = 62 ± 5%). The contractile maximal response was not different but phenylephrine potency was increased in CTR (pEC 50 : 8.41 ± 0.19) and reduced in ITR (pEC 50 : 7.06 ± 0.11) compared to SD (pEC 50 : 7.77 ± 0.08). In addition, the generation of superoxide was lower in trained groups as compared with sedentary (about −28% in CTR and −22% in ITR). TBARS and nitrate/nitrite levels were not modified. Compared to the SD group, ITR gained 39% less body weight and CTR has 29% less visceral fat. Glucose and triglycerides were not modified. Conclusion: CTR and ITR, carried out 3 days/week, were efficient to improve endothelium-dependent relaxation and reduce superoxide generation in the aorta from female rats fed with fructose.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose

Joaquim

Oharomari

Vale³

et al. 2022

Motriz: rev. educ. fis.

View full text Add to dashboard Cite

show abstract

Effects of Exercise Training on Vascular Inflammatory Markers in High-fat Diet-induced Obese Rats

Kim

2020

Asian J Kinesiol

View full text Add to dashboard Cite

OBJECTIVES The purpose of this study was to confirm the positive effects on the inflammatory expression and functional changes of blood vessels by aerobic exercise training and dietary control in high-fat diet induced obese rats.METHODS Forty 10-week-old male Wistar rats were treated with high-fat diet for 6 weeks, followed by 4 groups as sedentary + chow diet group (Chow), sedentary + high fat diet group (HFD), exercise + chow diet group (Chow-Ex), high fat diet + Exercise group (HFD-Ex) after obesity induction. After treadmill running exercise and dietary treatment were performed for 8 weeks, body composition, endurance performance and muscular endurance, blood glucose, CRP, NO, insulin, eNOS, iNOS, protein expression of IL-6 and TNF-α in aortic vascular tissues was analyzed.RESULTS High-fat diet intake leads to an increase in body weight and visceral fat, an increase in insulin resistance and an increase in inflammation factors. The blood NO level was significantly higher (p <0.05) in the HFD and Chow groups than in the non-exercise group. Blood insulin levels were significantly higher (p <0.05) in the HFD group without exercise than in all other groups. Blood eNOS activity was significantly higher (p <0.05) in the HFD and Chow groups than in the non-exercise group. The expression level of IL-6 protein in the vascular tissues was significantly higher (p <0.05) in the HFD group without exercise than the other groups. The expression level of TNF-α was significantly lower (p <0.05) in the HFD and Chow groups than in the non-exercise group.CONCLUSIONS The results of this study confirmed that exercise training through aerobic exercise and dietary control may help to reduce inflammatory expression and improve vascular endothelial function in high-fat diet induced obese rats.

show abstract

Vascular dysfunction in obesity: Beneficial effects of aerobic exercise training in animal models

Cited by 2 publications

References 48 publications

Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose

Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose

Effects of Exercise Training on Vascular Inflammatory Markers in High-fat Diet-induced Obese Rats

Contact Info

Product

Resources

About