2012
DOI: 10.1590/s1980-57642012dn06030014
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Abstract: Pemphigus vulgaris is a systemic auto-immune medical condition that mainly manifests with changes in skin and vasculopathy. This is a case report of a 69-year-old male with confirmed histopathologic diagnosis of Pemphigus vulgaris presenting ulterior Cognitive Impairment, mostly in executive function. The patient was treated using steroids, immunomodulatory therapy, fluoxetine and galantamine. Neuropsychological testing and magnetic resonance (MRI) were performed. This is the first report of correlational cogn… Show more

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Cited by 1 publication
(2 citation statements)
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“…These findings are concordant with the results of a previous cross-sectional retrospective study reviewing 6406 admissions with a diagnosis of pemphigus in the United States across 11 years, which disclosed a significant association between pemphigus and Parkinson disease and a nearsignificant association between pemphigus and epilepsy. 3 Case reports have shown the coexistence of pemphigus with MS, 4-6 dementia, 7 and epilepsy 17,18 in individual patients. Nevertheless, a recent retrospective cohort study from Singapore found no significant association between pemphigus and neurologic conditions.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…These findings are concordant with the results of a previous cross-sectional retrospective study reviewing 6406 admissions with a diagnosis of pemphigus in the United States across 11 years, which disclosed a significant association between pemphigus and Parkinson disease and a nearsignificant association between pemphigus and epilepsy. 3 Case reports have shown the coexistence of pemphigus with MS, 4-6 dementia, 7 and epilepsy 17,18 in individual patients. Nevertheless, a recent retrospective cohort study from Singapore found no significant association between pemphigus and neurologic conditions.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, there have been several case reports suggesting that pemphigus coexists with multiple sclerosis (MS) [4][5][6] and dementia. 7 Evidence has recently accumulated suggesting an association between bullous pemphigoid, another autoimmune blistering disease, and neurologic conditions. [8][9][10][11][12] Since both bullous pemphigoid and pemphigus share similar pathogenesis involving autoantibody-mediated damage to the epithelial basement membrane zone in bullous pemphigoid and to epithelial cell surface antigens in pemphigus, it is of interest to investigate whether a similar association with neurologic diseases exists among patients with pemphigus.…”
mentioning
confidence: 99%