Vascular Dysfunction and Reduced Circulating Endothelial Progenitor Cells in Young Healthy UK South Asian Men

Murphy, C.; Kanaganayagam, Gajen; Jiang, Benyu; Chowienczyk, Phil; Zbinden, Rainer; Saha, Mrinal; Rahman, Salman; Shah, Ajay M.; Marber, Michael; Kearney, Mark T.

doi:10.1161/01.atv.0000258788.11372.d0

Cited by 134 publications

(125 citation statements)

References 54 publications

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“…13,14 Decreases have also been shown in patients with peripheral endothelial dysfunction and more recently in patients with coronary endothelial dysfunction in the setting of established coronary artery disease. 15,16 However, the concept of reduced circulating EPCs in both early and overt vascular disease has been also challenged by controversy regarding the definition of EPCs 17,18 and recent work which has demonstrated increased EPC numbers in advanced coronary disease 19 . Recently conflicting evidence has also been presented in the setting of cardiac syndrome X as defined by the presence of chest pain, an abnormal functional test and normal coronary angiography, where reduced numbers of EPCs as colony forming units were observed in despite increased numbers of circulating EPCs detected by flow cytometry.…”

Section: Introductionmentioning

confidence: 99%

Circulating CD34+ cell subsets in patients with coronary endothelial dysfunction

et al. 2008

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Section: Introductionmentioning

confidence: 99%

Circulating CD34+ cell subsets in patients with coronary endothelial dysfunction

et al. 2008

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“…In South Asians, impairments in endothelial function have been reported. Chambers et al showed that endothelium-dependent dilatation (measured as brachial artery flow-mediated dilatation) was reduced in South Asians living in the UK compared with White Caucasians and this was confirmed by other studies (161,164). In yet another study, although no difference in vasodilatation was observed after reactive hyperemia or sublingual nitroglycerin administration between the two ethnic groups, the increase in vasodilatation during hyperinsulinemia compared with basal conditions was significantly lower in South Asians (24).…”

Section: Nitric Oxide Bioavailability: Endothelial and Hdl-cholesteromentioning

confidence: 76%

“…Several studies have demonstrated that South Asians have lower NO bioavailability compared with White Caucasians (160,161). NO is mainly produced by the endothelium as a consequence of an interaction with HDL-cholesterol (HDL-C) (162,163).…”

Section: Nitric Oxide Bioavailability: Endothelial and Hdl-cholesteromentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Pathogenesis of type 2 diabetes in South Asians

Bakker

Sleddering

Schoones

et al. 2013

European Journal of Endocrinology

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The risk of developing type 2 diabetes mellitus (T2DM) is exceptionally high among both native and migrant South Asians. T2DM occurs more often and at a younger age and lower BMI, and the risk of coronary artery and cerebrovascular disease, and renal complications is higher for South Asians compared with people of White Caucasian descent. The high prevalence of T2DM and its related complications in South Asians, which comprise one-fifth of the total world's population, poses a major health and socioeconomic burden. The underlying cause of this excess risk, however, is still not completely understood. Therefore, gaining insight into the pathogenesis of T2DM in South Asians is of great importance. The predominant mechanism, in this ethnicity seems to be insulin resistance (IR) rather than an impaired b-cell function. In this systematic review, we describe several possible mechanisms that may underlie or contribute to the increased IR observed in South Asians.

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“…Ethnicity is another non-modifiable risk factor for CVD. According to the British heart foundation, these different ethnic groups have their own culture and traditions that they are engaged in [23].…”

Section: Discussionmentioning

confidence: 99%

Common Modifiable and Non-Modifiable Risk Factors of Cardiovascular Disease (CVD) among Pacific Countries

Mohammadnezhad¹,

Mangum²,

May³

et al. 2016

WJCS

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Introduction: Modifiable and non-modifiable risk factors contribute to the significant rise of non-communicable diseases (NCDs), most notably cardiovascular disease (CVD), in the Pacific Island nations. The aim of this study is to review previously published articles to understand common modifiable and non-modifiable risk factors of CVD among Pacific countries. Methods: This systematic review is conducted using different databases including; Scopus, Medline, EMBASE, and psycINFO. This systematic review is based on the Cochrane review process. All articles published in the English language from 1 st January 2000 to 1 st September 2016, will be included in the study. After reviewing all of the articles' titles, abstracts, and full text, the final articles were reviewed and the relevant data was included in the data extraction sheet. A descriptive analysis was conducted to measure the common risk factors of CVD in Pacific countries. Results: Overall, 45 articles met the inclusion criteria of the study. The results showed that age was the most common non-modifiable risk factor while diabetes, high blood lipid, and high blood pressure were the most common modifiable risk factors of CVD. There were only three interventional studies which had all of the significant influences in reducing the risk factors of CVD when the results were compared with the control group. Conclusion: While it is not possible to change the non-modifiable risk factors for CVD, we encourage policy makers to use the results of this study to develop health promotion strategies to address the modifiable risk factors for CVD. Interventional strategies are highly recommended in the Pacific countries to tackle the modifiable risk factors for CVD.

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Vascular Dysfunction and Reduced Circulating Endothelial Progenitor Cells in Young Healthy UK South Asian Men

Abstract: Objectives-The objective of this study was to examine determinants of excess coronary artery disease risk in UK South Asians, more prevalent in this population than UK Caucasians, by examining differences in risk factors, vascular function, and endothelial progenitor cells (EPCs

Cited by 134 publications

References 54 publications

Circulating CD34+ cell subsets in patients with coronary endothelial dysfunction

Circulating CD34+ cell subsets in patients with coronary endothelial dysfunction

MECHANISMS IN ENDOCRINOLOGY: Pathogenesis of type 2 diabetes in South Asians

Common Modifiable and Non-Modifiable Risk Factors of Cardiovascular Disease (CVD) among Pacific Countries

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